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List of works by Craig B. Thompson

A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics

scientific article

A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heart

scientific article published in 2022

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas

scientific article

A two-way street: reciprocal regulation of metabolism and signalling.

scientific article

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

scientific article

ATP citrate lyase inhibition can suppress tumor cell growth

scientific article

ATP citrate lyase is an important component of cell growth and transformation

scientific article

ATP-citrate lyase links cellular metabolism to histone acetylation

scientific article (publication date: 22 May 2009)

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

scientific article published in Nature

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

scientific article published on August 2003

Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus

scientific article published in August 2009

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

scientific article published on 6 January 2003

Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.

scientific article published on May 2004

Akt stimulates aerobic glycolysis in cancer cells

scientific article (publication date: June 2004)

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival ⬇️

scientific article published on October 1, 2003

Akt-dependent transformation: there is more to growth than just surviving

scientific article

Alkylating DNA damage stimulates a regulated form of necrotic cell death

scientific article

Alpha4 is an essential regulator of PP2A phosphatase activity

scientific journal article

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases ⬇️

scientific article published on June 20, 2011

Analysis of a lung defect in autophagy-deficient mouse strains

scientific article

Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.

scholarly article

Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation

scientific article

Ars2 promotes proper replication-dependent histone mRNA 3' end formation.

scientific article

Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila

scientific article

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.

scientific article published on 10 January 2018

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion

scientific article

At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

scientific article published on 26 April 2013

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

scientific article published in March 2018

Autophagy and ammonia ⬇️

scientific article published on January 1, 2012

Autophagy in cellular metabolism and cancer

scientific article

Autophagy in metazoans: cell survival in the land of plenty

scientific article

Autophagy: basic principles and relevance to disease

scientific article

BLyS and B cell homeostasis

scientific article

Basis of CTLA-4 function in regulatory and conventional CD4+ T cells ⬇️

scientific article published on March 7, 2012

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

scientific journal article

Bax and Bak independently promote cytochrome C release from mitochondria

scientific journal article

Bax regulates primary necrosis through mitochondrial dynamics

scientific journal article

Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death ⬇️

scientific article published on January 1, 2002

Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection.

scientific article published on August 2003

Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

scientific article

Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism

scientific article published on 19 September 2002

Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

scientific article published in November 2004

Brick by brick: metabolism and tumor cell growth

scientific article

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995. 3: 87-98 ⬇️

scientific article published on October 1, 2010

CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo

scientific article published in February 2003

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

scientific article

Cancer Metabolism Drives a Stromal Regenerative Response

scientific article published on 14 February 2019

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine.

scientific article

Cancer's sweet tooth

scientific article published on 01 June 2006

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article published on June 2010

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

scientific article published on September 2013

Cancer. DNA damage, deamidation, and death

scientific article published in November 2002

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

scientific article

Caspase regulation of genotoxin-induced neural precursor cell death

scientific article published in November 2003

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? ⬇️

scientific article published on March 16, 2012

Cellular metabolic stress: considering how cells respond to nutrient excess.

scientific article published on October 2010

Central role of ULK1 in type I interferon signaling

scientific article published on 16 April 2015

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

scientific article

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.

scientific article published on 13 February 2017

Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways.

scientific article published on 27 June 2016

Critical role for PI3-kinase in regulating the use of proteins as an amino acid source

scientific article published on 25 September 2017

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

scientific article published on 4 June 2004

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

scientific article

DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation

scientific article published on 29 July 2013

Death by design: apoptosis, necrosis and autophagy

scientific article

Defective autophagy leads to cancer

scientific article published on December 2003

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

scientific article published on 3 September 2002

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells

scientific article (publication date: December 2003)

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

scientific article

Diurnal rhythms of autophagy: implications for cell biology and human disease

scientific article published on 17 April 2008

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

scientific article published on 13 April 2017

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

scientific article published on July 2010

Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant Glioblastomas ⬇️

scientific article published on 06 March 2013

Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.

scientific article published on 30 March 2009

Facile Synthesis [5-13C-4-2H2]-L-Glutamine for Hyperpolarized MRS Imaging of Cancer Cell Metabolism ⬇️

scientific article published on June 11, 2011

Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment

scientific article published on 11 November 2021

Fuel feeds function: energy metabolism and the T-cell response

scientific article

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

scientific article

Glutamine addiction: a new therapeutic target in cancer

scientific article

Glutamine independence is a selectable feature of pluripotent stem cells

scientific article published on 08 July 2019

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

scientific article published on February 2015

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

scientific journal article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

HG-07DETECTION OF K27M MUTANT PEDIATRIC GLIOBLASTOMAS BY IMMUNOHISTOCHEMISTRY.

scientific article published on 21 April 2015

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

scientific article published on August 2007

HISTOPATHOLOGIC EVALUATION OF H3K27ME3 IS A PROGNOSTIC BIOMARKER FOR PEDIATRIC GLIOBLASTOMAS.

scientific article published in July 2014

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

scientific journal article

Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas

scientific article published on April 2013

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

scientific article published on May 2016

Homeostatic control of lymphocyte survival: potential origins and implications

scientific article

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

scientific article

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

scientific article

Hypoxia Induces Production of L-2-Hydroxyglutarate.

scientific article published on 23 July 2015

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

scientific article published on 21 November 2011

Hypoxia-induced energy stress regulates mRNA translation and cell growth

scientific article

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

scientific article published on 13 May 2013

IDH mutation impairs histone demethylation and results in a block to cell differentiation

scientific article (publication date: 15 February 2012)

