List of works by Shanta J. Persaud

A Wake-up Call for Type 2 Diabetes?

scientific article published in September 2016

A comparative analysis of human and mouse islet G-protein coupled receptor expression

scientific article

A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion

scientific article

A myristoylated pseudosubstrate peptide inhibitor of protein kinase C: effects on glucose- and carbachol-induced insulin secretion

scientific article published on 01 August 1996

A novel Gymnema sylvestre extract protects pancreatic beta-cells from cytokine-induced apoptosis

scientific article published on 12 September 2019

A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro ⬇️

scientific article published on September 1, 2010

A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro.

scientific article

A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion

scientific article

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans

scientific article

A role for the p42/44 isoforms of MAPK in the regulation of steroid secretion from Y1 mouse adrenocortical cells.

scientific article

ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans.

scientific article published on January 2004

APT070 (mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model

scientific article

Activation of protein kinase C is essential for sustained insulin secretion in response to cholinergic stimulation

scientific article published on 01 January 1991

Activation of protein kinase C is not required for glyceraldehyde-stimulated insulin secretion from rat islets

scientific article published on 01 October 1991

Activation of protein kinase C partially alleviates noradrenaline inhibition of insulin secretion ⬇️

scientific article published on January 15, 1993

Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases

scientific article published on September 2006

Adhesion G-protein coupled receptors: Implications for metabolic function

scientific article published on 27 February 2019

All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation

scientific article published on 03 March 2016

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

scientific article

An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue

scientific article published on 19 September 2014

Analytical electron microscopy of a crack tip extracted from a stressed Alloy 800 sample exposed to an acid sulfate environment.

scientific article published on 25 February 2014

Annexin A1 Is a Key Modulator of Mesenchymal Stromal Cell-Mediated Improvements in Islet Function

scientific article published on 15 October 2015

Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta-cells.

scientific article published on January 2007

Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells

scientific article published on 22 February 2017

Antidiabetic activity of Croton klozchianus in rats and direct stimulation of insulin secretion in-vitro

scientific article published on March 2008

Antisense oligonucleotide inhibition of gene expression: application to endocrine systems.

scientific article published on April 1994

Arachidonic acid as a second messenger in glucose-induced insulin secretion from pancreatic beta-cells.

scientific article published in April 1993

Arachidonic acid induces phosphorylation of an 18 kDa protein in electrically permeabilised rat islets of Langerhans

scientific article published on 01 January 1992

Arachidonic acid-induced insulin secretion from rat islets of Langerhans is not mediated by protein phosphorylation

scientific article published on 01 February 1993

Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: incorporation of α1-antitrypsin into the coatings

scientific article

Assessing Mouse Islet Function

scientific article published on 01 January 2020

Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Gö 6976 and Ro 31-8220 as Pkc inhibitors

scientific article published on 01 October 1996

Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells

scientific article published on 4 December 2006

C3aR and C5aR1 act as key regulators of human and mouse β-cell function.

scientific article published on 18 September 2017

CXCL14 Inhibits Insulin Secretion Independently of CXCR4 or CXCR7 Receptor Activation or cAMP Inhibition

scientific article published on 01 January 2019

Ca(2+)-induced loss of Ca2+/calmodulin-dependent protein kinase II activity in pancreatic beta-cells

scientific article published on 01 April 1998

Ca2(+)-induced insulin secretion from electrically permeabilized islets. Loss of the Ca2(+)-induced secretory response is accompanied by loss of Ca2(+)-induced protein phosphorylation ⬇️

scientific article published on August 1, 1992

Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein.

scientific article published on 8 February 2011

Can we make a better beta cell?

scientific article published on 5 April 2016

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans.

scientific article published on October 2011

Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells

scientific article published on 24 August 2010

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

scientific article published on December 2016

Catecholamine inhibition of Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans

scientific article published on 01 July 1987

Cell-based treatments for diabetes

scientific article published on 04 August 2008

Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures

scientific article

Characterisation of the insulinotropic activity of an aqueous extract of Gymnema sylvestre in mouse beta-cells and human islets of Langerhans

scientific article

Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function

scientific article published on 01 April 2013

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

scientific journal article

Co-ordinated Ca(2+)-signalling within pancreatic islets: does beta-cell entrainment require a secreted messenger.

scientific article

Costus pictus extracts stimulate insulin secretion from mouse and human islets of Langerhans in vitro

scientific article published on January 2010

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

scientific article published on 17 February 2018

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

scientific article published on 08 December 2008

Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin.

scientific article

Depolarizing stimuli reduce Ca(2+)/calmodulin-dependent protein kinase II activity in islets of Langerhans

scientific article published on 01 April 2000

Diabetes mellitus: a potential target for stem cell therapy

scientific article published on May 2006

Differential expression of insulin genes 1 and 2 in MIN6 cells and pseudoislets

scientific article published on August 2002

Down-regulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration

scientific article published on May 2011

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

scientific article

E-cadherin interactions regulate beta-cell proliferation in islet-like structures

scientific article published on January 2007

Editorial overview: Endocrine and metabolic diseases Druggable diabetes: identification of therapeutic opportunities

scientific article published on 13 November 2018

Effect of 17beta-estradiol on insulin secretion and cytosolic calcium in Min6 mouse insulinoma cells and human islets of Langerhans

scientific article

Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro

scientific article published on 12 April 2007

Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets.

