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List of works by Robert Rottapel

3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells

scientific article

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

scientific article published on 18 July 2011

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

scientific article published on 08 October 2013

A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

scientific article published on 9 October 2003

Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation

scientific article

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis

scientific article

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

scientific article published on 7 November 2016

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

scientific article

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

scientific article published on 15 November 2007

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

scientific article published in January 2005

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

scientific article

CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.

scientific article

Cbl-mediated ubiquitinylation and negative regulation of Vav.

scientific article published on 24 July 2003

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity

scientific article

Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages

scientific article published on 23 February 2015

Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

scientific article

Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.

scientific article

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

scientific article

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

article

Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues.

scientific article published in June 1995

Flow cytometric analysis of cytokine receptor signal transduction

scientific article published in July 2003

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7

article

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

scientific article published on October 2016

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction

scientific article published on August 14, 1998

Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response

scientific article

Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells

scientific article published on July 2004

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.

scientific article published on 17 January 2007

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.

scientific article

Interaction with the Phosphotyrosine Binding Domain/Phosphotyrosine Interacting Domain of SHC Is Required for the Transforming Activity of the FLT4/VEGFR3 Receptor Tyrosine Kinase

scientific article published in Journal of Biological Chemistry

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer

scientific article published on March 2017

Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis

scientific article

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells

scientific journal article

Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice

scientific article published in March 2015

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

scientific article

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

scientific article published on 31 October 2017

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

scientific article

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

article published in 2012

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.

scientific article published on 11 September 2014

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

scientific article

Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.

scientific article

Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation

scientific article published on 10 August 2009

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

scientific article published on 01 April 2001

Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor.

scientific article published on November 1997

Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase

scientific article published on August 1996

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

scientific article published on 28 June 2012

Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

scientific article published on August 2008

Putting the brakes on arthritis: can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis?

scientific article

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

scientific article published on 13 March 2017

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

scientific article published on 14 December 2009

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

scientific article published on 31 October 2016

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

scientific article

Regulation of cytokine receptor signaling by SOCS1.

scientific article

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens

scientific article

Regulation of the immune system by SOCS family adaptor proteins

scientific article

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss

scientific article published in December 2014

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

scientific article

Signal transduction by several KIT juxtamembrane domain mutations

scientific article published in July 2003

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

scientific article

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

scientific article

Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes

scientific article published on 07 August 2003

Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal

scientific article (publication date: 22 June 2001)

Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes

scientific article published in September 2003

Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease

scientific article published on 12 August 2003

Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis

scientific article published in April 2006

Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

scientific article

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

scientific article

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

scientific article published on 15 March 2010

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer

scientific article

The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation

scientific article published on 18 July 2012

The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response

scientific article published on 5 February 2007

The MAGUK family protein CARD11 is essential for lymphocyte activation

scientific journal article

The Mouse W/c-kit Locus

scientific article published on 01 January 1990

The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis

scientific article

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

scientific article

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

scientific article published on June 1991

The adapter 3BP2: how it plugs into leukocyte signaling

scientific article published on January 2006

The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

scientific article published on March 1991

The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse

scientific article published on November 2004

The tumor suppressor activity of SOCS-1.

scientific article

Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1

scientific article published on 8 January 2016

Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.

scientific article published on 5 June 2017

VHL: a very hip ligase

scientific article

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor

scientific article published on March 1, 1990

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

scientific article published on 31 January 2014