List of works - Simion Chiosea

A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinoma.

scientific article

Alternate diagnostic test interpretation in a retrospective convenience cohort and clinical application of MPTX

scientific article published on 25 November 2020

BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression.

scientific article

Best cases from the AFIP: ameloblastoma and dentigerous cyst associated with impacted mandibular third molar tooth

scientific article published on 01 September 2010

Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature

scientific article published on 21 August 2014

Carcinoma ex-Schneiderian papilloma (malignant transformation): a clinicopathologic and immunophenotypic study of 20 cases combined with a comprehensive review of the literature

scientific article

Clear Cell Carcinoma of Salivary Glands Is Frequently p16 Positive: A Pitfall in the Interpretation of Oropharyngeal Biopsies.

scientific article published on 26 October 2017

Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure.

scientific article published on 25 January 2017

Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation

scientific article

Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands.

scientific article published on 28 February 2012

Colorectal carcinomas, KRAS p.G13D mutant allele-specific imbalance, and anti-epidermal growth factor receptor therapy

scientific article

Colorectal poorly differentiated neuroendocrine carcinomas frequently exhibit BRAF mutations and are associated with poor overall survival

scientific article published on 17 November 2015

DICER1 and PRKRA in Colon Adenocarcinoma.

scientific article published on 28 April 2008

DOG1: a novel marker of salivary acinar and intercalated duct differentiation.

scientific article published on 30 March 2012

Does a specimen-based margin analysis of early tongue cancer better predict local control?

scientific article published on 16 June 2016

EGFR fluorescence in situ hybridization-positive lung adenocarcinoma: incidence of coexisting KRAS and BRAF mutations

scientific article published on 8 April 2010

Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control

scientific article

Early squamous cell carcinoma of the oral tongue with histologically benign lymph nodes: A model predicting local control and vetting of the eighth edition of the American Joint Committee on Cancer pathologic T stage

scientific article published on 07 June 2019

Early squamous cell carcinoma of the oral tongue: comparing margins obtained from the glossectomy specimen to margins from the tumor bed

scientific article published on 27 August 2013

Epithelial-Myoepithelial Carcinoma: Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases

scientific article published on 9 November 2017

Erlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer.

scientific article

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

scientific article

Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status.

scientific article published on 24 June 2013

First needle marrow biopsy to diagnose a systemic illness

scientific article published on 01 December 2012

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

scientific article published on 20 June 2012

Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

scientific article

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland

scientific article published on 01 February 2019

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

scientific article published on 01 April 2016

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

scientific article

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

scientific article

HMGA2 is a specific immunohistochemical marker for pleomorphic adenoma and carcinoma ex-pleomorphic adenoma

scientific article

HRAS mutations in epithelial-myoepithelial carcinoma

scientific article

Higher dosage of the epidermal growth factor receptor mutant allele in lung adenocarcinoma correlates with younger age, stage IV at presentation, and poorer survival.

scientific article

Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay.

scientific article

Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation.

scientific article published on 30 September 2015

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

scientific article

Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population

scientific article

Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes.

scientific article

Immunohistochemistry and HPV in situ hybridization in pathologic distinction between endocervical and endometrial adenocarcinoma: a comparative tissue microarray study of 76 tumors.

scientific article published in February 2013

Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology

scientific article

Improving margin revision: Characterization of tumor bed margins in early oral tongue cancer.

scientific article published on 24 October 2017

Incidence of human papillomavirus in oropharyngeal squamous cell carcinomas: now and 50 years ago.

scientific article

Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme.

scientific article

Intraoperative Margin Assessment in Early Oral Squamous Cell Carcinoma.

scientific article published on 10 December 2016

Intraoperative Margin Assessment in Head and Neck Cancer: A Case of Misuse and Abuse?

scientific article published on 02 March 2020

JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.

scientific article

KRAS mutant allele-specific imbalance in lung adenocarcinoma

scientific article (publication date: December 2011)

KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas

scientific article

KRAS mutational analysis and immunohistochemical studies can help distinguish pancreatic metastases from primary lung adenocarcinomas ⬇️

scientific article published on July 26, 2013

Large cell neuroendocrine carcinoma of the larynx: definition of an entity

scientific article

Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer

scientific article

Lynch syndrome-associated colorectal carcinoma: frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach

scientific article published on 10 September 2013

MAML2 Status in Mucoepidermoid Carcinoma Can No Longer Be Considered a Prognostic Marker

scientific article published on 01 August 2016

Mammary analogue secretory carcinoma mimicking salivary adenoma

scientific article published on 26 April 2013

Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma.

