List of works - Maik Hüttemann

(-)-Epicatechin Attenuates Degradation of Mouse Oxidative Muscle Following Hindlimb Suspension.

scientific article published in January 2016

(-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice

scientific article published on 13 March 2015

(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity

scientific article published on June 2013

(-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining

scientific article published on 16 December 2011

A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction

scientific article published on 5 November 2007

A suggested role for mitochondria in Noonan syndrome.

scientific article published on 14 October 2009

A third isoform of cytochrome c oxidase subunit VIII is present in mammals

scientific article published in July 2003

Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration

scientific article published on 29 November 2016

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

scientific article published on 21 January 2020

Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates

scientific article

Aerobic exercise preconception and during pregnancy enhances oxidative capacity in the hindlimb muscles of mice offspring

scientific article published on 3 January 2018

Antisense techniques provide robust decrease in GnRH receptor expression with minimal cytotoxicity in GT1-7 cells

scientific article published on 23 August 2018

Biochemical defects and genetic abnormalities in cytochrome c oxidase of patients with Leigh syndrome.

scientific article published on January 1998

Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation

scientific article

COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy

scientific article published on 23 August 2016

Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae

scientific article

Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function

scientific article published on 05 February 2019

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

scientific article published on 09 November 2019

Clinical Benefits of Remote Ischemic Preconditioning

scientific article published on 01 February 2014

Coadaptive evolution in cytochrome c oxidase: 9 of 13 subunits show accelerated rates of nonsynonymous substitution in anthropoid primates

scientific article published on 01 December 2004

Corrigendum to "Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function" [Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1864/5(2019) 654-661]

scientific article published on 04 May 2019

Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

scientific article published on 24 August 2020

Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines

scientific article published on 11 August 2015

Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment

scientific article

Cytochrome C oxidase and the regulation of oxidative phosphorylation.

scientific article

Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?

scientific article

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

scientific article

Cytochrome c oxidase-modulatory near-infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury

scientific article published on 09 November 2020

Cytochrome c oxidase: evolution of control via nuclear subunit addition

scientific article published on 23 July 2011

Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation

scientific article published on 6 August 2012

Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome

scientific article published on 8 December 2013

Different proteolipid protein mutants exhibit unique metabolic defects

scientific article

Discovering the phosphoproteome of the hydrophobic cytochrome c oxidase membrane protein complex.

scientific article published in January 2012

Diverse system stresses: common mechanisms of chromosome fragmentation.

scientific article published on 30 June 2011

EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming

scientific article published on 06 November 2019

Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis

scientific article

Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation

scientific article (publication date: 2014)

Epidermal growth factor receptor translocation to the mitochondria: regulation and effect

scientific article

Evolution of the couple cytochrome c and cytochrome c oxidase in primates

scientific article

Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model

scientific article

HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer

scientific article published on 16 May 2017

Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency

scientific article

Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats

scientific article

Inhibiting Mitochondrial Cytochrome <i>c</i> Oxidase Downregulates Gene Transcription After Traumatic Brain Injury in <i>Drosophila</i>

scientific article published on 15 March 2021

Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

scientific article

Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury

scientific article published on 22 February 2018

Insertion of proteolipid protein into mitochondria but not DM20 regulates metabolism of cells

Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphate

scientific article published on 31 December 2013

Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene

scientific article

Isolation of regulatory-competent, phosphorylated cytochrome C oxidase.

scientific article published in January 2009

Letter by Hüttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction"

scientific article published on 26 September 2019

Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells

scientific article published on 16 December 2016

Loss of tafazzin results in decreased myoblast differentiation in C2C12 cells: A myoblast model of Barth syndrome and cardiolipin deficiency

scientific article published on 22 April 2018

Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function

scientific article

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism

scientific article published on 12 October 2014

MNRR1, a Biorganellar Regulator of Mitochondria.

scientific article

Mammalian liver cytochrome c is tyrosine-48 phosphorylated in vivo, inhibiting mitochondrial respiration

scientific article published on 22 April 2008

Mammalian subunit IV isoforms of cytochrome c oxidase

scientific article

Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity

scientific article

MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes

scientific article published on 11 July 2017

Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy.

scientific article published on 20 November 2011

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

scientific article published on 15 June 2017

Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans

scientific article

Mitochondrial Structure, Function, and Dynamics: The Common Thread across Organs, Disease, and Aging.

scientific article published on 8 February 2018

Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy.

scientific article published on September 2009

Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase

scientific article

Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

scientific article (publication date: 2015)

Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation

scientific article

Multiple phosphorylations of cytochrome c oxidase and their functions

scientific article published on April 2012

Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation

scientific article published on 24 February 2013

New Prospects for an Old Enzyme: Mammalian CytochromecIs Tyrosine-Phosphorylated in Vivo†

scientific article published on 01 August 2006

Non-invasive treatment with near-infrared light: A novel mechanisms-based strategy that evokes sustained reduction in brain injury after stroke

scientific article published on 21 May 2019

Norethindrone is superior to combined oral contraceptive pills in short-term delay of menses and onset of breakthrough bleeding: a randomized trial

scientific article published on 28 May 2019

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

scientific article published on 09 July 2019

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

scientific article

Phosphomimetic substitution of cytochrome C tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation

scientific article published in August 2010

Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE

scientific article

Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease

scientific article

Publisher Correction: Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury.

