List of works - János Wölfling

A click approach to novel D-ring-substituted 16α-triazolylestrone derivatives and characterization of their antiproliferative properties

scientific article

A facile access to novel steroidal 17-2'-(1',3',4')-oxadiazoles, and an evaluation of their cytotoxic activities in vitro.

scientific article published on 31 January 2014

A molecular understanding of D-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells

scientific article

Addition reactions at the 16(17) double bond of 3-methoxy-13alpha-estra-1,3,5(10),16-tetraene

scientific article published in March 2003

An approach to the synthesis and attachment of scillabiose to steroids

scientific article

An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.

scientific article published on 22 October 2013

Analysis of nonderivatized steroids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using C70 fullerene as matrix

scientific article published on 15 August 2009

Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate

scientific article published on 17 February 2014

Antiproliferative effect of normal and 13-epi-D-homoestrone and their 3-methyl ethers on human reproductive cancer cell lines

scientific article

Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

scientific article

Aromatic Sulfonamides Containing a Condensed Piperidine Moiety as Potential Oxidative Stress-Inducing Anticancer Agents ⬇️

scientific article published on November 1, 2013

CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells.

scientific article published on May 2013

Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1.

scientific article published on 18 July 2016

Computer-aided structure analysis of an epimerized dehydroepiandrosterone derivative and its biological effect in a model of reactive gliosis

scientific article published on 11 January 2010

Corrigendum to "Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities" [Steroids 105 (2016) 113-120].

scientific article

Cycloaddition of steroidal cyclic nitrones to C=N dipolarophiles: stereoselective synthesis and antiproliferative effects of oxadiazolidinones in the estrone series

scientific article

Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

scientific article

Dehydroepiandrosterone sulfate is neuroprotective when administered either before or after injury in a focal cortical cold lesion model

scientific article

Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

scientific journal article

Efficient Synthesis of a Novel Estrone- Talaromycin Hybrid Natural Product

scientific article published on 01 October 1998

Efficient access to novel androsteno-17-(1',3',4')-oxadiazoles and 17β-(1',3',4')-thiadiazoles via N-substituted hydrazone and N,N'-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro.

scientific article published on 7 May 2015

Efficient approach to androstene-fused arylpyrazolines as potent antiproliferative agents. Experimental and theoretical studies of substituent effects on BF(3)-catalyzed intramolecular [3 + 2] cycloadditions of olefinic phenylhydrazones.

scientific article published in March 2009

Efficient approach to novel 1α-triazolyl-5α-androstane derivatives as potent antiproliferative agents

scientific article published on 6 October 2011

Electrophile-induced generation of cyclic azomethine imines from steroidal delta-alkenyl hydrazones

scientific article published on 13 January 2009

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

scientific article

High-performance liquid chromatographic methods for monitoring of isomers of 17-hydroxy-16-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene

scientific article published on 01 August 1999

In vitro binding of 16-methylated C18 and C19 steroid derivatives to the androgen receptor

scientific article published on 01 October 1995

In vitro inhibitory effects of 16-methyl-substituted steroids on 5 alpha-reductase in rat and human prostates

scientific article published on 01 October 1994

Increasing the amphiphilicity of an estradiol based steroid structure by Barbier-allylation--ring-closing metathesis--dihydroxylation sequence

scientific article

Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro.

scientific article published on 9 August 2017

Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2 H-Azirines via Joullié-Ugi Three-Component Reaction

scientific article

Lewis acid-induced intramolecular access to novel steroidal ring D-condensed arylpyrazolines exerting in vitro cell-growth-inhibitory effects.

scientific article

Mechanism of antiproliferative action of a new d-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility

scientific article published on 27 June 2016

Microwave-Assisted Stereoselective Heterocyclization to Novel Ring d-fused Arylpyrazolines in the Estrone Series

Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro

scientific article published on 3 May 2016

Multicomponent access to androstano-arylpyrimidines under microwave conditions and evaluation of their anti-cancer activity in vitro.

