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List of works by Vigneshwaran Namasivayam

2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2

scientific article published on 20 August 2018

3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17

scientific article published on 05 September 2018

6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).

scientific article published on 20 March 2018

A2B Adenosine Receptor Antagonists with Picomolar Potency

scientific article published on 15 April 2019

Agonists and Antagonists for Purinergic Receptors

scientific article published on 01 January 2020

An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights

scientific article published on 27 November 2019

An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.

scientific article published on 15 February 2016

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors

scientific article published on 16 March 2021

Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress

scientific article published on 18 April 2022

Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

scientific article published on 11 February 2020

Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies

scientific article

Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

scientific article published on 29 April 2020

Design and synthesis of sulfonamidophenylethylamides as novel cardiac myosin activator

scientific article published on 27 July 2019

Design, Synthesis, and Characterization of Some Hybridized Pyrazolone Pharmacophore Analogs against Mycobacterium tuberculosis.

scientific article

Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor.

scientific article

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)

article

Exploring SAR continuity in the vicinity of activity cliffs

scientific article published on 8 November 2011

Feature-Based Molecular Networking for the Targeted Identification of G<sub>q</sub>-Inhibiting FR900359 Derivatives

scientific article published in July 2021

Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry

scientific article published on 22 April 2018

HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: SAR and lead optimization using CoMFA and CoMSIA studies (1995-2016).

scientific article

Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach

scientific article published on 30 April 2019

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

scientific article published on 31 March 2023

Inhibitors of Melanogenesis: An Updated Review

scientific article published on 24 May 2018

Interaction of Approved Drugs with Synaptic Vesicle Protein 2A.

scientific article

Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies

scientific article published on 05 December 2019

Macrocyclic Hepatitis C Virus NS3/4A Protease Inhibitors: An Overview of Medicinal Chemistry

scientific article published on 10 May 2016

Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor.

scientific article

Multiobjective Particle Swarm Optimization: Automated Identification of Structure–Activity Relationship-Informative Compounds with Favorable Physicochemical Property Distributions ⬇️

scientific article published on October 18, 2012

Overview of Recent Strategic Advances in Medicinal Chemistry

scientific article published on 28 May 2019

Probing the binding mechanism of mercaptoguanine derivatives as inhibitors of HPPK by docking and molecular dynamics simulations.

scientific article published on 15 November 2016

Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor

scientific article published on 29 July 2018

Role of extracellular cysteine residues in the adenosine A2A receptor.

scientific article published on 11 March 2016

Searching for Coordinated Activity Cliffs Using Particle Swarm Optimization ⬇️

scientific article published on March 29, 2012

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.

scientific article published on December 2017

Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors

scientific article published on 21 March 2019

Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists

scientific article published on 15 November 2019

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

scientific article published on 15 February 2017

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

scientific article published on 27 December 2018

The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.

scientific article published on 20 December 2016

Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359

scientific article published on 08 January 2021

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

scientific article published in 2020

pso@autodock: a fast flexible molecular docking program based on Swarm intelligence

scientific article published on 6 November 2007

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