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List of works by David Carling

140 Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues ⬇️

scientific article published on 01 November 1997

5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms

scientific article published on 01 November 1995

5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes

scientific article published in April 2012

5'-AMP-activated protein kinase-activating transcription factor 1 cascade modulates human monocyte-derived macrophages to atheroprotective functions in response to heme or metformin

scientific article published on 19 September 2013

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

scientific article published on 01 November 1987

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

scientific article published on 2 April 2007

A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice

scientific article

A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling

scientific article published on 01 December 2020

ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase

scientific article

AMP-activated kinase regulates cytoplasmic HuR.

scientific article

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

scientific article

AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes

scientific article

AMP-activated protein kinase plays a role in the control of food intake

scientific article (publication date: 26 March 2004)

AMP-activated protein kinase: also regulated by ADP?

scientific article published on 23 July 2011

AMP-activated protein kinase: balancing the scales.

scientific article

AMP-activated protein kinase: nature's energy sensor

scientific article published on 18 July 2011

AMP-activated protein kinase: new regulation, new roles? ⬇️

scientific article published on July 1, 2012

AMP-activated protein kinase: the current landscape for drug development

scientific article published on 01 July 2019

AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue

scientific article published on 25 February 2019

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

scientific article

AMPK hierarchy: a matter of space and time

scientific article published on 01 June 2019

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

scientific article

AMPK signalling in health and disease.

scientific article published on 20 February 2017

AMPK, insulin resistance, and the metabolic syndrome

scientific article published on July 2013

AMPK.

scientific article published in March 2004

Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK.

scientific article

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase

scientific article

Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart

scientific journal article

Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase

scientific article published on 01 December 2000

Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.

scientific article published in January 1991

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

scientific article

Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

scientific article

Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism

scientific article published on June 2015

Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses

scientific article published on 01 October 2007

Branching out on AMPK Regulation

scientific article published on 01 January 2009

CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.

scientific article published on 21 September 2018

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

scientific article published on 9 April 2006

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

scientific article

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

scientific article published on 12 July 2021

Cellular energy sensor balances the scales

scientific article

Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity

scientific article published on 01 May 1994

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

scientific article

Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase

scientific article

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

scientific article published on 9 December 2005

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

scientific article

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

scientific article published on 26 April 2016

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

scientific article published on 29 August 2007

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice

scientific article

Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: a cautionary tale

scientific article published on 6 March 2009

Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets

scientific article published on 01 February 1992

Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.

scientific article published on March 1998

Effect of different γ-subunit isoforms on the regulation of AMPK

scientific article

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

scientific article published in Nature

Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components

scientific article

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity

scientific article published in April 2005

Fluorescence lifetime readouts of Troponin-C-based calcium FRET sensors: a quantitative comparison of CFP and mTFP1 as donor fluorophores.

scientific article

Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.

scientific article published on 22 October 2002

Glucokinase activity in the arcuate nucleus regulates glucose intake

scientific article

Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation

scientific article published in January 2002

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

scientific article

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

scientific article published in May 2008

Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle ⬇️

scientific article published on May 15, 1998

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

scientific article published on 21 May 2003

Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM.

scientific article published on 19 August 2016

Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function

scientific article

Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma

scientific article published on 16 March 2022

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

scientific article

Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation

scientific article

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

scientific article published on 25 September 2018

Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction

scientific article published in September 2002

LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis

scientific article (publication date: 2011)

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

scientific article published on February 2011

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

scientific journal article

LKB1: a sweet side to Peutz-Jeghers syndrome?

scientific article

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

scientific article (publication date: 17 January 2002)

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

scientific article published on March 2017

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

scientific article

Low utilization of circulating glucose after food withdrawal in Snell dwarf mice

scientific article published on 28 September 2007

Mammalian γ2 AMPK regulates intrinsic heart rate

scientific article

Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise

article

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

scientific article published in Journal of Biological Chemistry

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

scientific article published on 28 September 2021

Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism.

scientific article published on November 1997

Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase

scientific article (publication date: 12 December 1994)

Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression.

scientific article

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.

scientific article published on 14 June 2016

Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases

scientific article published on 01 August 1988

Neuregulin signaling on glucose transport in muscle cells

scientific journal article

Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase.

scientific article published in January 2007

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

scientific article

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

scientific article published on 10 July 2017

Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism

scientific article published on 01 January 1989

Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation ⬇️

scientific article published on June 17, 2013

Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495

scientific article published on 01 September 2020

Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside.

scientific article published in November 2002

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

scientific article published in July 1994

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

scientific article published on 9 April 2015

Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress.

scientific article

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase

scientific article published in June 2007

Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK

scientific article published on 30 November 2020

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

scientific article

Structural basis for AMP binding to mammalian AMP-activated protein kinase

scientific article

Structural basis of AMPK regulation by small molecule activators

scientific article

Structure of mammalian AMPK and its regulation by ADP

scientific article

Taking the stress out of melanoma

scientific article published on March 2009

The AMP-activated protein kinase cascade--a unifying system for energy control

scientific article (publication date: 2004)

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

article by Benoit Viollet et al published 1 January 2003 in Journal of Clinical Investigation

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

scientific article (publication date: 1998)

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

scientific article

The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1

scientific article published on 01 June 1999

The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

scientific journal article

The mammalian AMP-activated protein kinase complex mediates glucose regulation of gene expression in the yeast Saccharomyces cerevisiae

article

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.

scientific article published on 19 May 2016

The regulation and function of mammalian AMPK-related kinases.

scientific article published on 19 February 2009

The regulation of AMP-activated protein kinase by phosphorylation

scientific article

The regulation of AMP-activated protein kinase by upstream kinases.

scientific article published on September 2008

The role of ATM in response to metformin treatment and activation of AMPK

scientific article published on 28 March 2012

The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis

scientific article published on 01 June 1986

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

scientific article

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

scientific article published on 01 June 1989

Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta

scientific article

Time-lapse 3-D measurements of a glucose biosensor in multicellular spheroids by light sheet fluorescence microscopy in commercial 96-well plates

scientific article

Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.

scientific article

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

scientific article published on 01 December 2006

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