scientific article

Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17alpha-hydroxylase-C(17,20)-lyase

scientific article published on 5 July 2008

Neighboring group participation. Part 14. The preparation of the four stereoisomers of 16-hydroxymethyl-5alpha-androstane-3beta,17-diol.

scientific article

Neighboring group participation. Part 15. Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones, as novel presumed inhibitors of human 5alpha-reductase

scientific article published in July 2004

Neighboring group participation. Part 16. Stereoselective synthesis and receptor-binding examination of the four stereoisomers of 16-bromomethyl-3,17-estradiols

scientific article

Novel 13β- and 13α-D-homo steroids: 17a-carboxamido-D-homoestra-1,3,5(10),17-tetraene derivatives via palladium-catalyzed aminocarbonylations

scientific article published on 13 July 2010

Novel series of 17β-pyrazolylandrosta-5,16-diene derivatives and their inhibitory effect on 17α-hydroxylase/C(17,20)-lyase

scientific article published on 15 July 2012

One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

scientific article published on 08 March 2018

Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines

scientific article published on 10 June 2014

Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities

scientific article published on 11 December 2015

Stereoselective halogenation of the 16-hydroxymethyl-3-methoxy-13alpha-estra-1,3,5(10)-trien-17-ols and their solvolytic investigation

scientific article

Stereoselective synthesis of some 17beta-dihydrooxazinyl steroids, as novel presumed inhibitors of 17alpha-hydroxylase-C17,20-lyase

scientific article published on 30 June 2006

Stereoselective synthesis of spiro and condensed pyrazolines of steroidal alpha,beta-unsaturated ketones and nitrilimines by 1,3-dipolar cycloaddition.

scientific article published on 13 February 2009

Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities

scientific article published in March 2018

Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17alpha-hydroxylase-C17,20-lyase

scientific article published on 8 August 2009

Syntheses and antiproliferative effects of D-homo- and D-secoestrones

scientific article

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates.

scientific article published on 10 September 2016

Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents

scientific article published on 2 June 2016

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative.

scientific article published on 12 May 2016

Synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives.

scientific article published on 9 June 2011

Synthesis and in vitro antiproliferative evaluation of d-secooxime derivatives of 13β- and 13α-estrone

scientific article published on 20 August 2014

Synthesis and in vitro investigation of potential antiproliferative monosaccharide-d-secoestrone bioconjugates

scientific article

Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds

scientific article published on 11 September 2015

Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro.

scientific article

Synthesis and receptor-binding examination of 16-hydroxymethyl-3,17-estradiol stereoisomers

scientific article published in April 2002

Synthesis and receptor-binding examination of 16-hydroxymethyl-3,17-estradiol stereoisomers

scientific article published in June 2002

Synthesis and receptor-binding examinations of the normal and 13-epi-D-homoestrones and their 3-methyl ethers

scientific article published in March 2003

Synthesis and stereochemical investigations of novel nitrogen-containing 13alpha-estrone derivatives

scientific article published on 18 April 2006

Synthesis and structure-activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

scholarly article by Ildikó Bacsa et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

Synthesis of A-ring halogenated 13α-estrone derivatives as potential 17β-HSD1 inhibitors

scientific article published on 22 October 2015

Synthesis of D-ring-substituted (5'R)- and (5'S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities

scientific article

Synthesis of antiproliferative 13α-d-homoestrones via Lewis acid-promoted one-pot Prins-Ritter reactions of d-secosteroidal δ-alkenyl-aldehydes

scientific article published on 22 July 2015

Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation

scientific article published on 21 March 2015

Synthesis of new 16-spirosteroids

scientific article published on 01 May 1994

Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

scientific article published on 30 June 2017

Synthesis of novel 17-(4'-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17α-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents depending on the substitution pattern of the heteroring.

scientific article

Synthesis of novel 17-(5'-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro.

