List of works - Michael Butler

A low redox potential affects monoclonal antibody assembly and glycosylation in cell culture.

scientific article published on 10 February 2017

A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions.

scientific article published on 11 March 2017

A systematic study of glycopeptide esterification for the semi-quantitative determination of sialylation in antibodies

scientific article published on October 2015

Adaptation of mammalian cells to non-ammoniagenic media.

scientific article published on January 1994

An integrated approach to analyze EG2-hFc monoclonal antibody N-glycosylation by MALDI-MS

scientific article published in July 2015

Application of a serum-free medium for the growth of Vero cells and the production of reovirus

scientific article published on 01 September 2000

Application of the StrOligo algorithm for the automated structure assignment of complex N-linked glycans from glycoproteins using tandem mass spectrometry.

scientific article

CHO cells adapted to hypothermic growth produce high yields of recombinant beta-interferon.

scientific article published in July 2008

Characterization of glutamine metabolism in two related murine hybridomas

scientific article published on April 1992

Components of yeast (Sacchromyces cervisiae) extract as defined media additives that support the growth and productivity of CHO cells.

scientific article published on 7 May 2016

Detailed glycan analysis of serum glycoproteins of patients with congenital disorders of glycosylation indicates the specific defective glycan processing step and provides an insight into pathogenesis

scientific article

Development of an assay for the measurement of the surfactant pluronic F-68 in mammalian cell culture medium

scientific article published on 01 August 1998

Dielectric model for Chinese hamster ovary cells obtained by dielectrophoresis cytometry.

scientific article

Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans

scientific article

Differential electronic detector to monitor apoptosis using dielectrophoresis-induced translation of flowing cells (dielectrophoresis cytometry).

scientific article

Dissolved oxygen concentration in serum-free continuous culture affects N-linked glycosylation of a monoclonal antibody.

scientific article

Effect of ammonia on the glycosylation of human recombinant erythropoietin in culture

scientific article published on 01 September 2000

Effect of temperature on nucleotide pools and monoclonal antibody production in a mouse hybridoma.

scientific article

Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

scientific article published in January 2002

Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody.

scientific article published on 8 July 2014

Enhanced erythropoietin heterogeneity in a CHO culture is caused by proteolytic degradation and can be eliminated by a high glutamine level

scientific article published on October 2000

Enhanced production of human recombinant proteins from CHO cells grown to high densities in macroporous microcarriers.

scientific article published in November 2011

Enhanced production of monomeric interferon-beta by CHO cells through the control of culture conditions.

scientific article

Erratum to: Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids.

scientific article published on 9 November 2015

Evaluation of Quenching and Extraction Methods for Nucleotide/Nucleotide Sugar Analysis

scientific article

Expression systems for therapeutic glycoprotein production.

scientific article

Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production.

scientific article

Fragmentation of negative ions from N-linked carbohydrates, part 4. Fragmentation of complex glycans lacking substitution on the 6-antenna.

scientific article published in May 2010

Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture

scientific article published on November 1993

Glutamine-based dipeptides are utilized in mammalian cell culture by extracellular hydrolysis catalyzed by a specific peptidase

scientific article published on November 1994

Glycan-masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development

article

Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: the effect of culture mode and the anti-apoptotic gene, bcl-2.

scientific article published on May 2007

Growth inhibition in animal cell culture. The effect of lactate and ammonia

scientific article published on July 1991

Growth, cytopathogenicity and morphology of Mycoplasma gallisepticum and M. gallinarum in tracheal explants

scientific article published on 01 July 1976

High Genetic Stability of Dengue Virus Propagated in MRC-5 Cells as Compared to the Virus Propagated in Vero Cells

scientific article

High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture

scientific article published on 2 August 2006

High productivity of human recombinant beta-interferon from a low-temperature perfusion culture.

scientific article published on 8 October 2010

High yields of monomeric recombinant beta-interferon from macroporous microcarrier cultures under hypothermic conditions.

scientific article published in July 2008

Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells

scientific article

Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro.

scientific article

Inhibition of glutamine-dependent autophagy increases t-PA production in CHO cell fed-batch processes.

scientific article published on 21 December 2011

Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity.

scientific article

Isolation and Growth of Mycoplasma in Human Embryo Trachea Cultures

scientific article published in Nature

Linoleic acid improves the robustness of cells in agitated cultures

scientific article published on July 1999

Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture.

scientific article published on 24 June 2015

MDCK microcarrier cultured: seeding density effects and amino acid utilization

scientific article published on 01 March 1982

Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids.

scientific article published on 11 September 2015

Measurement of hydrophobic interactions of mammalian cells grown in culture

scientific article published on April 2002

Microwave frequency sensor for detection of biological cells in microfluidic channels

scientific article

Monitoring cell growth, viability, and apoptosis.

