List of works - Patricia Melnyk

6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands

scientific article

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

scientific article published on 17 March 2022

Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity

scientific article published on 5 December 2017

Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands

scientific article published on 18 October 2014

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

scientific article

Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

scientific article published on 30 April 2018

Formulation and characterization of polyphenol-loaded lipid nanocapsules.

scientific article published on 6 June 2009

High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis.

scientific article

Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches.

scientific article

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives

scientific article published on 29 December 2015

Minimal chemical modification of reductive end of dextran to produce an amphiphilic polysaccharide able to incorporate onto lipid nanocapsules

scientific article published on 21 June 2008

Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

scientific article published on 23 March 2017

New synthesis of tic-hydantoins sigma-1 ligands and pharmacological evaluation on cocaine-induced stimulant effects.

scientific article published on November 2010

Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke.

scientific article published on 6 May 2014

Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity.

scientific article

Sigma-1 ligands: Tic-hydantoin as a key pharmacophore.

scientific article published on 9 October 2009

Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.

scientific article published on 19 November 2007

Synthesis and antimalarial activity of new amino analogues of amodiaquine.

scientific article published on September 2008

Synthesis and antimalarial activity of new analogues of amodiaquine

scientific article published on 3 April 2007

Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands.

scientific article published on 12 July 2017

Synthesis and pharmacological evaluation of dual ligands for melatonin (MT1/MT2) and serotonin 5-HT2C receptor subtypes (II).

scientific article published on 13 December 2014

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker

scientific article published on 25 August 2012

Tic hydantoin sigma-1 agonist: pharmacological characterization on cocaine-induced stimulant and appetitive effects.

scientific article published on 26 February 2009

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

scientific article published on 8 May 2018

List of works by Patricia Melnyk

6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity

Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

Formulation and characterization of polyphenol-loaded lipid nanocapsules.

High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis.

Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches.

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives

Minimal chemical modification of reductive end of dextran to produce an amphiphilic polysaccharide able to incorporate onto lipid nanocapsules

Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

New synthesis of tic-hydantoins sigma-1 ligands and pharmacological evaluation on cocaine-induced stimulant effects.

Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke.

Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity.

Sigma-1 ligands: Tic-hydantoin as a key pharmacophore.

Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.

Synthesis and antimalarial activity of new amino analogues of amodiaquine.

Synthesis and antimalarial activity of new analogues of amodiaquine

Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands.

Synthesis and pharmacological evaluation of dual ligands for melatonin (MT1/MT2) and serotonin 5-HT2C receptor subtypes (II).

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker

Tic hydantoin sigma-1 agonist: pharmacological characterization on cocaine-induced stimulant and appetitive effects.

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.