scientific article

Synthesis of novel 17-triazolyl-androst-5-en-3-ol epimers via Cu(I)-catalyzed azide-alkyne cycloaddition and their inhibitory effect on 17α-hydroxylase/C17,20-lyase

scientific article published on 22 March 2018

Synthesis of novel steroid-tetrahydroquinoline hybrid molecules and D-homosteroids by intramolecular cyclization reactions

scientific article

Synthesis of novel steroidal 16-spiroisoxazolines by 1,3-dipolar cycloaddition, and an evaluation of their antiproliferative activities in vitro

scientific article published on 2 April 2014

Synthesis of novel steroidal 17α-triazolyl derivatives via Cu(I)-catalyzed azide-alkyne cycloaddition, and an evaluation of their cytotoxic activity in vitro

scientific article published on 10 May 2011

Synthesis of regioisomeric 17beta-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17alpha-hydroxylase/C(17,20)-lyase

scientific article published on 3 March 2010

Synthesis of trans-16-triazolyl-13α-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities

scientific article

Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series.

scientific article published on 18 May 2012

Synthesis, functionalization and biological activity of arylated derivatives of (+)-estrone

scientific article published on 9 December 2016

The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series.

scientific article

The synthesis of 13alpha-androsta-5,16-diene derivatives with carboxylic acid, ester and carboxamido functionalities at position-17 via palladium-catalyzed carbonylation

scientific article published on 30 December 2008

The synthesis of 17-alkoxycarbonyl- and 17-carboxamido-13alpha-estra-1,3,5(10),16-tetraene derivatives via palladium-catalyzed carbonylation reactions

scientific article published on 16 February 2008

List of works by János Wölfling

A click approach to novel D-ring-substituted 16α-triazolylestrone derivatives and characterization of their antiproliferative properties

A facile access to novel steroidal 17-2'-(1',3',4')-oxadiazoles, and an evaluation of their cytotoxic activities in vitro.

A molecular understanding of D-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells

Addition reactions at the 16(17) double bond of 3-methoxy-13alpha-estra-1,3,5(10),16-tetraene

An approach to the synthesis and attachment of scillabiose to steroids

An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.

Analysis of nonderivatized steroids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using C70 fullerene as matrix

Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate

Antiproliferative effect of normal and 13-epi-D-homoestrone and their 3-methyl ethers on human reproductive cancer cell lines

Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

Aromatic Sulfonamides Containing a Condensed Piperidine Moiety as Potential Oxidative Stress-Inducing Anticancer Agents ⬇️

CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells.

Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1.

Computer-aided structure analysis of an epimerized dehydroepiandrosterone derivative and its biological effect in a model of reactive gliosis

Corrigendum to "Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities" [Steroids 105 (2016) 113-120].

Cycloaddition of steroidal cyclic nitrones to C=N dipolarophiles: stereoselective synthesis and antiproliferative effects of oxadiazolidinones in the estrone series

Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

Dehydroepiandrosterone sulfate is neuroprotective when administered either before or after injury in a focal cortical cold lesion model

Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

Efficient Synthesis of a Novel Estrone- Talaromycin Hybrid Natural Product

Efficient access to novel androsteno-17-(1',3',4')-oxadiazoles and 17β-(1',3',4')-thiadiazoles via N-substituted hydrazone and N,N'-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro.

Efficient approach to androstene-fused arylpyrazolines as potent antiproliferative agents. Experimental and theoretical studies of substituent effects on BF(3)-catalyzed intramolecular [3 + 2] cycloadditions of olefinic phenylhydrazones.

Efficient approach to novel 1α-triazolyl-5α-androstane derivatives as potent antiproliferative agents

Electrophile-induced generation of cyclic azomethine imines from steroidal delta-alkenyl hydrazones

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

High-performance liquid chromatographic methods for monitoring of isomers of 17-hydroxy-16-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene

In vitro binding of 16-methylated C18 and C19 steroid derivatives to the androgen receptor

In vitro inhibitory effects of 16-methyl-substituted steroids on 5 alpha-reductase in rat and human prostates

Increasing the amphiphilicity of an estradiol based steroid structure by Barbier-allylation--ring-closing metathesis--dihydroxylation sequence

Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro.

Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2 H-Azirines via Joullié-Ugi Three-Component Reaction

Lewis acid-induced intramolecular access to novel steroidal ring D-condensed arylpyrazolines exerting in vitro cell-growth-inhibitory effects.

