List of works - Livio Brasili

(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenyl-propyl)-amine: a potent and selective 5-HT(1A) receptor agonist

scientific article

1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands

scientific article

1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors

scientific article published in March 2009

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors

scientific article published on 15 May 2010

1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists

scientific article published in April 2003

1‘-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4‘-piperidine] (Spipethiane), a Potent and Highly Selective σ1 Ligand ⬇️

scientific article published on May 7, 1998

2-D and 3-D modeling of imidazoline receptor ligands: insights into pharmacophore

scientific article published on 01 May 1997

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]-methyl] -1,4-benzoxathian: a new antagonist with high potency and selectivity toward alpha 1-adrenoreceptors.

scientific article published on December 1984

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors

scientific article published on 14 November 2011

A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues

Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation

Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.

scientific article

An Unexpected Central Hypertensive Effect of the New Imidazoline Compound Benazoline

scientific article published on 01 June 1999

Binding of Tracizolines to the Imidazoline Receptor: Role of Lipophilicity in Quantitative Structure-Activity Relationship Modelsa

scientific article published on 01 June 1999

Determination of muscarinic agonist potencies at M1 and M2 muscarinic receptors in a modified pithed rat preparation

scientific article published on 01 December 1990

Development, validation and application of an LC-MS/MS bioanalytical method for the quantification of GF449, a novel 5-HT1A agonist, in rat plasma and brain

scientific article published in January 2014

Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues

Discovery of a new series of 5-HT1A receptor agonists

scientific article published on 4 February 2010

Enigmatic receptors.

scientific article

Evaluation of stereo and chemical stability of chiral compounds

scientific article published on 20 September 2011

Fluoronorepinephrines: further pharmacological evaluation in vitro and in pithed rats.

scientific article

Further insights into the pharmacology of the human trace amine-associated receptors: discovery of novel ligands for TAAR1 by a virtual screening approach

scientific article published on 30 June 2014

Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian

scientific article published in September 1986

I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells.

scientific article

Identification of a Potent and Selective 5-HT1A Receptor Agonist with In Vitro and In Vivo Antinociceptive Activity

scientific article published on 02 December 2020

Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues

scientific article published in May 2003

Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity.

scientific article published in May 1997

Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modelling and docking studies.

scientific article published in April 2013

Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.

scientific article

Molecular Requirements of the Active Site of Cholinergic Receptors XV: Synthesis and Biological Activity of 2,3-Dehydrodeoxamuscarone and 2,3-Dehydrodeoxamuscarines ⬇️

scientific article published on May 1, 1981

N,N''-(dithio-2,1-ethanediyl)bis[N'-(pyrrol-2-ylmethyl)-1, 6,- hexanediamine] (pyrextramine), a new irreversible alpha 1-adrenoreceptor blocking agent of the tetramine disulfide class

scientific article published on 01 August 1984

Pharmacological characterization of muscarinic receptor subtypes in rabbit isolated tissue preparations.

scientific article published in October 1991

Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline

scientific article published on 01 November 1995

Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.

scientific article

Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity

scientific article published on 01 September 1988

Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity

scientific article published on 01 January 1989

Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists

scientific article published on 01 September 1985

Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity

scientific article published on 01 December 1988

Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on alpha 1-adrenoreceptor blocking activity.

scientific article published in January 1989

Structure-affinity relationship of cirazoline derivatives for idazoxan imidazoline-specific sites in the human cerebral cortex and the rabbit kidney

scientific article published on 01 July 1995

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors

scientific article

Structure–activity relationship at α-adrenergic receptors within a series of imidazoline analogues of cirazoline

scientific article published on 01 May 2000

Synthesis and Ca-antagonist activity of some benzhydryl derivatives.

scientific article

Synthesis and Structure-Activity Relationships of Triazaspirodecanone Derivatives as Nociceptin/Orphanin FQ Receptor Ligands

scientific article published on 20 January 2015

Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones.

scientific article published in June 1998

Synthesis and pharmacological evaluation of some analogues of the Ca-antagonist cinnarizine

scientific article published on 01 March 1988

Synthesis and structure-activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head.

scientific article

Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents ⬇️

scientific article published on September 1, 2012

Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(Acyloxymethyl)-1,3-dioxolanes

scientific article published in December 1996

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.

scientific article

Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors

scientific article published on 22 December 2011

The XIXth National Meeting on Medicinal Chemistry: Verona, Italy.

scientific article published in June 2009

Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum

scientific article published on 01 May 1986

Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane

scholarly article by Umberto Battisti et al published 21 January 2014 in Synthesis

List of works by Livio Brasili

(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenyl-propyl)-amine: a potent and selective 5-HT(1A) receptor agonist

1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands

1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors

1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists

1‘-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4‘-piperidine] (Spipethiane), a Potent and Highly Selective σ1 Ligand ⬇️

2-D and 3-D modeling of imidazoline receptor ligands: insights into pharmacophore

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]-methyl] -1,4-benzoxathian: a new antagonist with high potency and selectivity toward alpha 1-adrenoreceptors.

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors

A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues

Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation

Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.

An Unexpected Central Hypertensive Effect of the New Imidazoline Compound Benazoline

Binding of Tracizolines to the Imidazoline Receptor: Role of Lipophilicity in Quantitative Structure-Activity Relationship Modelsa

Determination of muscarinic agonist potencies at M1 and M2 muscarinic receptors in a modified pithed rat preparation

Development, validation and application of an LC-MS/MS bioanalytical method for the quantification of GF449, a novel 5-HT1A agonist, in rat plasma and brain

Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues

Discovery of a new series of 5-HT1A receptor agonists

Enigmatic receptors.

Evaluation of stereo and chemical stability of chiral compounds

Fluoronorepinephrines: further pharmacological evaluation in vitro and in pithed rats.

Further insights into the pharmacology of the human trace amine-associated receptors: discovery of novel ligands for TAAR1 by a virtual screening approach

Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian

I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells.

Identification of a Potent and Selective 5-HT<sub>1A</sub> Receptor Agonist with <i>In Vitro</i> and <i>In Vivo</i> Antinociceptive Activity

Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues

Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity.

Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modelling and docking studies.

Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.

Molecular Requirements of the Active Site of Cholinergic Receptors XV: Synthesis and Biological Activity of 2,3-Dehydrodeoxamuscarone and 2,3-Dehydrodeoxamuscarines ⬇️

N,N''-(dithio-2,1-ethanediyl)bis[N'-(pyrrol-2-ylmethyl)-1, 6,- hexanediamine] (pyrextramine), a new irreversible alpha 1-adrenoreceptor blocking agent of the tetramine disulfide class

Pharmacological characterization of muscarinic receptor subtypes in rabbit isolated tissue preparations.

Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline

Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.

Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity

Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity

Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists

Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity

Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on alpha 1-adrenoreceptor blocking activity.

Structure-affinity relationship of cirazoline derivatives for idazoxan imidazoline-specific sites in the human cerebral cortex and the rabbit kidney

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors

Structure–activity relationship at α-adrenergic receptors within a series of imidazoline analogues of cirazoline

Synthesis and Ca-antagonist activity of some benzhydryl derivatives.

Synthesis and Structure-Activity Relationships of Triazaspirodecanone Derivatives as Nociceptin/Orphanin FQ Receptor Ligands

Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones.

Synthesis and pharmacological evaluation of some analogues of the Ca-antagonist cinnarizine

Synthesis and structure-activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head.

Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents ⬇️

Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(Acyloxymethyl)-1,3-dioxolanes

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.

Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors

The XIXth National Meeting on Medicinal Chemistry: Verona, Italy.

Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum

Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane