List of works - Naoki Harada

17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α

scientific journal article

5-Hydroxy-7-methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

scientific article published on 20 November 2018

A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor

scientific article published on 07 September 2010

Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells.

scientific article

Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic β-Cells

scientific article

Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.

scientific article published on 14 November 2017

Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia.

scientific article published on 14 July 2015

Biochemical characterization of a GH53 endo-β-1,4-galactanase and a GH35 exo-β-1,4-galactanase from Penicillium chrysogenum

scientific article published on 16 May 2012

Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.

scientific article

Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells.

scientific article published on 19 August 2008

Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice

scientific article published on 12 August 2017

Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56

scientific article published on 27 October 2019

Female-specific regulation of skeletal muscle mass by USP19 in young mice

scientific article

Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats

scientific article published on 09 July 2019

Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup

scientific article published on 29 May 2020

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death.

scientific article published on 06 February 2017

Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease

scientific article published on 10 September 2015

Glyceraldehyde-3-phosphate dehydrogenase in the extracellular space inhibits cell spreading.

scientific article published on 10 August 2005

Hypogonadism alters cecal and fecal microbiota in male mice

scientific article published on 22 September 2016

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment

scientific article

Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

scientific article published in 2022

Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene

scientific article published on January 2013

Inhibitory effects of eucalyptus and banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats

scientific article published on 27 April 2015

Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor.

scientific article published on 10 November 2010

Involvement of three glutamine tracts in human androgen receptor transactivation.

scientific article published on 13 October 2009

Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.

scientific article published on 24 August 2011

Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts

scientific article published on 18 August 2017

Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy

scientific article published on 13 February 2018

Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

scientific article

Oleamide rescues tibialis anterior muscle atrophy of mice housed in small cages

scientific article published on 04 November 2020

Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells.

scientific article

Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders

scientific article published on 01 November 2020

Resveratrol down-regulates the androgen receptor at the post-translational level in prostate cancer cells.

scientific article published on December 2007

Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells

scientific article published on January 2014

Role of androgens in energy metabolism affecting on body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity: lessons from a meta-analysis and rodent studies

scientific article published on 29 June 2018

Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice

scientific article published on 04 February 2020

S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice

scientific article published on 2 August 2017

Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation

scientific article published on 28 February 2018

The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy

scientific article

The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice

scientific article published on 09 October 2012

Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes

scientific article published on 3 April 2018

Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes

scientific article published on 10 September 2019

Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells ⬇️

scientific article published on February 19, 2011

pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells

scientific article published on 21 June 2016

β-Carotene Increases Muscle Mass and Hypertrophy in the Soleus Muscle in Mice

scientific article published in January 2015

List of works by Naoki Harada

17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α

5-Hydroxy-7-methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor

Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells.

Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic β-Cells

Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.

Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia.

Biochemical characterization of a GH53 endo-β-1,4-galactanase and a GH35 exo-β-1,4-galactanase from Penicillium chrysogenum

Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.

Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells.

Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice

Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56

Female-specific regulation of skeletal muscle mass by USP19 in young mice

Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats

Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death.

Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease

Glyceraldehyde-3-phosphate dehydrogenase in the extracellular space inhibits cell spreading.

Hypogonadism alters cecal and fecal microbiota in male mice

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment

Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene

Inhibitory effects of eucalyptus and banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats

Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor.

Involvement of three glutamine tracts in human androgen receptor transactivation.

Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.

Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts

Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy

Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

Oleamide rescues tibialis anterior muscle atrophy of mice housed in small cages

Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells.

Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders

Resveratrol down-regulates the androgen receptor at the post-translational level in prostate cancer cells.

Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells

Role of androgens in energy metabolism affecting on body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity: lessons from a meta-analysis and rodent studies

Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice

S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice

Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation

The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy

The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice

Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes

Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes

Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells ⬇️

pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells

β-Carotene Increases Muscle Mass and Hypertrophy in the Soleus Muscle in Mice