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List of works by Arie O. Verkerk

'Mature' resting membrane potentials in human-induced pluripotent stem cell-derived cardiomyocytes: fact or artefact?

scientific article published on 03 October 2019

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

scientific article published on 17 November 2017

A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a Rabbit Model of Pressure and Volume Overload

scientific article published on 02 April 2012

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization

scientific article published on 01 July 2003

Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes

scientific article published on 01 December 2019

Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation

scientific article published on 04 September 2019

Acetylsalicylic acid prevents platelet-induced proarrhythmic effects on intracellular Ca2+ homeostasis in ventricular myocytes

scientific article published on 16 October 2012

Activated human platelet products induce proarrhythmic effects in ventricular myocytes

scientific article published on 30 May 2011

Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.

scientific article

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.

scientific article

Aquaporin Channels in the Heart-Physiology and Pathophysiology

scientific article published on 25 April 2019

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.

scientific article published on 19 February 2015

Biphasic response of action potential duration to metabolic inhibition in rabbit and human ventricular myocytes: role of transient outward current and ATP-regulated potassium current

scientific article published on 01 December 1996

Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.

scientific article published on 2 February 2015

Ca(2+)-activated Cl(-) current in rabbit sinoatrial node cells.

scientific article

Ca2+-activated Cl- current reduces transmural electrical heterogeneity within the rabbit left ventricle.

scientific article published in March 2004

Calcium transient and sodium-calcium exchange current in human versus rabbit sinoatrial node pacemaker cells

scientific article published on 24 February 2013

Calcium-activated Cl(-) current contributes to delayed afterdepolarizations in single Purkinje and ventricular myocytes

scientific article published on 01 June 2000

Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.

scientific article published on 6 July 2017

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

article

Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease

scientific article published on 30 May 2012

Cellular basis of sex disparities in human cardiac electrophysiology

scientific article published in August 2006

Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding

scientific article published on 31 July 2015

Chronic inhibition of the Na+/H+ - exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling.

scientific article published on 19 May 2008

Cl(-) current blockade reduces triggered activity based on delayed afterdepolarisations

scientific article published on August 2001

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scientific article

Computational model of rabbit SA node pacemaker activity probed with action potential and calcium transient clamp

scientific article published in January 2007

Conduction slowing by the gap junctional uncoupler carbenoxolone

scientific article published in November 2003

Considerations in studying the transient outward K(+) current in cells exhibiting the hyperpolarization-activated current

scientific article published in December 2001

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia

scientific article

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

scientific article published on 07 January 2020

Dietary Omega-3 Polyunsaturated Fatty Acids Suppress NHE-1 Upregulation in a Rabbit Model of Volume- and Pressure-Overload

scientific article published on 2 April 2012

Dietary fish oil reduces pacemaker current and heart rate in rabbit

scientific article published on 16 July 2009

Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes

scientific article published on 17 July 2007

Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes

scientific article published on 11 September 2006

Differential effects on out-of-hospital cardiac arrest of dihydropyridines: real-world data from population-based cohorts across two European countries

scientific article published on 10 August 2019

Disease Modifiers of Inherited Channelopathy

scientific article published on 01 October 2018

Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation.

scientific article published on January 2007

Down the rabbit hole: deciphering the short QT syndrome

scientific article published on 01 March 2019

Dynamic action potential clamp as a powerful tool in the development of a gene-based bio-pacemaker.

scientific article

Dynamic clamp as a tool to study the functional effects of individual membrane currents

Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias

scientific article published in October 2015

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration

scientific article published on 20 September 2012

Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes

scientific article

Effects of endotoxin on pacemaker funny current in HEK 293 cells

Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes

scientific article published on 19 June 2007

Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells.

scientific article published on 29 July 2009

Electrophysiologic Remodeling of the Left Ventricle in Pressure Overload-Induced Right Ventricular Failure

scientific article published on 01 June 2012

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates

scientific article published on 08 April 2020

Electrophysiological changes in heart failure and their implications for arrhythmogenesis

scientific article

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

scientific article published on 03 September 2018

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer

scientific article

Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy

scientific article published on 01 July 2018

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scholarly article published in Nature Genetics

Etiology-dependency of ionic remodeling in cardiomyopathic rabbits

scientific article published on 17 November 2009

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.

scientific article

Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome.

scientific article

Fish oil curtails the human action potential dome in a heterogeneous manner: implication for arrhythmogenesis

scientific article published on 26 November 2007

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology

scientific article published on 20 June 2012

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation

scientific article published on 29 January 2017

Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes

scientific article published in November 2005

Gender disparities in torsade de pointes ventricular tachycardia.

scientific article

Gene expression profiling of the forming atrioventricular node using a novel tbx3-based node-specific transgenic reporter

scientific article published on 4 June 2009

Genetic control of sodium channel function

scientific article

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh)

scientific article published on 09 July 2019

Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy

scientific article published on 30 April 2009

HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy

scientific article published in August 2014

HERG channel (dys)function revealed by dynamic action potential clamp technique

scientific article

Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations.