scientific article published on 3 June 2011

Management of the "violated neck" in the era of chemoradiation

scientific article published on 12 October 2011

Margin assessment in oral squamous cell carcinoma

scientific article published on 5 November 2013

Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges.

scientific article

Metastasis of breast carcinoma to the maxillary sinus

scientific article published on 02 April 2014

MicroRNA expression profiles in thyroid tumors.

scientific article published on January 2009

Molecular Profile of Locally Aggressive Well Differentiated Thyroid Cancers

scientific article published on 15 May 2020

Molecular changes in the multistage pathogenesis of head and neck cancer ⬇️

scientific article published on January 1, 2010

Molecular characterization of apocrine salivary duct carcinoma

scientific article

Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression.

scientific article published on February 2008

Mutant allele‐specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival ⬇️

scientific article published on March 22, 2012

Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.

scientific article

Occult Primary Head and Neck Squamous Cell Carcinoma: Utility of Discovering Primary Lesions.

scientific article published on 8 May 2014

On challenges of disproving inferiority of tumor bed margins

scientific article published on 15 August 2019

Oral squamous cell carcinoma with mandibular bone invasion: intraoperative evaluation of bone margins by routine frozen section.

scientific article

PIK3CA Mutations and PTEN Loss in Salivary Duct Carcinomas ⬇️

scientific article published on August 1, 2013

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.

scientific article

Pathology archive: evaluation of integrity, regulatory compliance, and construction of searchable database from print reports.

scientific article

Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study

scientific article published on 01 February 2019

Phase II randomized trial of radiation therapy, cetuximab, and pemetrexed with or without bevacizumab in patients with locally advanced head and neck cancer.

scientific article published on 13 May 2016

Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis

scientific article

Phosphaturic Mesenchymal Tumors: Clinicopathologic, Immunohistochemical and Molecular Analysis of 22 Cases Expanding their Morphologic and Immunophenotypic Spectrum.

scientific article published on 13 June 2017

Prevalence and phenotypic correlations of EIF1AX mutations in thyroid nodules

scientific article published on 24 February 2016

Primary RET-mutated lung neuroendocrine carcinoma in MEN2B: response to RET-targeted therapy

scientific article

Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein-Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines.

scientific article published on 2 November 2016

Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implications

scientific article

Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer

scientific article published on 23 March 2017

Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools

scientific article

Reappraising hyalinizing clear cell carcinoma: A population-based study with molecular confirmation.

scientific article published on 29 November 2016

Recurrent RET Gene Rearrangements in Intraductal Carcinomas of Salivary Gland

scientific article published on 25 October 2017

Retracted: Worst Pattern Of Invasion and occult cervical metastases for oral squamous carcinoma

retracted scientific article

SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity

scientific article

Salivary Duct Carcinoma: An Update on Morphologic Mimics and Diagnostic Use of Androgen Receptor Immunohistochemistry.

scientific article

Salivary duct carcinoma and the concept of early carcinoma ex pleomorphic adenoma

scientific article published on 30 October 2014

Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression.

scientific article

Solid Cell Nests, Papillary Thyroid Microcarcinoma, and HBME1

scientific article published on 01 July 2010

Solid Lymph Nodes as an Imaging Biomarker for Risk Stratification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma.

scientific article published on 27 April 2017

Squamous cell carcinoma metastatic to neck from an unknown primary: the potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus-positive oropharyngeal carcinoma prior to 1970.

scientific article

Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.

scientific article

THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer

scientific article published on 13 February 2017

TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation

scientific article

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Thyroid Carcinoma.

scientific article published on 28 September 2016

The Profile of Acinic Cell Carcinoma After Recognition of Mammary Analog Secretory Carcinoma ⬇️

scientific article published on March 1, 2012

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation

scientific article

The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases

scientific article published on 05 December 2012

The degree of intratumor mutational heterogeneity varies by primary tumor sub-site.

scientific article published on 28 March 2016

The mutational landscape of adenoid cystic carcinoma

scientific article published on 19 May 2013

The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma ⬇️

scientific article published on March 22, 2013

The spatial targeting and nuclear matrix binding domains of SRm160

scientific article

Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics

scientific article published on 12 August 2014

Thyroid paragangliomas are locally aggressive

scientific article published on 14 December 2011

Tribute: E. Leon Barnes, M.D.

scientific article published on 20 March 2012

Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma

scientific article

List of works by Simion Chiosea

A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinoma.

Alternate diagnostic test interpretation in a retrospective convenience cohort and clinical application of MPTX

BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression.

