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List of works by Paul P Geurink

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

scientific article published on 22 September 2017

A MALDI-TOF Approach to Ubiquitin Ligase Activity

scientific article published on 01 September 2018

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

scientific article published on 04 September 2020

A cleavable linker based on the levulinoyl ester for activity-based protein profiling

scientific article published on September 2010

A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents

scientific article published on 23 December 2011

A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol

scientific article

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

scientific article published on 01 May 2011

Activity-Dependent Photoaffinity Labeling of Metalloproteases

scientific article published in January 2017

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

scientific article

Catching a DUB in the act: novel ubiquitin-based active site directed probes

scientific article

Design of Peptide Hydroxamate-Based Photoreactive Activity-Based Probes of Zinc-Dependent Metalloproteases

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

scientific article published on 19 December 2019

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

scientific article published on 21 March 2016

Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell

scientific article published in 2024

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

scientific article published on 22 February 2016

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

scientific article

Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes

scientific article published on 01 February 2009

Identification and characterization of diverse OTU deubiquitinases in bacteria

scientific article published on 22 June 2020

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach

article

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

scientific article

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites

scientific article published on March 2010

Inhibition of papain-like protease PLpro blocks SARS-CoV-2 spread and promotes anti-viral immunity

scientific article published on 5 May 2020

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation

scientific article published on 27 December 2017

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

scientific article published on 20 February 2018

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

scientific article published in Nature Communications

Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

scientific article published on 30 June 2020

Mechanism and inhibition of SARS-CoV-2 PLpro

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

scientific article published on 26 August 2020

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

scientific article

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15

scientific journal article

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation

scientific article published on 01 August 2018

Nature of pharmacophore influences active site specificity of proteasome inhibitors

scientific article

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

scientific article

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

scientific article

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

scientific article

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

scientific article published on 29 July 2020

Photoaffinity labeling in activity-based protein profiling

scientific article published on January 2012

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

scientific article

Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates

scientific article published on 27 October 2010

Profiling DUBs and Ubl-specific proteases with activity-based probes

scientific article published on 14 February 2019

Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors

scientific article

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

scientific article published on 22 May 2019

Solid-Phase Synthesis of Succinylhydroxamate Peptides:  Functionalized Matrix Metalloproteinase Inhibitors

scientific article published in 2006

Structural basis of the specificity of USP18 toward ISG15.

scientific article

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

scientific article published on 01 December 2011

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

scientific article published on 13 July 2016

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells

scientific article published on 23 June 2015

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

scientific article

Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties

scientific article published on 11 November 2019

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