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List of works by Rachel C. Chambers

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis

scientific article published on 18 March 2019

Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis

scientific journal article

Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.

scientific article published on 23 March 2009

Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter

scientific journal article

Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation.

scientific article published on 10 December 2004

Acute Respiratory Distress Syndrome

scientific article published on 01 August 2017

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

scientific article published on 27 August 2014

Angiotensin II and the fibroproliferative response to acute lung injury.

scientific article

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

scientific article published on 11 September 2020

BARD1 mediates TGF-β signaling in pulmonary fibrosis.

scientific article

Bleomycin revisited: towards a more representative model of IPF?

scientific article published on 30 July 2010

Cadmium inhibits proteoglycan and procollagen production by cultured human lung fibroblasts

scientific article published in September 1998

Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae ⬇️

scientific article

Coagulation Cascade Proteinases in Lung Injury and Fibrosis

scientific article published on July 1, 2012

Coagulation and coagulation signalling in fibrosis.

scientific article published on 05 January 2013

Coagulation signalling following tissue injury: focus on the role of factor Xa.

scientific article published on 07 March 2008

Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch.

scientific article published on 7 April 2006

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

scientific article published on 21 January 2019

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

scientific article

Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis

scientific article

Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.

scientific article

Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis

scientific article published in April 2008

Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease

scientific article published on 30 September 2013

Evidence for chemokine synergy during neutrophil migration in ARDS

scientific article published on 05 August 2016

Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation

scientific article published on 21 March 2013

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

scientific article published on 21 April 2016

Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome

scientific article published on 7 September 2017

Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

scientific article

From clot to collagen: coagulation peptides in interstitial lung disease ⬇️

scientific article published on May 1, 1998

Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq

scientific article published on 16 May 2018

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

scientific article published on February 2003

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

scientific article published on 19 June 2024

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

scientific article published on 01 March 2016

Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations

scientific article

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

scientific article published on 01 May 1998

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

scientific article published on 03 August 2009

Innate Immunity in Lung Fibrosis: A Therapeutic Role for Surfactant Protein D? ⬇️

scientific article published on 01 March 2012

Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis

scientific article published in November 2016

International registry for idiopathic pulmonary fibrosis

article published in 2008

Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis

scientific article published on July 2014

JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk

scientific article published on 06 July 2020

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

scientific article

Mechanisms of alveolar epithelial injury, repair, and fibrosis

scientific article

Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.

scientific article

Molecular targets in pulmonary fibrosis: the myofibroblast in focus.

scientific article published on October 2007

Neutrophils and tissue damage: is hypoxia the key to excessive degranulation?

scientific article published in September 2016

New tale for an old fox in IPF?

scientific article published on 11 January 2013

Novel therapeutic approaches for pulmonary fibrosis

scientific article

PAR-1-dependent and PAR-independent pro-inflammatory signaling in human lung fibroblasts exposed to thrombin.

scientific article published in November 2012

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

scientific article published on 7 July 2008

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages

scientific article published on 27 January 2014

Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation

scientific article published on January 2014

Proteinase-activated receptors in fibroproliferative lung disease.

scientific article

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis

scientific article

Pulmonary venous hypertension and mechanical strain stimulate monocyte chemoattractant protein-1 release and structural remodelling of the lung in human and rodent chronic heart failure models

scientific article published on 15 September 2014

Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection ⬇️

scientific article

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

scientific article published in 2023

Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

scientific article published on 17 August 2015

Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants

scientific article

Role of thrombin in pulmonary fibrosis

scientific article published on 01 October 1995

Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury.

scientific article published on January 2007

Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.

scientific article published on 5 January 2016

Synthesis of novel and potent vorapaxar analogues

scientific article published in March 2016

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

scientific article

Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis

scientific article published on 01 September 2020

The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

scientific article published on 28 September 2022

The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

scientific article

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

scientific article published in Nature Communications

The mercurial nature of neutrophils: still an enigma in ARDS?

scientific article published on 06 December 2013

The pathogenesis of pulmonary fibrosis: a moving target

scientific article published on 25 October 2012

The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis

scientific article published on 01 September 2020

The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats.

scientific article published in June 2002

Thrombin

scientific article published on 01 June 1998

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways

scientific article published on 19 March 2008

Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

scientific article published on November 2000

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

scientific article published on 19 November 2020

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

scientific article published on 16 September 2020

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis

scientific article published on 21 May 2019

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