scientific article published on 25 April 2018

Radiosensitization of pancreatic cancer cells by metformin through the AMPK pathway

scientific article

Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation

scientific article published on 01 November 2019

Regulation of energy transduction and electron transfer in cytochrome c oxidase by adenine nucleotides

scientific article published in February 1998

Regulation of mitochondrial oxidative phosphorylation through cell signaling

scientific article published on December 2007

Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation

scientific article

Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease.

scientific article published on 09 October 2008

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

scientific article

Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity

scientific article published on 28 September 2019

Similar skeletal muscle angiogenic and mitochondrial signalling following 8 weeks of endurance exercise in mice: discontinuous versus continuous training.

scientific article

Smooth, an hnRNP-L Homolog, Might Decrease Mitochondrial Metabolism by Post-Transcriptional Regulation of Isocitrate Dehydrogenase (Idh) and Other Metabolic Genes in the Sub-Acute Phase of Traumatic Brain Injury.

scientific article published on 15 November 2017

Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism

scientific article published on 19 March 2013

TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages

scientific article published on 6 February 2012

TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy

scientific article published on 18 March 2012

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice

scientific article

The cDNA sequences of cytochrome c oxidase subunit VIa from carp and rainbow trout suggest the absence of isoforms in fishes

scientific article published in March 1997

The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.

scientific article

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis

journal article published in 2011

The possible role of isoforms of cytochrome c oxidase subunit VIa in mammalian thermogenesis.

scientific article published in August 1999

The subunit composition and function of mammalian cytochrome c oxidase

scientific article published on 16 July 2015

Theophylline treatment improves mitochondrial function after upper cervical spinal cord hemisection

scientific article

Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease

scientific article

Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis

Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element.

scientific article

Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase

scientific article

Turkey cytochrome c oxidase contains subunit VIa of the liver type associated with low efficiency of energy transduction

scientific article published in April 2000

Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.

scientific article

cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity

scientific article

List of works by Maik Hüttemann

(-)-Epicatechin Attenuates Degradation of Mouse Oxidative Muscle Following Hindlimb Suspension.

(-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice

(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity

(-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining

A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction

A suggested role for mitochondria in Noonan syndrome.

A third isoform of cytochrome c oxidase subunit VIII is present in mammals

Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates

Aerobic exercise preconception and during pregnancy enhances oxidative capacity in the hindlimb muscles of mice offspring

Antisense techniques provide robust decrease in GnRH receptor expression with minimal cytotoxicity in GT1-7 cells

Biochemical defects and genetic abnormalities in cytochrome c oxidase of patients with Leigh syndrome.

Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation

COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy

Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae

Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

Clinical Benefits of Remote Ischemic Preconditioning

Coadaptive evolution in cytochrome c oxidase: 9 of 13 subunits show accelerated rates of nonsynonymous substitution in anthropoid primates

Corrigendum to "Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function" [Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1864/5(2019) 654-661]

Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines

Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment

Cytochrome C oxidase and the regulation of oxidative phosphorylation.

Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

Cytochrome c oxidase-modulatory near-infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury

Cytochrome c oxidase: evolution of control via nuclear subunit addition

Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation

Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome

Different proteolipid protein mutants exhibit unique metabolic defects

Discovering the phosphoproteome of the hydrophobic cytochrome c oxidase membrane protein complex.

Diverse system stresses: common mechanisms of chromosome fragmentation.

EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming

Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis

Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation

Epidermal growth factor receptor translocation to the mitochondria: regulation and effect

Evolution of the couple cytochrome c and cytochrome c oxidase in primates

Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model

HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer

Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency

Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats

Inhibiting Mitochondrial Cytochrome <i>c</i> Oxidase Downregulates Gene Transcription After Traumatic Brain Injury in <i>Drosophila</i>

Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury

Insertion of proteolipid protein into mitochondria but not DM20 regulates metabolism of cells

Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphate

Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene

Isolation of regulatory-competent, phosphorylated cytochrome C oxidase.

Letter by Hüttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction"

Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells

Loss of tafazzin results in decreased myoblast differentiation in C2C12 cells: A myoblast model of Barth syndrome and cardiolipin deficiency

Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism

MNRR1, a Biorganellar Regulator of Mitochondria.

Mammalian liver cytochrome c is tyrosine-48 phosphorylated in vivo, inhibiting mitochondrial respiration

Mammalian subunit IV isoforms of cytochrome c oxidase

Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity

MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes

Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy.

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans

Mitochondrial Structure, Function, and Dynamics: The Common Thread across Organs, Disease, and Aging.

Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy.

Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase

Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation

Multiple phosphorylations of cytochrome c oxidase and their functions

Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation

New Prospects for an Old Enzyme: Mammalian CytochromecIs Tyrosine-Phosphorylated in Vivo†

Non-invasive treatment with near-infrared light: A novel mechanisms-based strategy that evokes sustained reduction in brain injury after stroke

Norethindrone is superior to combined oral contraceptive pills in short-term delay of menses and onset of breakthrough bleeding: a randomized trial

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

Phosphomimetic substitution of cytochrome C tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation

Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE

Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease

Publisher Correction: Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury.