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List of works by Ian E. Alexander

A genome-wide map of adeno-associated virus-mediated human gene targeting

scientific article published on 5 October 2014

A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells ⬇️

scientific article published on January 1, 2012

A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency.

scientific article

AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.

scientific article published on 9 October 2006

AAV-Mediated Gene Delivery to the Mouse Liver

scientific article published on 01 January 2019

AAV-encoded OTC activity persisting to adulthood following delivery to newborn spf(ash) mice is insufficient to prevent shRNA-induced hyperammonaemia.

scientific article published on 10 October 2013

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

scientific article published on 9 January 2018

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

scientific article published on 22 May 2015

Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?

scientific article

Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons.

scientific article

Adeno-associated virus serotypes for gene therapeutics.

scientific article published on 17 August 2015

Adeno-associated virus vectors preferentially transduce cells in S phase.

scientific article published on September 1994

Adeno-associated virus vectors show variable dependence on divalent cations for thermostability: implications for purification and handling.

scientific article

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells.

scientific article published in March 1995

Adeno-associated virus vectors: immunobiology and potential use for immune modulation.

scientific article published on August 2012

Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice

scientific article published on 02 July 2013

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort

scientific article published on 19 October 2018

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

scientific article

Australasian Gene Therapy Society kicks off.

scientific article

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

scientific article published on 25 September 2017

Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.

scientific article

C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression.

scientific article

CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection

scientific article published on April 2004

Cardiac Gene Therapy: Therapeutic Potential and Current Progress ⬇️

scientific article published on October 1, 2003

Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow

scientific article published on 01 September 2006

Clinical Trial of MGMT(P140K) gene therapy in the treatment of paediatric patients with brain tumours.

scientific article published on 31 January 2018

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

scientific article published on 01 November 2018

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions

scientific article published on 29 April 2015

Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.

scientific article published on 16 August 2012

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors.

scientific article published on December 1994

Delivering efficient liver-directed AAV-mediated gene therapy

scientific article published on 12 January 2017

Developing strategies for detection of gene doping.

scientific article published on January 2008

Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy.

scientific article published on 27 December 2004

Directed Evolution of Adeno-Associated Virus Vectors in Human Cardiomyocytes for Cardiac Gene Therapy

article

Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis

scientific article published on 15 February 2007

Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease.

scientific article

Expression and regulation of retinoic acid receptors in human breast cancer cells ⬇️

scientific article published on April 15, 1992

Fetal brain disruption sequence in sisters ⬇️

scientific article published on August 1, 1995

Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling.

scientific article

Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy.

scientific article

Gene therapy clinical trials worldwide to 2012 - an update.

scientific article published on February 2013

Gene therapy clinical trials worldwide to 2017: An update

scientific article published on 19 April 2018

Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.

scientific article

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.

scientific article

Gene therapy in sport

scientific article published on January 2006

Gene therapy in transplantation

scientific article published on 09 May 2009

Gene therapy: applications and progress towards the clinic.

scientific article

Gene therapy: progress in childhood disease.

scientific article published on 21 October 2011

Gene therapy: therapeutic applications and relevance to pathology

scientific article published on October 2011

Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells

scientific article published on 01 August 1988

Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus

scientific article

HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.

scientific article

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

scientific article published on 21 March 2017

Human PBMC-derived dendritic cells transduced with an adenovirus vectorinduce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro.

scientific article published in May 1999

Human fibroblasts transduced with CD80 or CD86 efficiently trans-costimulate CD4+ and CD8+ T lymphocytes in HLA-restricted reactions: implications for immune augmentation cancer therapy and autoimmunity.

scientific article

Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles

scientific article published on June 2011

Identification of a dynamic intracellular reservoir of CD86 protein in peripheral blood monocytes that is not associated with the Golgi complex ⬇️

scientific article published on June 1, 1998

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

scientific article published on 19 June 2017

Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.

scientific article

In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.

scientific article

Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery

scientific article

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells

scientific article published on 28 July 2014

Inverse relationship between estrogen receptor and epidermal growth factor receptor mRNA levels in human breast cancer cell lines

scientific article published on 01 January 1990

Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors

scientific article published in 2022

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

scientific article published on 10 December 2016

Liver-directed gene expression using recombinant AAV 2/8 vectors--a tolerogenic strategy for gene delivery?

scientific article published in June 2010

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.

scientific article

Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression

scientific article published on 30 March 2010

Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.

scientific article

Mitochondrial respiratory chain hepatopathies: role of liver transplantation. A case series of five patients.

scientific article

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system

scientific article published on 9 April 2015

Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection.

scientific article published in February 2009

PARTIAL PANCREATIC TRANSDIFFERENTIATION OF PRIMARY HUMAN HEPATOCYTES IN THE LIVERS OF A HUMANISED MOUSE MODEL.

scientific article published on 26 March 2018

Potential use of gene transfer in athletic performance enhancement.

scientific article published on 7 August 2007

Progestin inhibition of progesterone receptor gene expression in human breast cancer cells

scientific article published on 01 September 1989

Promoter interference mediated by the U3 region in early-generation HIV-1-derived lentivirus vectors can influence detection of transgene expression in a cell-type and species-specific manner.

scientific article published in August 2003

Restoring the natural tropism of AAV2 vectors for human liver

scientific article published on 01 September 2020

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

scientific article published on 25 December 2013

Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation

scientific article

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia

article by Caroline Michot et al published 6 April 2012 in Journal of Inherited Metabolic Disease

Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy.

scientific article published on 21 July 2016

The Molecular Bases of Phenylketonuria (PKU) in New South Wales, Australia: Mutation Profile and Correlation with Tetrahydrobiopterin (BH4) Responsiveness.

scientific article

The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors.

scientific article

The ethics of gene therapy: balancing the risks.

scientific article published on October 2010

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

scientific article published on 17 October 2013

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

scientific article published in August 1997

Transfer of Contaminants in Adeno-Associated Virus Vector Stocks Can Mimic Transduction and Lead to Artifactual Results ⬇️

scientific article published on November 1, 1997

Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus.

scientific article published on 30 July 2015

Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.

scientific article

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

scientific article published in August 2007

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