scientific article published on 06 May 2014

Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.

scientific article published on March 1989

Effects of a myristoylated pseudosubstrate inhibitor of PKC in intact human platelets

scientific article published on 01 May 1995

Effects of myristoylated pseudosubstrate protein kinase C peptide inhibitors on insulin secretion

scientific article published on 01 May 1995

Effects of phosphoprotein phosphatase inhibitors on steroidogenesis and StAR protein expression in Y1 cells

scientific article published on 01 August 1998

Electrical permeabilization of rat luteal cells: in situ phosphorylation of endogenous protein.

scientific article published in July 1997

Endogenous inhibitors of protein kinase C in pancreatic beta-cells.

scientific article published on May 1997

Equilibrative nucleoside transporter 3 depletion in β-cells impairs mitochondrial function and promotes apoptosis: Relationship to pigmented hypertrichotic dermatosis with insulin-dependent diabetes.

scientific article published on 9 July 2015

Expression and function of cannabinoid receptors in mouse islets

scientific article published on September 2010

Expression and function of cyclooxygenase and lipoxygenase enzymes in human islets of Langerhans

scientific article published on June 2007

Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans

scientific article

Expression and function of the extracellular calcium-sensing receptor in pancreatic beta-cells

scientific article published on June 2007

Fine tuning of insulin secretion by release of nerve growth factor from mouse and human islet β-cells

scientific article published on 13 July 2016

Function and expression of melatonin receptors on human pancreatic islets

scientific article published on 9 January 2008

Functional analysis of human islets of Langerhans maintained in culture

scientific article published in January 2012

GPR54 peptide agonists stimulate insulin secretion from murine, porcine and human islets

scientific article published on 23 December 2011

GPR55-dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans.

scientific article published on 26 August 2016

GPR55: from orphan to metabolic regulator?

scientific article published on 24 June 2014

Gene expression heterogeneity in human islet endocrine cells in vitro: the insulin signalling cascade.

scientific article published on 18 April 2007

Generation of insulin-expressing cells from mouse embryonic stem cells.

scientific article published in March 2005

Glucose-induced regulation of COX-2 expression in human islets of Langerhans

scientific article published on February 2004

Glucose-stimulated insulin secretion from rat islets of Langerhans is independent of mitogen-activated protein kinase activation

scientific article published on 01 October 1997

Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A.

scientific article published on December 1990

Gö 6976: an inhibitor of Ca2+/DAG-dependent protein kinase C isoforms in islets of Langerhans

scientific article published on 01 February 1997

Homotypic cell contact enhances insulin but not glucagon secretion

scientific article published on 19 April 2006

Human islets derived from donors after cardiac death are fully biofunctional

scientific article published on 01 October 2007

Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.

scientific article

Identifying Signalling Pathways Regulated by GPRC5B in β-Cells by CRISPR-Cas9-Mediated Genome Editing.

scientific article

Identifying novel therapeutic targets for diabetes through improved understanding of islet adhesion receptors

scientific article published on 04 August 2018

Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome.

scientific article published on 8 March 2016

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy

scientific article published on 23 September 2004

Inhibition of glucose-stimulated insulin secretion by Ro 31-8220, a protein kinase C inhibitor.

scientific article published in April 1995

Inhibition of insulin release by staurosporine and Ro 31-8220: a role for protein kinase C?

scientific article published on 01 May 1994

Insulin receptor activation inhibits insulin secretion from human islets of Langerhans

scientific article

Insulin secretion and protein phosphorylation in PKC-depleted islets of Langerhans

scientific article published on 01 January 1992

Insulin secretion from islets of GK rats is not impaired after energy generating steps

scientific article published on 01 June 1995

Insulin signalling in islets

scientific article

Interdependence of steroidogenesis and shape changes in Y1 adrenocortical cells: studies with inhibitors of phosphoprotein phosphatases.

scientific article published in March 2002

Islet G-protein coupled receptors: therapeutic potential for diabetes

scientific article published on 17 August 2017

Islet alpha-cells do not influence insulin secretion from beta-cells through cell-cell contact

scientific article published on February 2007

Islet neogenesis-associated protein signaling in neonatal pancreatic rat islets: involvement of the cholinergic pathway.

scientific article

Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta-cell mass

scientific article

Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats.

scientific article published on 17 February 2009

LH-21 and abnormal cannabidiol improve β-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling

scientific article

Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development.

scientific article

MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients.

scientific article published on 10 February 2006

Mastoparan stimulates insulin secretion from pancreatic beta-cells by effects at a late stage in the secretory pathway

scientific article published on 01 July 1993

Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation

scientific article published on 27 October 2018

Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models

scientific article

Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans

scientific article published on 01 November 1992

Nupr1 deletion protects against glucose intolerance by increasing beta cell mass

scientific article published on 31 July 2013

Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets.

