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List of works by Ruslan Medzhitov

A New Shield for a Cytokine Storm ⬇️

scientific article published on September 16, 2011

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages ⬇️

scientific article published on April 21, 2011

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system

scientific article

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity ⬇️

scientific article (publication date: 24 July 1997)

A mechanism for the initiation of allergen-induced T helper type 2 responses

scientific article

A plague on host defense

scientific article published on October 2002

A role for the ITAM signaling module in specifying cytokine-receptor functions

scientific journal article

ART and immunology

scientific article published on 23 September 2014

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.

scientific article

Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids

scientific article published on 06 July 2020

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity

scientific article published on March 2002

Age-associated defect in human TLR-1/2 function

scientific article published on 01 January 2007

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway

scientific article

Allergic host defences ⬇️

scientific article published on April 25, 2012

Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites

scientific article published on 01 October 1999

An ancient system of host defense ⬇️

scientific article published on February 1, 1998

An evolutionary perspective on immunometabolism

scientific article published on 01 January 2019

Analysis of gene-environment interactions in postnatal development of the mammalian intestine

scientific article

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.

scientific article

Antifungal defense turns 17

scientific article published on 01 June 2007

Antiviral defense: interferons and beyond

scientific article

Approaching the asymptote: 20 years later

scientific article

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

scientific article

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity

scientific article published on 24 October 2013

Bringing Warburg to lymphocytes

scientific article published on 01 October 2015

Circuit Design Features of a Stable Two-Cell System

scientific article published on 30 January 2018

Control of B-cell responses by Toll-like receptors

scientific article published in Nature

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells

scientific article

Control of adaptive immune responses by Toll-like receptors.

scientific article

Control of adaptive immunity by the innate immune system

scientific article

Control of inducible gene expression by signal-dependent transcriptional elongation

scientific article published on July 2009

Control of infection by pyroptosis and autophagy: role of TLR and NLR.

scientific article

Control strategies in systemic metabolism

scientific article published on 07 October 2019

Counting Calories: The Cost of Inflammation

scientific article published on 01 April 2019

CpG DNA: security code for host defense

scientific article published on 01 January 2001

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

scientific article

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury

scientific article

Damage control in host-pathogen interactions

scientific article published on 09 September 2009

Danger - pathogen on the premises! Immunological tolerance

scientific article

Decoding the patterns of self and nonself by the innate immune system

scientific article (publication date: 12 April 2002)

Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response

scientific article published on 05 March 2019

Disease tolerance as a defense strategy

scientific article

Drosophila MyD88 is an adapter in the Toll signaling pathway

scientific article

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

scientific article

Editorial overview: Innate immunity

scholarly article by Eric Vivier & Ruslan Medzhitov published February 2016 in Current Opinion in Immunology

Emerging Principles of Gene Expression Programs and Their Regulation

scientific article published on 01 August 2018

Emerging functions of basophils in protective and allergic immune responses

scientific article published on 13 January 2010

Endocytosis as a stabilizing mechanism for tissue homeostasis.

scientific article published on 2 February 2018

Erratum: Corrigendum: Integration of cytokine and heterologous receptor signaling pathways

scholarly article by Jelena S Bezbradica & Ruslan Medzhitov published June 2009 in Nature Immunology

Evolution of inflammatory diseases

scientific article published on September 2012

Evolutionary perspective on innate immune recognition

scientific article

Fly immunity: great expectations

scientific article

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

scientific article published on September 2016

Functional categories of immune inhibitory receptors

scientific article published on 01 July 2020

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

scientific article

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells

scientific article published on 04 February 2014

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

scientific article published on 08 August 2019

GENE EXPRESSION. Unwinding inducible gene expression

scientific article published on 01 May 2016

Gene-specific control of inflammation by TLR-induced chromatin modifications

scientific article published in Nature

Gene-specific control of the TLR-induced inflammatory response

scientific article published on 28 October 2008

Germs gone wild ⬇️

scientific article published on May 4, 2012

Glucose metabolism mediates disease tolerance in cerebral malaria

article published in the Proceedings of the National Academy of Sciences of the United States of America

HIV immunology needs a new direction

scientific article published on 01 October 2008

Harnessing innate immunity in cancer therapy

scientific article published on 02 October 2019

Highlights of 10 years of immunology in Nature Reviews Immunology

scientific article published on 23 September 2011

Homeostasis, inflammation, and disease susceptibility

scientific article

Honor thy Go(na)ds.

