List of works - Longqin Hu

5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation.

scientific article published in September 2003

5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation

scientific article

A Simple One-Pot Procedure for the Direct Conversion of Alcohols to Azides via Phosphate Activation

scientific article published on 01 June 2000

A convenient biphasic process for the monosilylation of symmetrical 1,n-primary diols

A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates.

scientific article

Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor

scientific article

An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs

scientific article

Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling

scientific article published on 30 December 2008

Benextramine-neuropeptide Y (NPY) binding site interactions: characterization of 3H-NPY binding site heterogeneity in rat brain

scientific article published on November 1992

Cystinuria: genetic aspects, mouse models, and a new approach to therapy

scientific article published on 04 December 2018

Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers.

scientific article published on 24 December 2013

Design and synthesis of peptide conjugates of phosphoramide mustard as prodrugs activated by prostate-specific antigen

scientific article published on 19 April 2016

Design of anticancer prodrugs for reductive activation.

scientific article published on January 2009

Design, Synthesis, Evaluation, and Structural Studies of C2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction

scientific article published on 25 July 2019

Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.

scientific article published on July 2006

Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria

scientific article published on 10 March 2018

Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation

scientific article published on 13 September 2012

Drug Delivery

Exploiting the drug-activating properties of a novel trypanosomal nitroreductase

scientific article

Immunomodulators targeting the PD-1/PD-L1 protein-protein interaction: From antibodies to small molecules

scientific article published on 14 September 2018

Improving the Specificity of the Prostate-Specific Antigen Substrate Glutaryl-Hyp-Ala-Ser-Chg-Gln as a Promoiety.

scientific article published on 16 March 2015

In honor of Professor Lester A. Mitscher on the occasion of his 80(th) birthday.

scientific article published in July 2012

In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione

scientific article published on 17 December 2013

Insects: an underrepresented resource for the discovery of biologically active natural products

scientific article published on 30 May 2017

Monobromobimane as an affinity label of the xenobiotic binding site of rat glutathione S-transferase 3-3

scientific article published on 01 September 1995

N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard

scientific article published on 13 June 2008

Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label.

scientific article published in January 1994

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy ⬇️

scientific article published on November 6, 2003

Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture

scientific article published in September 2003

Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction

scientific article published on 10 April 2020

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.

scientific article published on 7 December 2011

Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA)

scientific article published on 25 September 2013

Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage.

scientific article published on 12 October 2006

Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization

scientific article

Probing the active site of alpha-class rat liver glutathione S-transferases using affinity labeling by monobromobimane.

scientific article

Resonance energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at cysteine-17 and cysteine-111

scientific article published on 01 February 1997

Successful Baylis-Hillman reaction of acrylamide with aromatic aldehydes

scientific article

Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA).

scientific article published on 9 March 2009

Targeted prodrug approaches for hormone refractory prostate cancer.

scientific article published on 22 December 2014

The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment.

scientific article published in August 1993

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.

scientific article published on 21 March 2015

l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.

scientific article published on 13 July 2016

List of works by Longqin Hu

5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation.

5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation

A Simple One-Pot Procedure for the Direct Conversion of Alcohols to Azides via Phosphate Activation

A convenient biphasic process for the monosilylation of symmetrical 1,n-primary diols

A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates.

Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor

An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs

Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling

Benextramine-neuropeptide Y (NPY) binding site interactions: characterization of 3H-NPY binding site heterogeneity in rat brain

Cystinuria: genetic aspects, mouse models, and a new approach to therapy

Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers.

Design and synthesis of peptide conjugates of phosphoramide mustard as prodrugs activated by prostate-specific antigen

Design of anticancer prodrugs for reductive activation.

Design, Synthesis, Evaluation, and Structural Studies of C2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction

Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.

Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria

Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation

Drug Delivery

Exploiting the drug-activating properties of a novel trypanosomal nitroreductase

Immunomodulators targeting the PD-1/PD-L1 protein-protein interaction: From antibodies to small molecules

Improving the Specificity of the Prostate-Specific Antigen Substrate Glutaryl-Hyp-Ala-Ser-Chg-Gln as a Promoiety.

In honor of Professor Lester A. Mitscher on the occasion of his 80(th) birthday.

In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione

Insects: an underrepresented resource for the discovery of biologically active natural products

Monobromobimane as an affinity label of the xenobiotic binding site of rat glutathione S-transferase 3-3

N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard

Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label.

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy ⬇️

Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture

Nrf2 activation through the inhibition of Keap1-Nrf2 protein-protein interaction

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.

Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA)

Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage.

Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization

Probing the active site of alpha-class rat liver glutathione S-transferases using affinity labeling by monobromobimane.

Resonance energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at cysteine-17 and cysteine-111

Successful Baylis-Hillman reaction of acrylamide with aromatic aldehydes

Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA).

Targeted prodrug approaches for hormone refractory prostate cancer.

The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment.

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.

l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.