scientific article published on July 1999

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

scientific article published on 29 March 2007

Pancreatic duodenal homeobox 1 expression is insufficient to transdifferentiate liver cells into insulin-secreting cells

scientific article published in March 2007

Peptide YY: more than just an appetite regulator

scientific article

Phosphoprotein phosphatase activities in rat luteal cells

scientific article published on 01 February 1995

Phosphoprotein phosphatases regulate steroidogenesis by influencing StAR gene transcription.

scientific article published on June 2000

Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction

scientific article published on 30 March 2016

Prostaglandin F2 alpha activates protein kinase C in human ovarian cells

scientific article published on 01 February 1993

Protein Kinase C Signalling in Pancreatic Beta-Cells: Cellular and Molecular Approaches ⬇️

scientific article published on January 1, 1997

Protein kinase C and the regulation of insulin secretion.

scientific article published on February 1990

Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells

scientific article published on 01 August 1998

Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK.

scientific article

Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: effects on cyclic AMP-dependent and glucose-dependent insulin secretion

scientific article published on 01 March 1997

Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70.

scientific article

Regulation of insulin secretion: the role of second messengers.

scientific article published on September 1994

Requirement of NF-kappaB signalling pathway for modulation of the cholinergic muscarinic M3 receptor expression by INGAP-PP in insulin-producing cells.

scientific article published on 10 June 2010

Retinoic Acid Induces Ubiquitination-Resistant RIP140/LSD1 Complex to Fine-Tune Pax6 Gene in Neuronal Differentiation

scientific article

Role of phosphoprotein phosphatases in the corpus luteum: I identification and characterisation of serine/threonine phosphoprotein phosphatases in isolated rat luteal cells

scientific article published on 01 August 1996

Role of phosphoprotein phosphatases in the corpus luteum: II control of progesterone secretion by isolated rat luteal cells

scientific article published on 01 August 1996

Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas

scientific article

Selective ablation of peptide YY cells in adult mice reveals their role in beta cell survival.

scientific article published on 2 May 2012

Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2

scientific article published on 03 October 2018

Signaling through the p38 and p42/44 mitogen-activated families of protein kinases in pancreatic beta-cell proliferation.

scientific article

Similarities of K+ATP channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons

scientific article

Single-cell RT-PCR identification of genes expressed by human islet endocrine cells.

scientific article

Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

scientific article

Staurosporine inhibits protein kinases activated by Ca2+ and cyclic AMP in addition to inhibiting protein kinase C in rat islets of Langerhans

scientific article published on 01 July 1993

Stem cell therapy for diabetes: do we need to make beta cells?

scientific article published on 01 December 2004

Stem cells and the endocrine pancreas

scientific article published on 03 June 2011

Synchronization of Ca(2+)-signals within insulin-secreting pseudoislets: effects of gap-junctional uncouplers.

scientific article

The Association Between Selective Serotonin Reuptake Inhibitors and Glycemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

scientific article published on 01 September 2019

The Placental Secretome: Identifying Potential Cross-Talk Between Placenta and Islet β-Cells

scientific article published on 8 February 2018

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

scientific article published on 31 May 2018

The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice.

scientific article

The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling

scientific article published on 10 January 2020

The development of new density gradient media for purifying human islets and islet-quality assessments

scientific article

The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro

scientific article published on 20 October 2016

The extracellular calcium-sensing receptor in PHHI beta cells: does reduced auto-inhibitory input contribute to hypersecretion of insulin?

scientific article published on 01 August 2000

The in vitro differentiation of rat neural stem cells into an insulin-expressing phenotype

scientific article published in January 2005

The inhibition of stimulus-secretion coupling in pancreatic islets by volatile anaesthetics does not involve pertussis toxin sensitive G-proteins.

scientific article published in May 1994

The involvement of protein kinase C in glucose-stimulated insulin secretion

scientific article published on 01 November 1993

The mitogen-activated protein kinase cascade in rat islets of Langerhans

scientific article published on 01 May 1995

The mitogen-activated protein kinase pathway in rat islets of Langerhans: studies on the regulation of insulin secretion

scientific article

The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells.

scientific article published on 21 December 2017

The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis

scientific article

The permissive effects of glucose on receptor-operated potentiation of insulin secretion from mouse islets: a role for ERK1/2 activation and cytoskeletal remodelling.

scientific article published on 24 January 2013

The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans

scientific article

The role of cytosolic phospholipase A(2) in insulin secretion

scientific article published in February 2004

The role of protein kinase C in insulin biosynthesis.

scientific article

Time-course of Ca2+-induced insulin secretion from perifused, electrically permeabilised islets of Langerhans: effects of cAMP and a phorbol ester

scientific article published on 01 August 1989

Translocation of protein kinase C in rat islets of Langerhans. Effects of a phorbol ester, carbachol and glucose

scientific article published on 01 March 1989

Tyrosine kinase inhibitors inhibit glucose-stimulated insulin secretion

scientific article published on 01 May 1994

Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets.

scientific article published on February 1999

Uncoupling of nutrient metabolism from insulin secretion by overexpression of cytosolic phospholipase A(2).

scientific article

Paulina is supported by:

About Paulina

Help