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List of works by Davide Malfacini

A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.

scientific article published on 13 May 2014

Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.

scientific article

Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

scientific article published on 8 February 2016

Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo).

scientific article

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

scientific article

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

scientific article published in December 2017

In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant

scientific article published on 3 April 2015

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.

scientific article

In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.

scientific article

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.

scientific article published on 22 October 2016

In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403.

scientific article published in August 2017

Lack of beta-arrestin signaling in the absence of active G proteins.

scientific article

NOP receptor pharmacological profile - A dynamic mass redistribution study

scientific article published in PLoS ONE

Pharmacological Assays for Investigating the NOP Receptor

scientific article published on 01 January 2019

Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.

scientific article published on 6 August 2015

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

scientific article published on 02 August 2016

Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues.

scientific article published on 13 March 2014

Pharmacological characterization of tachykinin tetrabranched derivatives

scientific article

Pharmacological investigations of N-substituent variation in morphine and oxymorphone: opioid receptor binding, signaling and antinociceptive activity

scientific article

Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).

scientific article

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

scientific article published on 11 February 2019

Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.

scientific article

Synthesis and Structure-Activity Relationships of Triazaspirodecanone Derivatives as Nociceptin/Orphanin FQ Receptor Ligands

scientific article published on 20 January 2015

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor

scientific article

[d-Pen(p- t BuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies

scholarly article by Chiara Ruzza et al published 11 February 2014 in Medicinal Chemistry Research

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