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List of works by Janet J. Maguire

A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

article

A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29

scientific article published on 01 May 2020

Advances in therapeutic peptides targeting G protein-coupled receptors

scientific article published on 19 March 2020

Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis

scientific article published on 18 September 2014

Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels

scientific article

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

scientific article published in September 2015

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

scientific article

Cardiac action of the first G protein biased small molecule apelin agonist ⬇️

scientific article published on 27 July 2016

Changes in biomechanical properties of the coronary artery wall contribute to maintained contractile responses to endothelin-1 in atherosclerosis

scientific article published on 8 April 2014

Characterization of [¹²⁵I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta

scientific article published on 15 March 2014

Characterization of the snake venom ligand [125I]-DNP binding to natriuretic peptide receptor-A in human artery and potent DNP mediated vasodilatation.

scientific article published on 16 October 2006

Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

scientific article

Chemokine receptor CCR5: from AIDS to atherosclerosis

scientific article

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

scientific article published on 22 May 2008

Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice

scientific article published on 18 February 2012

Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways

scientific article published on 27 March 2012

Comparison of the vasoconstrictor effects of rizatriptan and sumatriptan in human isolated cranial arteries: immunohistological demonstration of the involvement of 5-HT1B-receptors

scientific article published on December 1998

Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues

scientific article published on 23 May 2012

Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist

scientific article

Discovering orphan receptor function using human in vitro pharmacology.

scientific article

Discovery of a competitive apelin receptor (APJ) antagonist.

scientific article published on 10 May 2011

Discovery of recently adopted orphan receptors for apelin, urotensin II, and ghrelin identified using novel radioligands and functional role in the human cardiovascular system.

scientific article

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

scientific article published on 30 January 2017

Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelin(A), but not endothelin(B), receptors in an animal model of hypertension.

scientific article published in August 2002

Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S

scientific article

Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1.

scientific article

Endothelin

scientific article

Endothelin converting enzyme (ECE) activity in human vascular smooth muscle

scientific article

Endothelin receptor expression and pharmacology in human saphenous vein graft

scientific article

Endothelin receptors and their antagonists

scientific article

Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer.

scientific article published on January 2013

Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin

scientific article published on 01 June 2006

Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12

scientific article (publication date: December 2014)

Evidence for a novel vasospastic transmitter system, neuromedin U, in the equine digital circulation

scientific article

Evidence for biased agonists and antagonists at the endothelin receptors

scientific article published on 17 February 2016

Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system

scientific article

Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man.

scientific article

G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors.

scientific article published in August 2002

Identification and cellular localisation of NPW1 (GPR7) receptors for the novel neuropeptide W-23 by [125I]-NPW radioligand binding and immunocytochemistry

scientific article

Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: Relevance to function

scientific article published on 26 August 2007

Increased response to big endothelin-1 in atherosclerotic human coronary artery: functional evidence for up-regulation of endothelin-converting enzyme activity in disease.

scientific article

Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor

scientific article

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function

scientific article published on 06 July 2010

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function

scientific article

International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature

scientific article

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

scientific journal article

Is urotensin-II the new endothelin?

scientific article

Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels

scientific article published on 5 October 2006

Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

scientific article

LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal

scientific article published on 27 April 2015

Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension

scientific article

Modulation of the apelin/APJ system in heart failure and atherosclerosis in man

scientific article

Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure

scientific article published on 15 June 2006

Of mice and men: advances in endothelin research and first antagonist gains FDA approval

scientific article

Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1

scientific article

Pharmacology of renal endothelin receptors

scientific article published on August 30, 2011

Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver

scientific article

Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice.

scientific article

Radioligand Binding Assays and Their Analysis

article

Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation

scientific article published on March 2006

Regulation of vascular reactivity by established and emerging GPCRs

scientific article published in September 2005

The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro.

scientific article published on 09 December 2013

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans

scientific article published on 28 March 2012

The endothelin system in human saphenous vein graft disease

scientific article

The therapeutic potential of PD156707 and related butenolide endothelin antagonists

scientific article published in January 1999

Vasoconstrictor activity of novel endothelin peptide, ET-1(1 - 31), in human mammary and coronary arteries in vitro

scientific article

Vasoconstrictor endothelin receptors characterized in human renal artery and vein in vitro

scientific article

[Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.

scientific article published on 28 February 2017

[Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease.

scientific article published on 13 July 2009

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