scientific article

Monitoring the dielectric response of single cells following mitochondrial adenosine triphosphate synthase inhibition by oligomycin using a dielectrophoretic cytometer.

scientific article published on November 2014

Natural incidence and persistence of complement-fixing antibody to two equine mycoplasmas ⬇️

scientific article published on 01 January 1976

Pluronic enhances the robustness and reduces the cell attachment of mammalian cells.

scientific article published in June 2008

Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography

scientific article

Production and glycosylation of recombinant beta-interferon in suspension and cytopore microcarrier cultures of CHO cells

scientific article published in January 2005

Production of α2,6-sialylated IgG1 in CHO cells

scientific article

Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization

scientific article published on 01 October 1994

Progression of change in membrane capacitance and cytoplasm conductivity of cells during controlled starvation using dual-frequency DEP cytometry

scientific article published on 03 February 2019

Purification of chimeric heavy chain monoclonal antibody EG2-hFc using hydrophobic interaction membrane chromatography: an alternative to protein-A affinity chromatography.

scientific article

Quantitative Model for Ion Transport and Cytoplasm Conductivity of Chinese Hamster Ovary Cells

scientific article published in Scientific Reports

Recent advances in technology supporting biopharmaceutical production from mammalian cells

scientific article published on 05 October 2012

Recombinant hemagglutinin proteins formulated in a novel PELC/CpG adjuvant for H7N9 subunit vaccine development.

scientific article published on 22 September 2017

Single cell dielectrophoresis study of apoptosis progression induced by controlled starvation

Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies

scientific article published on 16 December 2017

Specific activities of glycosyltransferase enzymes vary with monoclonal antibody productivity in murine hybridomas

scientific article published on 02 November 2004

The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody.

scientific article published on 25 November 2013

The bioactivity and fractionation of peptide hydrolysates in cultures of CHO cells.

scientific article published on 28 May 2014

The changing dielectric properties of CHO cells can be used to determine early apoptotic events in a bioprocess.

scientific article published on 3 July 2013

The choice of mammalian cell host and possibilities for glycosylation engineering.

scientific article published on 05 July 2014

The development of complement-fixing antibody in horses after infection with Mycoplasma equirhinis

scientific article published on 01 April 1977

The effect of alternative carbohydrates on the growth and antibody production of a murine hybridoma

scientific article published on 01 April 1996

The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture

scientific article published on 01 April 1997

The effect of dissolved oxygen on the production and the glycosylation profile of recombinant human erythropoietin produced from CHO cells.

scientific article published in June 2006

The effect of fatty acids on hybridoma cell growth and antibody productivity in serum-free cultures

scientific article published on 01 April 1995

The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma.

scientific article

The effect of pH on the toxicity of ammonia to a murine hybridoma

scientific article published on 01 July 1990

The effect of the catalytic topoisomerase II inhibitor dexrazoxane (ICRF-187) on CC9C10 hybridoma viability and productivity

scientific article published on October 2001

The inhibitory effect of glutamate on the growth of a murine hybridoma is caused by competitive inhibition of the x(-) (C) transport system required for cystine utilization.

scientific article published on January 2000

The relationship between intracellular UDP-N-acetyl hexosamine nucleotide pool and monoclonal antibody production in a mouse hybridoma.

scientific article published on February 1998

Tuning a MAb glycan profile in cell culture: Supplementing N-acetylglucosamine to favour G0 glycans without compromising productivity and cell growth.

scientific article published on 17 September 2015

Using recombinant DNA technology for the development of live-attenuated dengue vaccines.

scientific article published on 17 May 2012

List of works by Michael Butler

A low redox potential affects monoclonal antibody assembly and glycosylation in cell culture.

A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions.

A systematic study of glycopeptide esterification for the semi-quantitative determination of sialylation in antibodies

Adaptation of mammalian cells to non-ammoniagenic media.

An integrated approach to analyze EG2-hFc monoclonal antibody N-glycosylation by MALDI-MS

Application of a serum-free medium for the growth of Vero cells and the production of reovirus

Application of the StrOligo algorithm for the automated structure assignment of complex N-linked glycans from glycoproteins using tandem mass spectrometry.

CHO cells adapted to hypothermic growth produce high yields of recombinant beta-interferon.

Characterization of glutamine metabolism in two related murine hybridomas

Components of yeast (Sacchromyces cervisiae) extract as defined media additives that support the growth and productivity of CHO cells.

Detailed glycan analysis of serum glycoproteins of patients with congenital disorders of glycosylation indicates the specific defective glycan processing step and provides an insight into pathogenesis

Development of an assay for the measurement of the surfactant pluronic F-68 in mammalian cell culture medium

Dielectric model for Chinese hamster ovary cells obtained by dielectrophoresis cytometry.

Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans

Differential electronic detector to monitor apoptosis using dielectrophoresis-induced translation of flowing cells (dielectrophoresis cytometry).

Dissolved oxygen concentration in serum-free continuous culture affects N-linked glycosylation of a monoclonal antibody.

Effect of ammonia on the glycosylation of human recombinant erythropoietin in culture

Effect of temperature on nucleotide pools and monoclonal antibody production in a mouse hybridoma.

Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody.

Enhanced erythropoietin heterogeneity in a CHO culture is caused by proteolytic degradation and can be eliminated by a high glutamine level

Enhanced production of human recombinant proteins from CHO cells grown to high densities in macroporous microcarriers.

Enhanced production of monomeric interferon-beta by CHO cells through the control of culture conditions.

Erratum to: Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids.

Evaluation of Quenching and Extraction Methods for Nucleotide/Nucleotide Sugar Analysis

Expression systems for therapeutic glycoprotein production.

Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production.

Fragmentation of negative ions from N-linked carbohydrates, part 4. Fragmentation of complex glycans lacking substitution on the 6-antenna.

Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture

Glutamine-based dipeptides are utilized in mammalian cell culture by extracellular hydrolysis catalyzed by a specific peptidase

Glycan-masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development

Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: the effect of culture mode and the anti-apoptotic gene, bcl-2.

Growth inhibition in animal cell culture. The effect of lactate and ammonia

Growth, cytopathogenicity and morphology of Mycoplasma gallisepticum and M. gallinarum in tracheal explants

High Genetic Stability of Dengue Virus Propagated in MRC-5 Cells as Compared to the Virus Propagated in Vero Cells

High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture

High productivity of human recombinant beta-interferon from a low-temperature perfusion culture.

High yields of monomeric recombinant beta-interferon from macroporous microcarrier cultures under hypothermic conditions.

Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells

Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro.

Inhibition of glutamine-dependent autophagy increases t-PA production in CHO cell fed-batch processes.

Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity.

Isolation and Growth of Mycoplasma in Human Embryo Trachea Cultures

Linoleic acid improves the robustness of cells in agitated cultures

Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture.

MDCK microcarrier cultured: seeding density effects and amino acid utilization

Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids.

Measurement of hydrophobic interactions of mammalian cells grown in culture

Microwave frequency sensor for detection of biological cells in microfluidic channels

Monitoring cell growth, viability, and apoptosis.

Monitoring the dielectric response of single cells following mitochondrial adenosine triphosphate synthase inhibition by oligomycin using a dielectrophoretic cytometer.

Natural incidence and persistence of complement-fixing antibody to two equine mycoplasmas ⬇️

Pluronic enhances the robustness and reduces the cell attachment of mammalian cells.

Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography

Production and glycosylation of recombinant beta-interferon in suspension and cytopore microcarrier cultures of CHO cells

Production of α2,6-sialylated IgG1 in CHO cells

Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization

Progression of change in membrane capacitance and cytoplasm conductivity of cells during controlled starvation using dual-frequency DEP cytometry

Purification of chimeric heavy chain monoclonal antibody EG2-hFc using hydrophobic interaction membrane chromatography: an alternative to protein-A affinity chromatography.

Quantitative Model for Ion Transport and Cytoplasm Conductivity of Chinese Hamster Ovary Cells

Recent advances in technology supporting biopharmaceutical production from mammalian cells

Recombinant hemagglutinin proteins formulated in a novel PELC/CpG adjuvant for H7N9 subunit vaccine development.

Single cell dielectrophoresis study of apoptosis progression induced by controlled starvation

Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies

Specific activities of glycosyltransferase enzymes vary with monoclonal antibody productivity in murine hybridomas

The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody.

The bioactivity and fractionation of peptide hydrolysates in cultures of CHO cells.

The changing dielectric properties of CHO cells can be used to determine early apoptotic events in a bioprocess.

The choice of mammalian cell host and possibilities for glycosylation engineering.

The development of complement-fixing antibody in horses after infection with Mycoplasma equirhinis

The effect of alternative carbohydrates on the growth and antibody production of a murine hybridoma

The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture

The effect of dissolved oxygen on the production and the glycosylation profile of recombinant human erythropoietin produced from CHO cells.

The effect of fatty acids on hybridoma cell growth and antibody productivity in serum-free cultures

The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma.

The effect of pH on the toxicity of ammonia to a murine hybridoma

The effect of the catalytic topoisomerase II inhibitor dexrazoxane (ICRF-187) on CC9C10 hybridoma viability and productivity

The inhibitory effect of glutamate on the growth of a murine hybridoma is caused by competitive inhibition of the x(-) (C) transport system required for cystine utilization.

The relationship between intracellular UDP-N-acetyl hexosamine nucleotide pool and monoclonal antibody production in a mouse hybridoma.