List of works - Samuli Eldfors

3Precision systems medicine in urological Tumors – Molecular profiling and functional testing

A6.02 Somatic mutations in clonally expanded CD8+T cells in patients with newly diagnosed rheumatoid arthritis

scholarly article by Tiina Kelkka et al published February 2016 in Annals of the Rheumatic Diseases

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

scientific article

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

scientific article published on 19 April 2018

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

scientific article

Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient-derived cancer cells

scientific article published on 04 November 2018

Comparison of solution-based exome capture methods for next generation sequencing

scientific article

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

scientific article

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

scientific article published on 30 April 2018

Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia

scientific article published on 19 December 2018

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.

scientific article published on 14 August 2017

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

scientific article published on 17 April 2013

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? - Somatic mutational profiles vs. ovarian and colorectal carcinomas

scientific article published on 07 April 2020

Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

scientific article published on 11 November 2016

Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study

scientific article published on 07 January 2019

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

scientific article published on 8 August 2016

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.

scientific article published on 3 October 2016

Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

scientific article

Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

scientific article published on 5 May 2017

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

scientific article published on 20 September 2013

Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

scientific article published on 09 July 2020

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

scientific article published on 31 October 2016

Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia

scientific article published on 01 February 2020

Novel TBL1XR1, EPHA7 and SLFN12 mutations in a Sezary syndrome patient discovered by whole exome sequencing

scientific article published in May 2014

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

scientific article published on 27 February 2014

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

scientific article published on 06 December 2013

Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.

scientific article published on 25 January 2016

Sequencing of Lynch syndrome tumors reveals the importance of epigenetic alterations

scientific article published on 14 November 2017

Somatic STAT3 mutations in large granular lymphocytic leukemia ⬇️

scientific article

Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease

scientific article published on 07 May 2020

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.

scientific article

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

scientific article

List of works by Samuli Eldfors

3Precision systems medicine in urological Tumors – Molecular profiling and functional testing

A6.02 Somatic mutations in clonally expanded CD8+T cells in patients with newly diagnosed rheumatoid arthritis

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient-derived cancer cells

Comparison of solution-based exome capture methods for next generation sequencing

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? - Somatic mutational profiles vs. ovarian and colorectal carcinomas

Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.

Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia

Novel TBL1XR1, EPHA7 and SLFN12 mutations in a Sezary syndrome patient discovered by whole exome sequencing

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.

Sequencing of Lynch syndrome tumors reveals the importance of epigenetic alterations

Somatic STAT3 mutations in large granular lymphocytic leukemia ⬇️

Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer