List of works by Connie Eaves

A Prospective Analysis of Human Leukemogenesis

article published in 2018

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation

scientific article

A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.

scientific article published on 11 October 2014

A fond farewell to Ernest A. McCulloch--a beacon who inspired generations of scientists and framed the foundation of modern stem cell biology

scientific article published in May 2011

A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells

scientific article published on 03 October 2019

A human embryonic stem cell line adapted for high throughput screening

scientific article published on 29 April 2013

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

scientific article

A modified polymerase chain reaction-long serial analysis of gene expression protocol identifies novel transcripts in human CD34+ bone marrow cells

scientific article

A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation

scientific article published on 17 June 2015

A topological view of human CD34 cell state trajectories from integrated single-cell output and proteomic data

scientific article published on 08 January 2019

ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status

scientific article published on 26 February 2004

Acute myeloid leukemia and the Wnt pathway

scientific article published on 01 June 2010

Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

scientific article published in 2020

Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells.

scientific article published in February 2012

Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells

scientific article published on 14 February 2008

Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy

scientific article published on 08 May 2020

Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks

scientific article published in November 2016

Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice

scientific article published on 10 January 2017

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

scientific article

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells

scientific article

BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair

scientific article published on September 2008

BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells

scientific article

Balancing work and life: an interview with Connie Eaves

scientific article published in September 2009

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.

scientific article

Basal-like Breast Cancers: From Pathology to Biology and Back Again

scientific article published on 01 June 2018

Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue

scientific article published on 6 December 2017

Cancer Stem Cells: Notes for Authors

scientific article published on 01 February 2020

Cancer stem cell definitions and terminology: the devil is in the details.

scientific article published on 11 October 2012

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

scientific article

Cancer stem cells: an evolving concept

scientific article published on 12 January 2012

Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene

scientific article

Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex

scientific article

Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation

scientific article published on 27 October 2015

Characterization of mouse hematopoietic stem and progenitor cells

scientific article published in February 2008

Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita

scientific article published on 29 February 2008

Clonal Analysis of Mouse Mammary Luminal Epithelial Cell Transplants

scientific article published on 31 January 2019

Clonal analysis of individual human embryonic stem cell differentiation patterns in microfluidic cultures.

scientific article published on 16 July 2015

Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells

scientific article published on 16 January 2014

Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells

scientific article published on 31 January 2020

Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis

scientific article published on November 2002

Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells

scientific article

Control of the hematopoietic stem cell state

scientific article published on 08 October 2013

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

scientific article

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts

scientific article

De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer

scientific article published on 22 July 2021

Deciphering the mammary epithelial cell hierarchy

scientific article published on 17 July 2006

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

scientific article (publication date: August 2002)

Developmental changes in hematopoietic stem cell properties

scientific article

Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells.

scientific article

Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics

scientific article published in December 2003

Differential effects of granulocyte colony-stimulating factor on marrow- and blood-derived hematopoietic and immune cell populations in healthy human donors

scientific article published on 01 September 2004

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

scientific article published on 4 November 2014

Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells

scientific article published on January 2017

Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation

scientific article published on 28 February 2012

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

scientific article

Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal.

scientific article

Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells

scientific article published on 4 May 2015

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

scientific article published on 26 November 2014

Early production of human neutrophils and platelets posttransplant is severely compromised by growth factor exposure.

scientific article

Editorial

Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients

scientific article published on 21 April 2005

Empirical models of the proliferative response of cytokine-dependent hematopoietic cell lines

scientific article

Engraftment of NOD/SCID-beta2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome

scientific article published on 12 February 2004

Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells

scientific article

Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors

scientific article

Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity

scientific article published in January 2005

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity

scientific article published on 27 September 2018

Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression

scientific article published on 04 June 2020

Epithelial progenitors in the normal human mammary gland

scientific article

Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia

scientific article published on 26 June 2003

Evidence of similar effects of short-term culture on the initial repopulating activity of mobilized peripheral blood transplants assessed in NOD/SCID-beta2microglobulin(null) mice and in autografted patients

scientific article published on 01 January 2005

Ex vivo expansion of human and murine hematopoietic stem cells

scientific article published in January 2002

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice

scientific article

Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells

scientific article published in August 2002

Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells

scientific article

Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia

scientific article

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

scientific article published on 30 August 2017

Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease

scientific article published in September 2002

Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.

