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List of works by Nicholas M. Kanaan

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures

scientific article

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

scientific article published on 01 December 2019

Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration

scientific article

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates ⬇️

scientific article published on May 18, 2011

Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats.

scientific article published on 21 July 2017

Aging and Parkinson's disease: Different sides of the same coin?

scientific article

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition

scientific article

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

scientific article published on 17 October 2017

Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.

scientific article published on 19 June 2012

Axonal transport defects in neurodegenerative diseases

scientific article published on October 2009

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons

scientific article published on 10 October 2016

Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

scientific article

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

scientific article

Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease.

scientific article published on 20 December 2005

Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies.

scientific article

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

scientific article published on 20 January 2016

Gene Therapy Models of Alzheimer's Disease and Other Dementias

scientific article published on January 2016

Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.

scientific article

Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization.

scientific article published on 17 March 2018

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

scientific article

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

scientific article

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

scientific article published on 04 June 2020

Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation

scientific article

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases ⬇️

scientific article published on July 6, 2011

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies.

scientific article published on 31 May 2016

Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation.

scientific article

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

scientific article

Pioglitazone prevents tau oligomerization.

scientific article published on 16 August 2016

Production of recombinant tau oligomers in vitro

scientific article

Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study

scientific article published on January 2016

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease

scientific article published on 08 March 2016

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport

scientific article published on 30 June 2016

Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures

scientific article

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

scientific article published on 21 June 2017

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain

scientific article

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

scientific article published on 20 November 2017

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.

scientific article published on 21 October 2016

Tau Kinetics in Neurons and the Human Central Nervous System

scientific article published on 01 March 2018

Tau Kinetics in Neurons and the Human Central Nervous System

scientific article published on 01 May 2018

Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease

scientific article published on 25 January 2018

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans

scientific article published on 7 March 2018

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes

scientific article published on 20 May 2015

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