scientific article published on 24 September 2013

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes ⬇️

scientific article published on May 27, 2011

Host-microbe interactions: fulfilling a niche

scientific article

How does the immune system distinguish self from nonself?

scientific article published on 01 June 2000

How the immune system spots tumors

scientific article published on 24 September 2014

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

scientific journal article

IRAK-M is a negative regulator of Toll-like receptor signaling

scientific article

Immunostimulatory activity of haptenated proteins

scholarly article

Impact of CD1d deficiency on metabolism.

scientific article

Infection and inflammation in somatic maintenance, growth and longevity

scientific article

Inflammation 2010: new adventures of an old flame

scientific article

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

scientific article published on 10 July 2017

Inflammation: Memory beyond immunity

scientific article published on 18 October 2017

Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection

scientific article

Innate control of adaptive immunity via remodeling of lymph node feed arteriole

scientific article

Innate immune induction of the adaptive immune response

scientific article

Innate immune recognition

scientific article (publication date: 2002)

Innate immune recognition and control of adaptive immune responses

scientific article published on 01 October 1998

Innate immune recognition of the indigenous microbial flora

scientific article

Innate immune recognition: mechanisms and pathways

scientific article (publication date: February 2000)

Innate immunity

scientific article (publication date: 3 August 2000)

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines

scientific article published on 8 December 2006

Innate immunity: impact on the adaptive immune response

scientific article published on February 1997

Innate immunity: quo vadis?

scientific article published on 01 July 2010

Innate sensors of microbial infection

scientific article

Innovating immunology: an interview with Ruslan Medzhitov ⬇️

scientific article published on July 1, 2011

Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin

scientific article published on 15 April 2015

Integration of cytokine and heterologous receptor signaling pathways

scientific article published on 19 March 2009

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease ⬇️

scientific article published on May 1, 2011

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

scientific article published on 11 December 2005

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.

scholarly article

Introduction: the role of innate immunity in the adaptive immune response

Investigate the origins of COVID-19

scientific article

Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors

scientific article published in April 2000

Learning tolerance while fighting ignorance

scientific article published in August 2009

Linking Toll-like receptors to IFN-alpha/beta expression

scientific article published on 01 May 2003

Lipoproteins take their toll on the host

scientific article published on 01 December 1999

Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids

scientific article published on 01 March 2020

Longitudinal analyses reveal immunological misfiring in severe COVID-19

scientific article published on 27 July 2020

Longitudinal immunological analyses reveal inflammatory misfiring in severe COVID-19 patients

scientific article

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

scientific article published on 11 May 2015

Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis

scientific article

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

scientific article published on October 2009

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

scientific article

NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway

scientific article published on 21 October 2007

Not so fast: adaptive suppression of innate immunity

scientific article published on 01 October 2007

Not the usual suspect: type I interferon-responsive T cells drive infection-induced cachexia

scientific article published on 01 June 2019

On regulation of phagosome maturation and antigen presentation

scientific article published on October 2006

On the semantics of immune recognition

scientific article published on May 1996

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

scientific article published on September 2016

Origin and physiological roles of inflammation

scientific article (publication date: 24 July 2008)

Pattern recognition receptors and control of adaptive immunity

scientific article published on January 2009

Pattern recognition theory and the launch of modern innate immunity

scientific article

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

scientific journal article

Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults

article

Principles of Cell Circuits for Tissue Repair and Fibrosis

scientific article published on 16 January 2020

Prostaglandin-secreting cells: a portable first aid kit for tissue repair

scientific article published on January 2007

Publisher Correction: Harnessing innate immunity in cancer therapy

scientific article published on 01 December 2019

Pyroptosis: Macrophage Suicide Exposes Hidden Invaders ⬇️

scientific article published on January 25, 2011

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

scientific article

RUNX binding sites are enriched in herpesvirus genomes and RUNX1 overexpression leads to HSV-1 suppression

scientific article published on 02 September 2020

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

scientific article published on 01 September 2000

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

scientific article (publication date: 23 July 2004)

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

scientific article (publication date: 2006)

Recognition of microbial infection by Toll-like receptors

scientific article

Recognition of microorganisms and activation of the immune response

scientific article (publication date: 18 October 2007)

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence

scientific article

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide

scientific journal article

Regulation of adaptive immunity by the innate immune system

scientific article

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

scientific article

Regulation of phagosome maturation by signals from toll-like receptors

scientific article

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

scientific journal article

Retroviral delivery of small interfering RNA into primary cells

scientific article

Role of ITAM signaling module in signal integration

scientific article published on 11 January 2012

Role of basophils in the initiation of Th2 responses

scientific article published on 09 February 2010

Role of caspase-1 in regulation of triglyceride metabolism.

