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List of works by Christopher D. Kontos

A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits

scientific article

A comparison of antiangiogenic therapies for the prevention of liver metastases

scientific article published on 20 October 2005

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

scientific article

A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function

scientific article

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.

scientific article published on 16 October 2009

APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2

scientific article published on 14 September 2006

Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism.

scientific article

Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.

scientific article published on 29 November 2004

Allelic and locus heterogeneity in inherited venous malformations

scientific article (publication date: July 1999)

Angiopoietin-1 enhances skeletal muscle regeneration in mice.

scientific article

Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.

scientific article

Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues.

scientific article published in September 2005

Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.

scientific article

Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability.

scientific article published on 3 February 2006

Endogenous S-nitrosothiols protect against myocardial injury

scientific article

Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.

scientific article published on 30 September 2003

Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia

scientific article published on 11 October 2004

Functional significance of Tie2 signaling in the adult vasculature

scientific journal article

Gene therapy for the prevention of vein graft disease

scientific article published on 27 December 2012

H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity.

scientific article published on 19 July 2006

HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.

scientific article

High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue.

scientific article published in May 2008

IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.

scientific article

Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1

scientific article published on 06 September 2007

In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia

scientific article published in March 2007

In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide

scientific article

Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation.

scientific article published on 30 July 2013

Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer

scientific article

Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2 ⬇️

scientific article published on April 11, 2003

Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts.

scientific article published on June 2005

More than skin deep: connecting melanocyte pigmentation and angiogenic diseases.

scientific article published on 20 December 2013

Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment.

scientific article published on 19 May 2015

Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)

scientific article

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor

scientific article

PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects

scientific article published on 09 January 2002

Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.

scientific article published on December 2008

RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.

scientific article

Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density

scientific article published on 5 August 2015

Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth

scientific article published on 01 April 2007

Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization

scientific article published on 01 June 2005

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

scientific article

The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.

scientific article

Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.

scientific article published on 2 September 2008

VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

scientific article

VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.

scientific article published on 27 September 2007

p53 Functions in Endothelial Cells to Prevent Radiation-Induced Myocardial Injury in Mice ⬇️

scientific article published on July 24, 2012

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