List of works - Mercedes Garayoa

Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.

scientific article

Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS.

scientific article

Adrenomedullin in mammalian embryogenesis.

scientific article

Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis

scientific article

Alternative splicing of the proadrenomedullin gene results in differential expression of gene products

scientific article published in August 2001

Androgen-independent expression of adrenomedullin and peptidylglycine α-amidating monooxygenase in human prostatic carcinoma

scientific article published on 01 September 2003

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

scientific article

Biological Background of Resistance to Current Standards of Care in Multiple Myeloma

scientific article published on 13 November 2019

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

scientific article published on 24 May 2021

CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

scientific article published on 7 February 2012

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects

scientific article (publication date: 2012)

Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally.

scientific article published in February 2004

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

scientific article published on 26 September 2013

Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents

scientific article published on 04 July 2019

Downregulation of hnRNP A2/B1 expression in tumor cells under prolonged hypoxia

scientific article published in January 2003

Effects of IL-8 Up-Regulation on Cell Survival and Osteoclastogenesis in Multiple Myeloma

scientific article published on 11 June 2016

Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury.

scientific article published on 28 May 2003

Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement.

scientific article published on September 2004

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.

scientific article

Light and electron microscopic study of the hindgut of the ant (Formica nigricans, hymenoptera): I. Structure of the ileum

scientific article published on 01 December 1999

Malpighian tubules of Formica polyctena (Hymenoptera): Light and electron microscopic study

scientific article published on 01 November 1992

Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

scientific article published on 09 April 2009

Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients.

scientific article published on June 2004

Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics

scientific article

Myoendocrine-like cells in invertebrates: occurrence of noncardiac striated secretory-like myocytes in the gut of the ant Formica polyctena.

scientific article published on July 1994

Phenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines

scientific article

Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease.

scientific article published on 31 January 2014

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

scientific article published on 20 June 2017

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma

scientific article published on 18 July 2019

Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma

scientific article published on 24 September 2020

RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.

scientific article published on 7 July 2012

Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function

scientific article published on 01 January 2013

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone.

scientific article published on 18 August 2016

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

scientific article published on 18 January 2021

The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care

scientific article published on 20 July 2016

The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

scientific article published on 05 July 2012

The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.

scientific article published on 12 March 2008

The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma.

scientific article published on 31 August 2017

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

scientific article published on September 2014

Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma

scientific article published in July 2011

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.

scientific article published on 17 February 2011

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.

scientific article

List of works by Mercedes Garayoa

Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.

Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS.

Adrenomedullin in mammalian embryogenesis.

Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis

Alternative splicing of the proadrenomedullin gene results in differential expression of gene products

Androgen-independent expression of adrenomedullin and peptidylglycine α-amidating monooxygenase in human prostatic carcinoma

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

Biological Background of Resistance to Current Standards of Care in Multiple Myeloma

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects

Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally.

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents

Downregulation of hnRNP A2/B1 expression in tumor cells under prolonged hypoxia

Effects of IL-8 Up-Regulation on Cell Survival and Osteoclastogenesis in Multiple Myeloma

Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury.

Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement.

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.

Light and electron microscopic study of the hindgut of the ant (Formica nigricans, hymenoptera): I. Structure of the ileum

Malpighian tubules of Formica polyctena (Hymenoptera): Light and electron microscopic study

Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients.

Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics

Myoendocrine-like cells in invertebrates: occurrence of noncardiac striated secretory-like myocytes in the gut of the ant Formica polyctena.

Phenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines

Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease.

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma

Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma

RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.

Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care

The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.

The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma.

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.