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List of works by Rosemary O'Connor

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

scientific article published on 27 June 2019

A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.

scientific article published on 2 October 2009

A cell viability assay based on monitoring respiration by optical oxygen sensing

scientific article published on 01 February 2000

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

scientific article

Comparative bioenergetic assessment of transformed cells using a cell energy budget platform

scientific article published on 17 October 2011

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

scientific journal article

Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription

scientific article published on 8 November 2011

Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.

scientific article

EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.

scientific article published in January 2004

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).

scientific article published in May 2002

Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.

scientific article

FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion

scientific article published on 15 March 2018

Fluorescence-based cell viability screening assays using water-soluble oxygen probes

scientific article

HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.

scientific article published on 21 October 2013

Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

scientific article published on 29 October 2009

IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

scientific article

IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway

scientific article published on 08 January 2020

IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251

scientific article published on 26 May 2020

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

scientific article published on 27 July 2016

Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells.

scientific article

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

scientific article

Induction of apoptosis by the Bcl-2 homologue Bak

scientific article

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.

scientific article published on 18 August 2017

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

scientific article

Interleukin 4 inhibits IL-2-induced proliferation of a human T-leukemia cell line without interfering with p56-LCK kinase activation

scientific article published on September 1992

Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation.

scientific article published on 18 August 2017

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.

scientific article published on 12 May 2008

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

scientific article

Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells

scientific article

Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth

scientific article

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer

scientific article published on 18 March 2019

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.

scientific article published on 15 April 2013

PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.

scientific article

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

scientific article

Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction.

scientific article published on 28 June 2011

Production and characterization of a monoclonal antibody to a myeloid specific differentiation antigen

scientific article published in January 1987

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.

scientific article published on 19 September 2013

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

scientific article published on 3 September 2016

RACK1 to the future--a historical perspective

scientific article

Regulation of IGF-I receptor signaling in tumor cells.

scientific article published on November 2003

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

scientific article

Rethinking the bile acid/gut microbiome axis in cancer

scientific article published in December 2017

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

scientific article published on 14 April 2010

Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB.

scientific article

Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth

scientific article

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1

scientific article

Survival factors and apoptosis ⬇️

scientific article published on 01 January 1998

The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis

scientific article published on 01 April 2000

The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth

scientific article

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway ⬇️

scientific article published on April 5, 2011

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

scientific article

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