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List of works by James L. Hougland

A fluorescent peptide substrate facilitates investigation of ghrelin recognition and acylation by ghrelin O-acyltransferase

scientific article published on 27 February 2013

A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups

scientific article published on 15 May 2015

An atomic mutation cycle for exploring RNA's 2'-hydroxyl group

scientific article published on 01 October 2004

An overview of ghrelin O-acyltransferase inhibitors: a literature and patent review for 2010-2019

scientific article published on 21 June 2020

Biochemical Assays for Ghrelin Acylation and Inhibition of Ghrelin O-Acyltransferase

scientific article published on 01 January 2019

Context-dependent substrate recognition by protein farnesyltransferase.

scientific article published on March 2009

Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.

scientific article

Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.

scientific article

Functional group and stereochemical requirements for substrate binding by ghrelin O-acyltransferase revealed by unnatural amino acid incorporation

scientific article published on 21 April 2018

Getting a handle on protein prenylation

scientific article published in April 2009

Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates

scientific article published on 13 September 2016

Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity

scientific article published on 19 October 2019

Ghrelin octanoylation by ghrelin O-acyltransferase: Unique protein biochemistry underlying metabolic signaling

scientific article published on 09 January 2019

Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity

scientific article

Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities

scientific article

Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite.

scientific article

Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

scientific article published on 10 March 2020

Protein Isoprenylation in Yeast Targets COOH-Terminal Sequences Not Adhering to the CaaX Consensus

scientific article published on 26 September 2018

Quantitative determination of cellular farnesyltransferase activity: towards defining the minimum substrate reactivity for biologically relevant protein farnesylation.

scientific article published on 2 September 2014

Simultaneous Analysis of a Non-Lipidated Protein and Its Lipidated Counterpart: Enabling Quantitative Investigation of Protein Lipidation's Impact on Cellular Regulation.

scientific article published on 16 November 2017

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases.

scientific article published on 12 November 2015

Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition.

scientific article

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates

scientific article

Synthesis of frame-shifted farnesyl diphosphate analogs

scientific article published on 02 August 2012

Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation

scientific article

Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition.

scientific article published on 6 January 2014

The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.

scientific article published on 24 June 2008

The ghrelin O-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation

scientific article published on 14 August 2019

The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin's biological interactions and avenues for controlling ghrelin signaling.

scientific article published on 16 November 2017

Using selective withdrawal to coat microparticles

scientific article

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