Immunoglobulin gene diversification by gene conversion

scientific article

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

scientific article published on 13 July 2020

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

scientific article

Induction of sarcomas by mutant IDH2

scientific article published on September 2013

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

scientific article

Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release

scientific article published in April 2003

In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors

scientific article published on 16 October 2017

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation

scientific article published in December 2006

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

scientific article published on 17 September 2018

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

scientific article published on 22 January 2018

Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

scientific article published on 06 April 2022

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

scientific article published on 6 March 2017

Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells

scientific article

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

scientific article (publication date: 14 December 2010)

Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses.

scientific article published on 17 December 2012

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death

scientific article published on 4 December 2006

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

scientific article published on November 2016

Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation

scientific article

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

scientific article published on 12 May 2013

Metabolic Modulation of Epigenetics in Gliomas ⬇️

scientific article published on March 1, 2013

Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

scientific article published on 15 January 2020

Metabolic Regulation of Epigenetics ⬇️

scientific article published on July 3, 2012

Metabolic origins of spatial organization in the tumor microenvironment.

scientific article published on 28 February 2017

Metabolic regulation of cell growth and proliferation

scientific article published on 01 July 2019

Metabolic regulation of chromatin modifications and gene expression

scientific article published on 14 May 2018

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

scientific article (publication date: 20 March 2012)

Mitochondrial respiratory control is lost during growth factor deprivation

scientific article

Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

scientific article

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.

scientific article published on 27 November 2017

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

scientific article published on 27 July 2016

Nutrient acquisition strategies of mammalian cells

scientific article published on June 2017

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

scientific article published on 23 November 2020

Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells

scientific article

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

scientific journal article

PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.

scientific article

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

scientific article published on September 2016

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

scientific article published on February 2006

PTEN is a protein tyrosine phosphatase for IRS1

scientific article (publication date: June 2014)

Pathways of apoptosis in lymphocyte development, homeostasis, and disease

scientific article

Persistent fetal ocular vasculature in mice deficient in bax and bak

scientific journal article

Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth

scientific article published on 9 October 2006

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

scientific article published on 21 February 2002

Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413

scientific article published on October 1, 2011

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

scientific article published on 10 February 2005

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.

scientific article published on 16 April 2018

Preparation and Characterization of l-[5-11C]-Glutamine for Metabolic Imaging of Tumors ⬇️

scientific article published on December 15, 2011

Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis

scientific article published on August 2003

Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress

scientific article published on 05 March 2020

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

scientific article

Quantitative flux analysis reveals folate-dependent NADPH production.

scientific article

Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila

scientific article

Ras-driven cancer cells can scavenge exogenous lipids to support their proliferation.

scientific article published in June 2012

Regulation of T lymphocyte metabolism

scientific article published on April 2004

Revving the engine: signal transduction fuels T cell activation

scientific article published in August 2007

Role of Mitochondria in Ferroptosis

scientific article published on 20 December 2018

Serine catabolism regulates mitochondrial redox control during hypoxia

scientific article

Signaling in control of cell growth and metabolism

scientific article published on July 2012

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

scientific article

SnapShot: cancer metabolism pathways

scientific article published on 01 March 2013

Somatic Diversification of the Chicken

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

scientific article

Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors.

scientific article published on 29 December 2010

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

scientific article

T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis

scientific article published on March 2005

TM-15GLUTAMINE BASED PET IMAGING FACILITATES ENHANCED METABOLIC DETECTION OF GLIOMAS IN VIVO.

scientific article

Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

scientific article

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

scientific article

The CD28 signaling pathway regulates glucose metabolism

scientific article

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer

scientific article published on 05 June 2018

The Emerging Hallmarks of Cancer Metabolism

scientific article

The HIV-1 Vpr and glucocorticoid receptor complex is a gain of function interaction that prevents the nuclear localization of PARP-1.

scientific article published on 21 December 2006

The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1

scientific article

The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis

scientific article

The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration

scientific article published on 10 August 2007

The Pim kinases control rapamycin-resistant T cell survival and activation

scientific article

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.

scientific article published on 2 July 2015

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

scientific article

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

scientific article published on 18 September 2005

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

scientific article

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

scientific article

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

scientific article

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

scientific article published on 21 December 2012

The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool.

scientific article published in December 2003

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

scientific article published on 09 August 2007

The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.

scientific article published on May 2012

The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells

scientific article published in August 2003

The role of cell death in sexually dimorphic muscle development: male-specific muscles are retained in female bax/bak knockout mice

scientific article published on September 2008

The roles of therapy-induced autophagy and necrosis in cancer treatment

scientific article published on December 2007

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

scientific journal article

Therapeutic targets in cancer cell metabolism and autophagy ⬇️

scientific article published on July 10, 2012

Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.

scientific article published on 24 June 2002

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

scientific article

Translation in amino acid-poor environments is limited by tRNA<sup>Gln</sup> charging

scientific article published on 08 December 2020

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

scientific article published on 10 October 2019

Tumor suppressors and cell metabolism: a recipe for cancer growth

scientific article published on March 2009

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

scientific article published on 6 June 2008

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

scientific article published on 13 September 2007

Understanding the Warburg effect: the metabolic requirements of cell proliferation

scientific article

Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis

scientific article published on 10 September 2020

c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.

scientific article published on 19 November 2003

α-Ketoglutarate links p53 to cell fate during tumour suppression

scientific article published on 18 September 2019

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