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List of works by Junyan Lu

A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2).

scientific article published on 22 January 2016

A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation

scientific article

A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1.

scientific article published on 2 March 2013

Application of Epigenome‐Modifying Small Molecules in Induced Pluripotent Stem Cells ⬇️

scientific article published on May 11, 2012

Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.

scientific article

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness

scientific article published on 06 August 2021

Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study

scientific article

Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction

scientific article

Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia

scientific article published on 10 July 2019

Drug-perturbation-based stratification of blood cancer

scientific article published on 11 December 2017

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

scientific article published on 21 February 2019

FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels

scientific article

Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease ⬇️

scientific article published on April 26, 2013

IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics

scientific article published on 19 November 2020

Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling

scientific article published in 2022

Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.

scientific article

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

scientific article

Investigation of the Acetylation Mechanism by GCN5 Histone Acetyltransferase ⬇️

scientific article published on May 4, 2012

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

scientific article published on 18 April 2019

Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging

scientific article

Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia

scientific article published on 01 July 2021

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

scientific article

Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer

scientific article published on 01 June 2020

Structural insight into substrate preference for TET-mediated oxidation

scientific article

Structure-based computational study of the hydrolysis of New Delhi metallo-β-lactmase-1.

scientific article

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma

scientific article published on 13 April 2018

Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling

scientific article published on 08 August 2019

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

scientific article published on 02 November 2020

Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1

scientific article (publication date: 2013)

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA ⬇️

scientific article published on February 12, 2012

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