Mechanism of antiproliferative action of a new d-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility

Microwave-Assisted Stereoselective Heterocyclization to Novel Ring d-fused Arylpyrazolines in the Estrone Series

Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro

Multicomponent access to androstano-arylpyrimidines under microwave conditions and evaluation of their anti-cancer activity in vitro.

Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17alpha-hydroxylase-C(17,20)-lyase

Neighboring group participation. Part 14. The preparation of the four stereoisomers of 16-hydroxymethyl-5alpha-androstane-3beta,17-diol.

Neighboring group participation. Part 15. Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones, as novel presumed inhibitors of human 5alpha-reductase

Neighboring group participation. Part 16. Stereoselective synthesis and receptor-binding examination of the four stereoisomers of 16-bromomethyl-3,17-estradiols

Novel 13β- and 13α-D-homo steroids: 17a-carboxamido-D-homoestra-1,3,5(10),17-tetraene derivatives via palladium-catalyzed aminocarbonylations

Novel series of 17β-pyrazolylandrosta-5,16-diene derivatives and their inhibitory effect on 17α-hydroxylase/C(17,20)-lyase

One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines

Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities

Stereoselective halogenation of the 16-hydroxymethyl-3-methoxy-13alpha-estra-1,3,5(10)-trien-17-ols and their solvolytic investigation

Stereoselective synthesis of some 17beta-dihydrooxazinyl steroids, as novel presumed inhibitors of 17alpha-hydroxylase-C17,20-lyase

Stereoselective synthesis of spiro and condensed pyrazolines of steroidal alpha,beta-unsaturated ketones and nitrilimines by 1,3-dipolar cycloaddition.

Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities

Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17alpha-hydroxylase-C17,20-lyase

Syntheses and antiproliferative effects of D-homo- and D-secoestrones

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates.

Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative.

Synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives.

Synthesis and in vitro antiproliferative evaluation of d-secooxime derivatives of 13β- and 13α-estrone

Synthesis and in vitro investigation of potential antiproliferative monosaccharide-d-secoestrone bioconjugates

Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds

Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro.

Synthesis and receptor-binding examination of 16-hydroxymethyl-3,17-estradiol stereoisomers

Synthesis and receptor-binding examination of 16-hydroxymethyl-3,17-estradiol stereoisomers

Synthesis and receptor-binding examinations of the normal and 13-epi-D-homoestrones and their 3-methyl ethers

Synthesis and stereochemical investigations of novel nitrogen-containing 13alpha-estrone derivatives

Synthesis and structure-activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

Synthesis of A-ring halogenated 13α-estrone derivatives as potential 17β-HSD1 inhibitors

Synthesis of D-ring-substituted (5'R)- and (5'S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities

Synthesis of antiproliferative 13α-d-homoestrones via Lewis acid-promoted one-pot Prins-Ritter reactions of d-secosteroidal δ-alkenyl-aldehydes

Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation

Synthesis of new 16-spirosteroids

Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

Synthesis of novel 17-(4'-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17α-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents depending on the substitution pattern of the heteroring.

Synthesis of novel 17-(5'-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro.

Synthesis of novel 17-triazolyl-androst-5-en-3-ol epimers via Cu(I)-catalyzed azide-alkyne cycloaddition and their inhibitory effect on 17α-hydroxylase/C17,20-lyase

Synthesis of novel steroid-tetrahydroquinoline hybrid molecules and D-homosteroids by intramolecular cyclization reactions

Synthesis of novel steroidal 16-spiroisoxazolines by 1,3-dipolar cycloaddition, and an evaluation of their antiproliferative activities in vitro

Synthesis of novel steroidal 17α-triazolyl derivatives via Cu(I)-catalyzed azide-alkyne cycloaddition, and an evaluation of their cytotoxic activity in vitro

Synthesis of regioisomeric 17beta-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17alpha-hydroxylase/C(17,20)-lyase

Synthesis of trans-16-triazolyl-13α-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities

Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series.