scientific article

Functional assays for human embryonic stem cell pluripotency

scientific article published on January 2011

GateFinder: projection-based gating strategy optimization for flow and mass cytometry

scientific article published on 01 December 2018

Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY.

scientific article

Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia.

scientific article published on 11 July 2013

Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets

scientific article

Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth

scientific article published on 21 January 2014

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

scientific article published on 28 August 2016

Hematopoietic stem cell heterogeneity takes center stage

scientific article published on June 2012

Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs

scientific article published on 01 March 2012

Hematopoietic stem cells get closer to the bone

scientific article published on 01 October 2004

Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

scientific article

Hematopoietic stem cells: concepts, definitions, and the new reality.

scientific article

Here, there, everywhere?

2008 scholarly article by Connie J. Eaves

Heterogeneity in hematopoietic stem cell populations: implications for transplantation

scientific article published on July 2013

Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications.

scientific article published on 23 January 2013

Hierarchical organization of fetal and adult hematopoietic stem cells

scientific article

High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations

High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells

scientific article published on October 2004

High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal

scientific article

High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.

scientific article published on 28 July 2008

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays.

scientific article published on 22 May 2011

Human long-term culture initiating cell assay

scientific article published in January 2013

Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells

scientific article

Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties

scholarly article

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

scientific article published on October 2013

Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity

scientific article published on 01 August 2007

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

scientific article published on November 2011

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

scientific article published on June 2015

Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation

scientific article published on 26 November 2019

Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.

scientific article

Integrin β3 links therapy resistance and cancer stem cell properties.

scientific article

Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

scientific article published on 10 May 2020

Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate

scientific article published in January 2006

Introduction

scientific article published on 12 February 2019

Isolation and Assessment of Single Long-Term Reconstituting Hematopoietic Stem Cells from Adult Mouse Bone Marrow

scientific article published on 17 August 2016

Isolation and assessment of long-term reconstituting hematopoietic stem cells from adult mouse bone marrow

scientific article published on 01 November 2007

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

scientific article

Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines

scientific article

Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells

scientific article published in August 2002

Long-term culture-initiating cell assay for mouse cells

scientific article published on January 2013

Long-term culture-initiating cell assays for human and murine cells

scientific article published on 01 January 2002

Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin(-)CD34(+) cord blood cells.

scientific article published on 30 April 2013

Long-term propagation of distinct hematopoietic differentiation programs in vivo

scientific article

LongSAGE profiling of nine human embryonic stem cell lines.

scientific article published on January 2007

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

scientific article

MYC-induced human acute myeloid leukemia requires a continuing IL3/GM-CSF co-stimulus

scientific article published on 29 June 2020

Macrophages stimulate mammary stem cells

scientific article published on 01 June 2018

Manipulating hematopoietic stem cell amplification with Wnt

scientific article published on 01 June 2003

Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland

scientific article

Message from the Editor

scientific article published on 12 November 2018

Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set.

scientific article

Modeling Normal and Disordered Human Hematopoiesis

scientific article published on 2 October 2015

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13

scientific article published on 22 October 2014

Modeling human hematopoietic cell development from pluripotent stem cells

scientific article published on 14 April 2012

Modeling the process of human tumorigenesis.

