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List of works by Andreas Schätzlein

A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer.

scientific article published on 6 October 2014

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

scientific article published on 8 March 2007

A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine(5)-enkephalin, to the brain

scientific article published on 18 May 2012

Abstract 1129: GC-t8-linked pyrrolobenzodiazepine (PBD)-biaryl conjugates with femptomolar in vitrocytotoxicity andin vivoantitumour activity in mouse models of pancreatic and breast cancer

article published in 2013

Abstract 1780:Synthesis and antitumor activity of proximicins A, B and C

Abstract 4519: Lomustine nanoparticles are effective brain cancer treatments

article

Abstract 4799: Identification of drug resistance targets in ovarian cancer using a proteomic approach

Abstract 5527: Oral administration of a nano-enabled form of Met-Enkephalin peptide controls pancreatic cancer growth

Abstract 5530: Chitosan amphiphile nanoparticles reduced the myelosuppressive effects of lomustine: Table 1

Amphiphilic poly(L-amino acids) - new materials for drug delivery

scientific article published on 18 May 2012

Amphotericin B Formulations – The Possibility of Generic Competition

article

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles.

scientific article published on January 2004

Cancer-specific transgene expression mediated by systemic injection of nanoparticles

scientific article

Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude

scientific article published in December 2006

Chapter 7.1. Nanostructures Overcoming the Blood-Brain Barrier: Physiological Considerations and Mechanistic Issues

Chapter 7.3. Drug Delivery Strategies: Nanostructures for Improved Brain Delivery

Chitosan amphiphile coating of peptide nanofibres reduces liver uptake and delivers the peptide to the brain on intravenous administration.

scientific article published on 5 November 2014

Chitosan amphiphiles provide new drug delivery opportunities

Delivering cancer stem cell therapies - a role for nanomedicines?

scientific article

Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles.

scientific article published on 21 May 2012

Dendrimers in gene delivery

scientific article

Dextran-pegylated microparticles for enhanced cellular uptake of hydrophobic drugs

scientific article published on 16 February 2013

Direct in vivo evidence on the mechanism by which nanoparticles facilitate the absorption of a water insoluble, P-gp substrate

scientific article published on November 2016

Efficient synthesis and biological evaluation of proximicins A, B and C.

scientific article

Enhanced Oral Absorption of Hydrophobic and Hydrophilic Drugs Using Quaternary Ammonium Palmitoyl Glycol Chitosan Nanoparticles

Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor.

scientific article

Exploring uptake mechanisms of oral nanomedicines using multimodal nonlinear optical microscopy ⬇️

scholarly article by Natalie L. Garrett et al published 5 March 2012 in Journal of Biophotonics

Functional characterization of heat shock protein 90 targeted compounds

scientific article published on 04 April 2013

GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models

scientific article published on 21 March 2013

Gene and Ribonucleic Acid Therapy

article

Gene delivery with synthetic (non viral) carriers.

scientific article

Gene transfer with three amphiphilic glycol chitosans--the degree of polymerisation is the main controller of transfection efficiency.

scientific article

Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain.

scientific article published in November 2004

High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity

scientific article

High-resolution 3D isotropic MR imaging of mouse flank tumours obtained in vivo with solenoid RF micro-coil.

scientific article published on 28 December 2007

Highly Hydrophilic Fused Aggregates (Microsponges) from a C12 Spermine Bolaamphiphile

Imaging cortical vasculature with stimulated Raman scattering and two-photon photothermal lensing microscopy

article published in 2012

In silico modelling of drug-polymer interactions for pharmaceutical formulations

scientific article published on 2 June 2010

In vitro and in vivo gene transfer with poly(amino acid) vesicles.

scientific article published on December 2003

Increased Efficacy of Oral Fixed-Dose Combination of Amphotericin B and AHCC® Natural Adjuvant against Aspergillosis

scientific article published on 03 September 2019

Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule

scientific article

Limiting the level of tertiary amines on polyamines leads to biocompatible nucleic acid vectors

scientific article

Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels - A Strategy for Brain Cancer Treatments

scientific article published on 22 February 2016

Nanofiber-based delivery of therapeutic peptides to the brain

scientific article published on 10 January 2013

Nanomedicines in the treatment of brain tumors

scientific article published on 29 January 2018

Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia

scientific article published on 27 November 2017

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting.

scientific article

Non-ionic surfactant vesicle (niosome) phase transitions

Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes) ⬇️

scientific article published on April 1, 1998

Oral Particle Uptake and Organ Targeting Drives the Activity of Amphotericin B Nanoparticles

article by Dolores R Serrano et al published 15 January 2015 in Molecular Pharmaceutics

Overcoming Semipermeable Barriers, Such as the Skin, with Ultradeformable Mixed Lipid Vesicles, Transfersomes, Liposomes, or Mixed Lipid Micelles

article

PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility.

scientific article published on April 2004

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

scientific article published in October 2007

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

scientific article published on 01 June 2009

Physical Characterisation and Long-Term Stability Studies on Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ)—A New Drug Delivery Polymer

Polyamine aza-cyclic compounds demonstrate anti-proliferative activity in vitro but fail to control tumour growth in vivo

scientific article published on November 2010

Polyelectrolyte Nanoparticles with High Drug Loading Enhance the Oral Uptake of Hydrophobic Compounds

article by Woei Ping Cheng et al published May 2006 in Biomacromolecules

Polymer Based Gene Silencing: In Vitro Delivery of SiRNA.

scientific article published in January 2016

Polymeric Chitosan-based Vesicles for Drug Delivery ⬇️

scientific article published on 01 May 1998

Preferential liver gene expression with polypropylenimine dendrimers.

scientific article

Quantification of beta-galactosidase activity after non-viral transfection in vivo.

scientific article published in August 2003

Size-tuneable Nanometric MRI Contrast Agents for the Imaging of Molecular Weight Dependent Transport Processes

Solid-phase synthesis of c(RGDfK) derivatives: on-resin cyclisation and lysine functionalisation

scientific article published in February 2002

Strategies to deliver peptide drugs to the brain

scientific article published on 21 March 2014

Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors.

scientific article published on September 2005

T-shaped Peptide Amphiphiles Self Assemble into Nanofiber Networks

Targeting of Synthetic Gene Delivery Systems ⬇️

scientific article published on January 1, 2003

Targeting pancreatic cancer with a G-quadruplex ligand.

scientific article

The Encapsulation of Bleomycin Within Chitosan Based Polymeric Vesicles Does Not Alter its Biodistribution

scientific article published on 01 April 2000

The lower-generation polypropylenimine dendrimers are effective gene-transfer agents.

scientific article published on July 2002

The skin: a pathway for systemic treatment with patches and lipid-based agent carriers

Topotecan in combination with carboplatin: phase I trial evaluation of two treatment schedules.

scientific article

Transdermal drug carriers: Basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides

Transfersomes-mediated transepidermal delivery improves the regio-specificity and biological activity of corticosteroids in vivo1Dedicated to the late Dr. Henri Ernest Bodde.1

Tumour gene expression from C12 spermine amphiphile gene delivery systems

scientific article

Tumour vasculature as a target for anticancer therapy.

scientific article

Tumour-targeted drug and gene delivery: principles and concepts

scientific article published on 13 September 2004

Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements

scientific article (publication date: 19 August 2002)

Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin

scientific article

Vesicles Prepared from Synthetic Amphiphiles — Polymeric Vesicles and Niosomes

article

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