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List of works by Ali A Ashkar

A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection.

scientific article published on 22 February 2011

A preliminary study on the usefulness of huil-8 in cervical relaxation of the ewe for artificial insemination and for embryo transfer

scientific article published in July 1999

AHR signaling is induced by infection with coronaviruses

scientific article published on 26 August 2021

Acute toxicity of benzene inhalation to hemopoietic precursor cells

scientific article published in April 1977

Adaptive immune responses fail to provide protection against genital HSV-2 infection in the absence of IL-15

scientific article published in September 2007

Analysis of the effects of microbiome-related confounding factors on the reproducibility of the volatolomic test.

scientific article

Assessment of Requirements for IL-15 and IFN Regulatory Factors in Uterine NK Cell Differentiation and Function During Pregnancy

scientific article published on 5 September 2003

CD4+ T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice

scientific article published in January 2011

Characterization and IL-15 dependence of NK cells in humanized mice

scientific article published in January 2011

Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production.

scientific article published on 18 October 2008

Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells.

scientific article published on 21 June 2017

Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection

scientific article published on 01 September 2007

Critical role of natural killer cells in lung immunopathology during influenza infection in mice.

scientific article published on 4 May 2012

Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand.

scientific article

Decidual natural killer cells: key regulators of placental development (a review).

scientific article

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

scientific article

Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge

scientific article

Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women.

scientific article published on 12 November 2008

Effective control of viral infections by the adaptive immune system requires assistance from innate immunity.

scientific article

Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner

scientific article published in July 2011

Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

scientific article published on 20 May 2017

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

scientific article published on 03 October 2016

Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells

scientific article published on 21 September 2017

Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours

scientific article

Ex vivo-expanded NK cells from blood and ascites of ovarian cancer patients are cytotoxic against autologous primary ovarian cancer cells.

scientific article

Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs.

scientific article

Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity.

scientific article

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling

scientific article

FimH can directly activate human and murine natural killer cells via TLR4

scientific article

FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice.

scientific article

Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice

scientific article published on 10 November 2017

Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy.

scientific article

Genital HSV-2 infection induces short-term NK cell memory

scientific article

HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium

scientific article published on 16 September 2013

Herpes simplex virus-2 in the genital mucosa: insights into the mucosal host response and vaccine development

scientific article published on February 2012

Herpesviruses and the innate immune response.

scientific article

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy

article

Humanized mice are susceptible to Salmonella typhi infection ⬇️

scientific article published on November 8, 2010

Humanized mice for Salmonella typhi infection: new tools for an old problem.

scientific article published on May 2011

Hypertension in the Elderly

scientific article published in September 2005

Hypertension management in the high cardiovascular risk population.

scientific article published on 6 February 2013

IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity

scientific article published on 15 October 2019

IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells

scientific article published on 9 February 2011

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells

scientific article published on 23 March 2012

IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation.

scientific article published on 20 June 2017

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

scientific article published on 12 July 2021

Immunity to ocular and genital herpes simplex viruses infections

scientific article published on 26 December 2012

Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge.

scientific article published on 17 June 2016

Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.

scientific article published on 30 November 2007

Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production.

scientific article

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

scientific article published on 6 March 2017

Influenza Infection Leads to Increased Susceptibility to Subsequent Bacterial Superinfection by Impairing NK Cell Responses in the Lung

article

Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa.

scientific article published on 21 February 2011

Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy

scientific article published in July 2000

Interferon-gamma alters the phagocytic activity of the mouse trophoblast

scientific article

Interferon-γ Contributes to the Normalcy of Murine Pregnancy1

scientific article published in August 1999

Interleukin-15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes

scientific article published on 17 December 2009

Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection.

scientific article

Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-gamma.

scientific article published on 9 April 2009

Interleukin-15 is required for maximal lipopolysaccharide-induced abortion

scientific article published on 15 March 2013

Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.

scientific article

Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice

scientific article published on 30 October 2011

Interleukin-15 treatment induces weight loss independent of lymphocytes.

scientific article

Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2.

scientific article

M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.

scientific article published on 4 August 2016

Major depression and external stressors: the Lebanon Wars

scientific article published on 28 October 1998

Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice

scientific article published on 23 October 2019

Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model

scientific article published on 05 August 2009

NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung.

scientific article published in April 2008

NK cells require antigen-specific memory CD4+ T cells to mediate superior effector functions during HSV-2 recall responses in vitro

scientific article published on 14 December 2016

NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection

scientific article published on 12 March 2011

Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

scientific article

Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells.

scientific article

Outbreak of tetanus in lambs

scientific article published on 9 May 1998

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.

scientific article published on 16 April 2015

Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2

scientific article

Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge

scientific article published on 6 October 2003

Progesterone increases susceptibility and decreases immune responses to genital herpes infection

scientific article

Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells.

scientific article published on 30 October 2013

Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice ⬇️

scientific article

Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.

scientific article published on 23 February 2012

Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection

scientific article published on 4 April 2014

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

scientific article

Stimulating natural killer cells to protect against cancer: recent developments.

scientific article published on May 2011

Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection.

scientific article published on 19 September 2007

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes

scientific article published on 30 April 2014

TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut

scientific article published on 05 April 2019

The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages

scientific article published on 29 October 2014

The Application of Humanized Mouse Models for the Study of Human Exclusive Viruses.

scientific article published on January 2017

The breast tumor microenvironment alters the phenotype and function of natural killer cells

scientific article published on 17 August 2015

The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity

scientific article published in June 2006

The influence of macrophages and the tumor microenvironment on natural killer cells.

scientific article published on January 2013

The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts

scientific article

The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection.

scientific article published on January 2008

Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films

scientific article published on 21 May 2019

Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA.

scientific article

Toll-like receptors, natural killer cells and innate immunity.

scientific article published on January 2007

Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity

scientific article published on 5 March 2015

Type I interferon regulation of natural killer cell function in primary and secondary infections.

scientific article published on August 2013

Type I interferon signalling is not required for the induction of endotoxin tolerance

scientific article published on 8 February 2017

Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus

scientific article

Vaginal transmission causes prolonged Zika virus shedding in the vaginal mucosa and delays systemic dissemination

scientific article published in 2022

Vitamin D3 modulates the function of chicken macrophages.

scientific article

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