List of works - David S. Nirschl

2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis

scientific article published on 14 March 2008

A computational method for planning complex compound distributions under container, liquid handler, and assay constraints

scientific article

Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification

scientific article published on 27 August 2012

Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.

scientific article published in September 2006

Dihydroxylation of Polyenes Using Narasaka's Modification of the Upjohn Procedure ⬇️

scientific article published on October 16, 1998

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors

scientific article published on 22 June 2012

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

scientific article published on 06 January 2014

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

scientific article published on 23 January 2017

Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.

scientific article

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

scientific article

End-to-End Sample Tracking in the Laboratory Using a Custom Internet of Things Device

scientific article published on 17 July 2018

Enhancing the reagent selection workflow via real-time vendor inventory

scientific article published on 01 March 2009

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

scientific article

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors

scientific article published on 09 August 2012

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase

scientific article

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.

scientific article

Leveraging a "Catch-Release" Logic Gate Process for the Synthesis and Nonchromatographic Purification of Thioether- or Amine-Bridged Macrocyclic Peptides.

scientific article published on 14 March 2018

Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

scientific article published on 05 October 2011

Orthogonality of SFC versus HPLC for small molecule library separation.

scientific article

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

scientific article

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3

scientific article

Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds

scientific article

List of works by David S. Nirschl

2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis

A computational method for planning complex compound distributions under container, liquid handler, and assay constraints

Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification

Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.

Dihydroxylation of Polyenes Using Narasaka's Modification of the Upjohn Procedure ⬇️

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

End-to-End Sample Tracking in the Laboratory Using a Custom Internet of Things Device

Enhancing the reagent selection workflow via real-time vendor inventory

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.

Leveraging a "Catch-Release" Logic Gate Process for the Synthesis and Nonchromatographic Purification of Thioether- or Amine-Bridged Macrocyclic Peptides.

Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

Orthogonality of SFC versus HPLC for small molecule library separation.

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3

Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds