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List of works by André Gustavo Tempone

A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division

scientific article published on 16 April 2019

Acetylenic fatty acids from Porcelia macrocarpa (Annonaceae) against trypomastigotes of Trypanosoma cruzi: Effect of octadec-9-ynoic acid in plasma membrane electric potential

scientific article published on 30 March 2018

Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole.

scientific article published on 29 December 2013

Activity of the antiarrhythmic drug amiodarone against () : an in vitro and in vivo approach

scientific article published on 25 October 2018

Alchornedine, a new anti-trypanosomal guanidine alkaloid from Alchornea glandulosa.

scientific article published on September 2014

An effective in vitro and in vivo antileishmanial activity and mechanism of action of 8-hydroxyquinoline against Leishmania species causing visceral and tegumentary leishmaniasis.

scientific article

Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes

scientific article

Anti-Trypanosoma cruzi activity of costic acid isolated from Nectandra barbellata (Lauraceae) is associated with alterations in plasma membrane electric and mitochondrial membrane potentials

scientific article published on 18 December 2019

Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.

scientific article published on 15 September 2010

Anti-leishmanial and anti-trypanosomal potential of polygodial isolated from stem barks of Drimys brasiliensis Miers (Winteraceae).

scientific article published on 18 January 2011

Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae).

scientific article published on 26 May 2011

Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula

scientific article

Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae).

scientific article published on 5 January 2017

Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum

scientific article published on 7 September 2015

Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)

scientific article published on 19 August 2019

Antileishmanial activity and ultrastructural alterations of Leishmania (L.) chagasi treated with the calcium channel blocker nimodipine.

scientific article published on 8 April 2009

Antileishmanial and antitrypanosomal activity of bufadienolides isolated from the toad Rhinella jimi parotoid macrogland secretion.

scientific article published on 15 July 2008

Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Siphonops annulatus

scientific article

Antimicrobial peptides isolated from Phyllomedusa nordestina (Amphibia) alter the permeability of plasma membrane of Leishmania and Trypanosoma cruzi

scientific article published on 8 October 2013

Antiparasitic activity and effect of casearins isolated from Casearia sylvestris on Leishmania and Trypanosoma cruzi plasma membrane.

scientific article

Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae).

scientific article published on 23 September 2008

Antiparasitic activity of natural and semi-synthetic tirucallane triterpenoids from Schinus terebinthifolius (Anacardiaceae): structure/activity relationships

scientific article published on 05 May 2014

Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods

scientific article published on 21 June 2018

Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil.

scientific article published on 5 January 2008

Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families.

scientific article published in May 2005

Antiprotozoal activity of extracts and isolated triterpenoids of 'carnauba' (Copernicia prunifera) wax from Brazil.

scientific article

Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei.

scientific article

Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae).

scientific article published on 7 May 2015

Antitrypanosomal Activity of Acetogenins Isolated from the Seeds of Porcelia macrocarpa Is Associated with Alterations in Both Plasma Membrane Electric Potential and Mitochondrial Membrane Potential

scientific article published on 02 May 2019

Antitrypanosomal activity and effect in plasma membrane permeability of (-)-bornyl p-coumarate isolated from Piper cernuum (Piperaceae)

scientific article published on 20 May 2019

Antitrypanosomal activity and evaluation of the mechanism of action of dehydrodieugenol isolated from Nectandra leucantha (Lauraceae) and its methylated derivative against Trypanosoma cruzi.

scientific article

Antitrypanosomal activity and evaluation of the mechanism of action of diterpenes from aerial parts of Baccharis retusa (Asteraceae).

scientific article published on 18 December 2017

Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera.

scientific article published on 18 March 2010

Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa)

scientific article published on 20 May 2019

Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil.

scientific article

Bioactivity-guided isolation of laevicarpin, an antitrypanosomal and anticryptococcal lactam from Piper laevicarpu (Piperaceae).

scientific article published on 12 April 2016

Brazilian flora extracts as source of novel antileishmanial and antifungal compounds.