scientific article

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

scientific article published on 07 April 2022

Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming

scientific article published in May 2002

Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability

scientific article

Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis

scientific article

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

scientific article published on 21 October 2012

Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions

scientific article published on May 2007

New models to investigate mechanisms of disease genesis from primitive BCR-ABL(+) hematopoietic cells

scientific article published on May 2003

Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility

scientific article published in November 2016

Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor

scientific article

Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity

scientific article published on July 2002

PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.

scientific article published in February 2018

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient

scientific article published in September 2013

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

scientific article published on 22 April 2022

Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells

scientific article

Phenotype-independent DNA methylation changes in prostate cancer

scientific article published on 15 October 2018

Phenotypic analysis of human embryonic stem cells.

scientific article published in August 2007

Plerixafor effectively mobilizes CD56bright NK cells in blood, providing an allograft predicted to protect against GVHD

scientific article published on 04 May 2018

Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo.

scientific article

Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA).

scientific article published on 09 April 2009

Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells

scientific article

Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate

scientific article

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

scientific article published on 17 April 2009

Quantitation of Human Cells that Produce Neutrophils and Platelets in Vivo Obtained from Normal Donors Treated with Granulocyte Colony-Stimulating Factor and/or Plerixafor.

scientific article published on 2 August 2016

Quantitation of human mammary epithelial stem cells with in vivo regenerative properties using a subrenal capsule xenotransplantation assay

scientific article published on 10 November 2010

Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts

scientific article published on January 2002

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

scientific article

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

scientific article

Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias

scientific article published on 2 May 2009

Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway

scientific article

Replication timing alterations in leukemia affect clinically relevant chromosome domains

scientific article published on 01 November 2019

Response to Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia"

scientific article published on 01 July 2019

Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance

scientific article

SDF-1 tells stem cells to mind their P's and Z's.

scientific article published on January 2005

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype

scientific article published on 30 May 2006

Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential

scientific article published on 25 May 2018

Single-cell analysis of autophagy activity in normal and de novo transformed human mammary cells

scientific article published on 20 November 2020

Slow receptor acquisition by NK cells regenerated in vivo from transplanted fetal liver or adult bone marrow stem cells ⬇️

scientific article published on 01 November 2003

Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.

scientific article

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia

scientific article published on 19 April 2017

Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells

scientific article

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

scientific article

Stem cell biomarkers in chronic myeloid leukemia

scientific article published on January 2008

Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges

scientific article published on 19 February 2013

Stem cells and the developing mammary gland

scientific article

Steroid hormone receptor status of mouse mammary stem cells

scientific article

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

scientific article published in February 2002

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia

scientific article published on 02 July 2019

TEL me all

scientific article published on 01 July 2009

Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice

scientific article

Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex

scientific article published on 27 February 2013

Tessa Laurie Holyoake, (March 17, 1963 – August 30, 2017): Remembering a life that knew no boundaries

scholarly article by Connie Eaves published in November 2017

The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner

scientific article

The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

scientific article published on 30 June 2013

The challenges of targeting chronic myeloid leukemia stem cells

scientific article published on March 2007

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

scientific article (publication date: 4 April 2012)

The future of mammary stem cell biology: the power of in vivo transplants

scientific article published on 29 May 2008

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

scientific article

The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny

scientific article published in May 2010

The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction.

scientific article

The marrow homing efficiency of murine hematopoietic stem cells remains constant during ontogeny ⬇️

scientific article published on April 1, 2003

The miR-185/PAK6 Axis Predicts Therapy Response and Regulates Survival of Drug-Resistant Leukemic Stem Cells in CML

scientific article published on 08 April 2020

Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

scientific article published on 01 August 2014

Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer

scientific article published on 11 January 2019

Transcriptome analysis of the normal human mammary cell commitment and differentiation process

scientific article

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

article

Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia

scientific article

Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration

scientific article published on 13 April 2006

Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia.

scientific article published on 7 June 2017

Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance

scientific article

ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

scientific article

p53: a new kingpin in the stem cell arena

scientific article

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

scientific article

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