Best cases from the AFIP: ameloblastoma and dentigerous cyst associated with impacted mandibular third molar tooth

Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature

Carcinoma ex-Schneiderian papilloma (malignant transformation): a clinicopathologic and immunophenotypic study of 20 cases combined with a comprehensive review of the literature

Clear Cell Carcinoma of Salivary Glands Is Frequently p16 Positive: A Pitfall in the Interpretation of Oropharyngeal Biopsies.

Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure.

Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation

Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands.

Colorectal carcinomas, KRAS p.G13D mutant allele-specific imbalance, and anti-epidermal growth factor receptor therapy

Colorectal poorly differentiated neuroendocrine carcinomas frequently exhibit BRAF mutations and are associated with poor overall survival

DICER1 and PRKRA in Colon Adenocarcinoma.

DOG1: a novel marker of salivary acinar and intercalated duct differentiation.

Does a specimen-based margin analysis of early tongue cancer better predict local control?

EGFR fluorescence in situ hybridization-positive lung adenocarcinoma: incidence of coexisting KRAS and BRAF mutations

Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control

Early squamous cell carcinoma of the oral tongue with histologically benign lymph nodes: A model predicting local control and vetting of the eighth edition of the American Joint Committee on Cancer pathologic T stage

Early squamous cell carcinoma of the oral tongue: comparing margins obtained from the glossectomy specimen to margins from the tumor bed

Epithelial-Myoepithelial Carcinoma: Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases

Erlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer.

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status.

First needle marrow biopsy to diagnose a systemic illness

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

HMGA2 is a specific immunohistochemical marker for pleomorphic adenoma and carcinoma ex-pleomorphic adenoma

HRAS mutations in epithelial-myoepithelial carcinoma

Higher dosage of the epidermal growth factor receptor mutant allele in lung adenocarcinoma correlates with younger age, stage IV at presentation, and poorer survival.

Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay.

Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation.

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population

Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes.

Immunohistochemistry and HPV in situ hybridization in pathologic distinction between endocervical and endometrial adenocarcinoma: a comparative tissue microarray study of 76 tumors.

Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology

Improving margin revision: Characterization of tumor bed margins in early oral tongue cancer.

Incidence of human papillomavirus in oropharyngeal squamous cell carcinomas: now and 50 years ago.

Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme.

Intraoperative Margin Assessment in Early Oral Squamous Cell Carcinoma.

Intraoperative Margin Assessment in Head and Neck Cancer: A Case of Misuse and Abuse?

JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.

KRAS mutant allele-specific imbalance in lung adenocarcinoma

KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas

KRAS mutational analysis and immunohistochemical studies can help distinguish pancreatic metastases from primary lung adenocarcinomas ⬇️

Large cell neuroendocrine carcinoma of the larynx: definition of an entity

Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer

Lynch syndrome-associated colorectal carcinoma: frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach

MAML2 Status in Mucoepidermoid Carcinoma Can No Longer Be Considered a Prognostic Marker

Mammary analogue secretory carcinoma mimicking salivary adenoma

Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma.

Management of the "violated neck" in the era of chemoradiation

Margin assessment in oral squamous cell carcinoma

Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges.

Metastasis of breast carcinoma to the maxillary sinus

MicroRNA expression profiles in thyroid tumors.

Molecular Profile of Locally Aggressive Well Differentiated Thyroid Cancers

Molecular changes in the multistage pathogenesis of head and neck cancer ⬇️

Molecular characterization of apocrine salivary duct carcinoma

Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression.

Mutant allele‐specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival ⬇️

Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.

Occult Primary Head and Neck Squamous Cell Carcinoma: Utility of Discovering Primary Lesions.

On challenges of disproving inferiority of tumor bed margins

Oral squamous cell carcinoma with mandibular bone invasion: intraoperative evaluation of bone margins by routine frozen section.

PIK3CA Mutations and PTEN Loss in Salivary Duct Carcinomas ⬇️

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.

Pathology archive: evaluation of integrity, regulatory compliance, and construction of searchable database from print reports.

Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study

Phase II randomized trial of radiation therapy, cetuximab, and pemetrexed with or without bevacizumab in patients with locally advanced head and neck cancer.

Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis

Phosphaturic Mesenchymal Tumors: Clinicopathologic, Immunohistochemical and Molecular Analysis of 22 Cases Expanding their Morphologic and Immunophenotypic Spectrum.

Prevalence and phenotypic correlations of EIF1AX mutations in thyroid nodules

Primary RET-mutated lung neuroendocrine carcinoma in MEN2B: response to RET-targeted therapy

Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein-Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines.