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List of works by Christian Kellner

A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells.

scientific article published on 16 October 2015

A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells.

scientific article published in November 2008

A novel Fc-engineered human ICAM-1/CD54 antibody with potent anti-myeloma activity developed by cellular panning of phage display libraries

scientific article published on 5 September 2017

A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting.

scientific article published on January 2012

A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting

scientific article published on 16 July 2010

A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.

scientific article published on January 2011

Activity of everolimus (RAD001) in relapsed and/or refractory multiple myeloma: a phase I study.

scientific article

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

scientific article published on 3 December 2015

An Fc Double-Engineered CD20 Antibody with Enhanced Ability to Trigger Complement-Dependent Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity

scientific article published on 11 September 2017

An IgG3 switch variant of rituximab mediates enhanced complement-dependent cytotoxicity against tumour cells with low CD20 expression levels

scientific article published on 7 January 2013

Antibody-dependent cellular cytotoxicity in patients on chronic hemodialysis.

scientific article published on 23 October 2013

Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions ⬇️

scientific article published on July 9, 2013

CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells.

scientific article published on 14 July 2017

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

scientific article

Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.

scientific article

Effective elimination of acute myeloid leukemic cells by recombinant bispecific antibody derivatives directed against CD33 and CD16.

scientific article published in July 2010

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

scientific article published on 27 April 2017

Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96.

scientific article

Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30.

scientific article published on 05 June 2015

Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization.

scientific article published in January 2014

Fc engineering: design, expression, and functional characterization of antibody variants with improved effector function.

scientific article

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

scientific article published on 03 January 2014

HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity

scientific article published on 15 September 2015

Impact of Epidermal Growth Factor Receptor (EGFR) Cell Surface Expression Levels on Effector Mechanisms of EGFR Antibodies ⬇️

scientific article published on October 24, 2012

Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity

scientific article

Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy

scientific article published on 8 September 2017

Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy.

scientific article published on 17 December 2014

Monitoring and functional characterization of the lymphocytic compartment in pancreatic ductal adenocarcinoma patients

scientific article published on 11 July 2016

Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization.

scientific article published in November 2004

Novel bispecific antibodies increase γδ T-cell cytotoxicity against pancreatic cancer cells

scientific article published on 21 January 2014

Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells

scientific article

Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression

scientific article published in March 2012

Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.

scientific article

Selective induction of apoptosis in leukemic B-lymphoid cells by a CD19-specific TRAIL fusion protein

scientific article published on 31 July 2007

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation

scientific article published on 21 June 2010

The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patients ⬇️

scientific article published on January 1, 2013

The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells.

scientific article

The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA' enables screening of antibodies for immunotoxin development.

scientific article published on 18 February 2015

γδ T cell activation by bispecific antibodies

scientific article published on May 2015

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