scientific article published in August 2008

Butenolides from Nectandra oppositifolia (Lauraceae) displayed anti-Trypanosoma cruzi activity via deregulation of mitochondria

scientific article published on 09 October 2018

Combination therapy with nitazoxanide and amphotericin B, Glucantime®, miltefosine and sitamaquine against Leishmania (Leishmania) infantum intracellular amastigotes

scientific article published on 13 November 2013

Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity

scientific article published on 18 July 2020

Current approaches to discover marine antileishmanial natural products.

scientific article published on 17 January 2011

Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

scientific article

Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi

scientific article published on 02 May 2019

Dibenzylbutane neolignans from Saururus cernuus L. (Saururaceae) displayed anti-Trypanosoma cruzi activity via alterations in the mitochondrial membrane potential

scientific article published on 02 July 2019

Drug repurposing for Molecular basis of the leishmanicidal activity of the antidepressant sertraline

scientific article published in 2018

Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi.

scientific article published on 20 January 2012

Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi.

scientific article published in September 2017

Efficacy of sertraline against : an in vitro and in silico study

scientific article published on 30 October 2018

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria.

scientific article

Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives

scientific article published on 18 May 2019

Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar

scientific article published in 2022

Furazolidone is a selective in vitro candidate against Leishmania (L.) chagasi: an ultrastructural study.

scientific article published on 30 March 2010

Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.

scientific article published on 16 January 2016

Histamine H1-receptor antagonists against Leishmania (L.) infantum: an in vitro and in vivo evaluation using phosphatidylserine-liposomes

scientific article published on 4 June 2014

Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha

scientific article published on 2 April 2015

Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A

scientific article published on 25 March 2020

Insulin-like growth factor-I induces arginase activity in Leishmania amazonensis amastigote-infected macrophages through a cytokine-independent mechanism

scientific article

Investigation into in vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs

scientific article published in December 2011

Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum.

scientific article published on 28 January 2016

Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones.

scientific article published on 25 April 2017

Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).

scientific article published on 18 February 2010

Isolation of antileishmanial sterol from the fruits of Cassia fistula using bioguided fractionation.

scientific article published on July 2007

Kaempferol-3-O-α-(3,4-di-E-p-coumaroyl)-rhamnopyranoside from Nectandra oppositifolia releases Ca2+ from intracellular pools of Trypanosoma cruzi affecting the bioenergetics system

scientific article published on 16 September 2021

Leishmanicidal activity of an alkenylphenol from Piper malacophyllum is related to plasma membrane disruption.

scientific article published on 5 September 2012

Lethal action of the nitrothiazolyl-salicylamide derivative nitazoxanide via induction of oxidative stress in Leishmania (L.) infantum.

scientific article published on 23 September 2013

Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria

scientific article published in 2021

Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response.

scientific article

Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction.

scientific article

Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses

scientific article

Nanoliposomal Buparvaquone Immunomodulates Leishmania infantum-Infected Macrophages and Is Highly Effective in a Murine Model.

scientific article published on 6 February 2017

Natural products to anti-trypanosomal drugs: an overview of new drug prototypes for American Trypanosomiasis.

scientific article published on July 2007

Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages.

scientific article published on 29 August 2017

Neolignans isolated from twigs of Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity

scientific article published on 27 September 2018

New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum.

scientific article published on 29 March 2017

Pharmacokinetic of meglumine antimoniate encapsulated in phosphatidylserine-liposomes in mice model: A candidate formulation for visceral leishmaniasis

scientific article published on 07 May 2018

Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania (L.) infantum: biological activity and structure-activity relationships

scientific article

Rearranged Terpenoids from the Marine Sponge Darwinella cf. oxeata and Its Predator, the Nudibranch Felimida grahami.

scientific article published on 13 February 2017

Repurposing topical triclosan for cutaneous leishmaniasis: Preclinical efficacy in a murine Leishmania (L.) amazonensis model

scientific article published on 06 August 2020

Sertraline Delivered in Phosphatidylserine Liposomes Is Effective in an Experimental Model of Visceral Leishmaniasis

scientific article published on 29 October 2019

Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction

scientific article (publication date: 2013)

Synthesis and Structure-Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi

scientific article published on 13 October 2020

Synthesis and antileishmanial activities of novel 3-substituted quinolines.

scientific article

Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasis.

scientific article

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