scientific article

Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells

scientific article

Identification and functional characterization of cardiac pacemaker cells in zebrafish

scientific article (publication date: 2012)

Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient.

scientific article published on 26 July 2018

Identification of swelling-activated Cl(-) current in rabbit cardiac Purkinje cells.

scientific article published in May 2004

Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

scientific article published on 25 February 2015

Incorporated Fish Oil Fatty Acids Prevent Action Potential Shortening Induced by Circulating Fish Oil Fatty Acids ⬇️

scientific article published on November 22, 2010

Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials

scientific article published on 28 February 2006

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

scientific article

Injury current modulates afterdepolarizations in single human ventricular cells.

scientific article

Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

scientific article

Intracardiac origin of heart rate variability, pacemaker funny current and their possible association with critical illness.

scientific article published on February 2013

Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes.

scientific article published on October 2008

Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia

scientific article published on 01 September 2003

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1.

scientific article

Ionic Mechanism of Delayed Afterdepolarizations in Ventricular Cells Isolated From Human End-Stage Failing Hearts ⬇️

scientific article published on November 27, 2001

Ionic remodeling of sinoatrial node cells by heart failure

scientific article published on 28 July 2003

Is sodium current present in human sinoatrial node cells?

scientific article published on 13 February 2009

KV4.3 Expression Modulates NaV1.5 Sodium Current.

scientific article published on 12 March 2018

Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration.

scientific article published on 6 February 2006

Limited role of Ca(2+)-activated Cl(-) current in early afterdepolarisations

scientific article published on December 2002

Long QT Syndrome and Sinus Bradycardia-A Mini Review

article

Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique.

scientific article

Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch.

scientific article published on 12 October 2009

Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K channel

scientific article published in Nature Communications

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

scientific article

Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD

scientific article

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

scientific article

Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current

scientific article

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current

scientific article published on March 2014

Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f).

scientific article

Pacemaker current (I(f)) in the human sinoatrial node.

scientific article

Pacing Discovery: G-Protein β Subunit Mutations in Sinus Node Dysfunction

scientific article published in May 2017

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp

scientific article published on 30 August 2017

Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy

scientific article published on 15 December 2017

Pro- and antiarrhythmic properties of a diet rich in fish oil.

scientific article

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.

scientific article published on 12 April 2018

Re-evaluation of the action potential upstroke velocity as a measure of the Na+ current in cardiac myocytes at physiological conditions

scientific article

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.

scientific article published in November 2016

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue

scientific article

Reconstituted High-Density Lipoprotein Shortens Cardiac Repolarization

scientific article published on 01 June 2011

Reduced swelling-activated Cl(-) current densities in hypertrophied ventricular myocytes of rabbits with heart failure

scientific article

Relative importance of funny current in human versus rabbit sinoatrial node

scientific article published on 11 January 2010

Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations

scientific article published on 20 March 2015

Response by Veerman et al to Letter Regarding Article, "The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity"

scientific article published on 01 August 2017

Response to Letter Regarding Article “Acute Administration of Fish Oil Inhibits Triggered Activity in Isolated Myocytes From Rabbits and Patients With Heart Failure”

Revised roles of ISL1 in a hES cell-based model of human heart chamber specification.

scientific article published on 16 January 2018

Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study.

scientific article published on November 2005

Role of Ca(2+)-activated Cl(-) current in ventricular action potentials of sheep during adrenoceptor stimulation.

scientific article

Role of Ca2+-activated Cl- current during proarrhythmic early afterdepolarizations in sheep and human ventricular myocytes.

scientific article published in October 2003

Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome

scientific article

Role of the R1135H KCNH2 mutation in Brugada syndrome

scientific article published on 27 January 2009

Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

scientific article published on 08 June 2020

Sex-deparities in cardiac electrophysiology: L-type Ca2+ current and the Na+-Ca2+ exchanger go hand in hand.

scientific article published on March 2011

Single 5-HT3 receptor-gated ion channel events resolved in N1E-115 mouse neuroblastoma cells

scientific article published on 01 February 1994

Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current.

scientific article published on January 2007

Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome

scientific article published on 31 August 2013

Sodium current inhibition by nanosecond pulsed electric field (nsPEF)--fact or artifact?

scientific article published on 07 September 2012

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning

scientific article

Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease-Causing Mutation

scientific article published on 24 July 2017

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

scientific article published on 14 March 2012

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

scientific article

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

scientific article

The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.

scientific article published on 21 June 2017

The chemical compound PTC124 does not affect cellular electrophysiology of cardiac ventricular myocytes.

scientific article published on February 2012

The sodium channel NaV 1.5 impacts on early murine embryonic cardiac development, structure, and function in a non-electrogenic manner

scientific article published on 09 May 2020

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

scientific article published on 25 April 2019

Two types of action potential configuration in single cardiac Purkinje cells of sheep

scientific article published on 01 October 1999

Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.

scientific article published on 26 March 2013

Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia

scientific article published on 20 April 2020

Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders ⬇️

scientific article published on July 10, 2012

hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

scientific article published on 03 August 2016

shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele

scientific article published in 2022

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