scientific article published on 4 March 2013

Role of the inflammasome in defense against venoms

scientific article published on 7 January 2013

Role of the innate immune system and host-commensal mutualism.

scientific article published on January 2006

Role of tissue protection in lethal respiratory viral-bacterial coinfection

scientific article published on 25 April 2013

Role of toll-like receptors in spontaneous commensal-dependent colitis

scientific article published on 03 August 2006

Role of toll-like receptors in tissue repair and tumorigenesis

scientific article published on May 2008

Ruslan Medzhitov: Meet the winner of the Else Kröner-Fresenius Award in 2013.

scientific article published in November 2013

Self-defense: The fruit fly style ⬇️

scientific article published on January 20, 1998

Semaphorin 7A is a negative regulator of T cell responses

scientific article published in May 2006

Septic shock: on the importance of being tolerant.

scientific article

Signaling pathways activated by a protease allergen in basophils

scientific article

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells

scientific article published on January 2014

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus

scientific article published on 14 March 2013

Skin antibiotics get in the loop

scientific article published on 01 December 2002

Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice

scientific article published on 23 January 2019

Stress, inflammation, and defense of homeostasis

scientific article

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

scientific article

T cell-intrinsic role of IL-6 signaling in primary and memory responses

scientific article

T helper 17 cells get the NOD.

scientific article

TLR-mediated innate immune recognition ⬇️

scientific article published on February 1, 2007

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease

scientific article published on November 2006

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

scientific journal article

Targeting of immune signalling networks by bacterial pathogens

scientific article published on May 2009

The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia

scientific article published on 16 March 2016

The Toll receptor family and microbial recognition

scientific article

The Toll-receptor family and control of innate immunity

scientific article

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

scientific journal article

The control of adaptive immune responses by the innate immune system

scientific article published on January 2011

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter

scientific article published on 10 June 2013

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

scientific article published on 03 January 2014

The orientation of a T cell receptor to its MHC class II:peptide ligands ⬇️

scientific article published on November 1, 1997

The origins of tumor-promoting inflammation.

scientific article published on August 2013

The specificity and orientation of a TCR to its peptide-MHC class II ligands

scientific journal article

Tissue biology perspective on macrophages

scientific article

Tissue-specific signals control reversible program of localization and functional polarization of macrophages

scientific article

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

scientific article

Toll signaling: RIPping off the TNF pathway

scientific article published in May 2004

Toll-dependent control mechanisms of CD4 T cell activation

scientific article published in November 2004

Toll-dependent selection of microbial antigens for presentation by dendritic cells

scientific article published in Nature

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

scientific article

Toll-like receptor control of the adaptive immune responses

scientific article (publication date: October 2004)

Toll-like receptor signaling pathways

scientific article

Toll-like receptors and acquired immunity

scientific article published on February 2004

Toll-like receptors and antibody responses (Reply)

scientific article published in Nature

Toll-like receptors and cancer

scientific article published on 04 December 2008

Toll-like receptors and innate immunity

scientific article (publication date: November 2001)

Toll-like receptors and their ligands.

scientific article

Toll-like receptors and their role in experimental models of microbial infection

scientific article

Toll-like receptors: balancing host resistance with immune tolerance

scientific article published on December 2003

Toll-like receptors: linking innate and adaptive immunity

scientific article

Toll-like receptors: linking innate and adaptive immunity

scientific article published on 01 January 2005

Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

scientific article

Training the next generation of biomedical investigators in glycosciences

scientific article published on February 2016

Transcriptional control of the inflammatory response

scientific article published on October 2009

Trex1 prevents cell-intrinsic initiation of autoimmunity

scientific article

Triggering TLR signaling in vaccination

scientific article

Two modes of ligand recognition by TLRs

scientific article published on September 2007

Two-signal requirement for growth-promoting function of Yap in hepatocytes

scientific article

Type I interferons in host defense

scientific article (publication date: September 2006)

Untangling iNKT Cell Function in Adipose Tissue Homeostasis

scientific article published on 01 August 2020

Viral interference with IL-1 and toll signaling

scientific article

Vitamin B12 and folic acid alleviate symptoms of nutritional deficiency by antagonizing aryl hydrocarbon receptor

scientific article published on 22 June 2020

Wormhole Travel for Macrophages.

scientific article published in April 2016

graal: a Drosophila gene coding for several mosaic serine proteases

scientific article published in October 2004

p53-mediated hematopoietic stem and progenitor cell competition.

scientific article

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