List of works - Peter Vangheluwe

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span

scientific article published on 30 June 2006

A lipid switch unlocks Parkinson's disease-associated ATP13A2

scientific journal article

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

scientific article published on 30 January 2017

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

scientific article published on 23 November 2020

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.

scientific article published on 22 February 2017

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

scientific article published on 11 December 2020

An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1

scientific article published on 28 March 2019

An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells.

scientific article

Ca2+ induces spontaneous dephosphorylation of a novel P5A-type ATPase.

scientific article

Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart.

scientific article published in December 2003

Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only

scientific article published on 27 March 2003

Cardiomyocyte Overexpression of Neuronal Nitric Oxide Synthase Delays Transition Toward Heart Failure in Response to Pressure Overload by Preserving Calcium Cycling

scientific article published on 09 June 2008

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

scientific article

DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store

scientific article

Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness.

scientific article published on 14 August 2007

Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps.

scientific article published in July 2012

Factors controlling the activity of the SERCA2a pump in the normal and failing heart.

scientific article

High-throughput measurement of the Ca2+-dependent ATPase activity in COS microsomes

scientific article published on 01 August 2014

Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.

scientific article published on 20 January 2006

Measuring Ca2+ pump activity in overexpression systems and cardiac muscle preparations

scientific article published on 01 August 2014

Measuring Ca2+-dependent Ca2+-uptake activity in the mouse heart

scientific article published on 01 August 2014

Modeling Ca2+ dynamics of mouse cardiac cells points to a critical role of SERCA's affinity for Ca2+.

scientific article published on March 2011

Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications.

scientific article

New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.

scientific article published on 25 August 2006

Parkinson disease related ATP13A2 evolved early in animal evolution.

scientific article published on 5 March 2018

Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signaling

scientific article published on 13 April 2012

Polyamine Transport Assay Using Reconstituted Yeast Membranes

publication published on 20 January 2021

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2.

scientific article

Regulation of endoplasmic reticulum Ca(2+) oscillations in mammalian eggs

scientific article

SPCA2 couples Ca2+ influx via Orai1 to Ca2+ uptake into the Golgi/secretory pathway

scientific article published on 17 September 2016

Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.

scientific article published on July 2005

Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump.

scientific article published on 21 October 2009

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).

scientific article published on 6 March 2017

Structures of the heart specific SERCA2a Ca2+-ATPase

scientific article published on 18 February 2019

Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss.

scientific article published in February 2010

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases

scientific article published on 4 January 2011

The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy

scientific article published on 5 June 2015

The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.

scientific article published on May 2011

The endoplasmic reticulum Ca2+ -ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis

scientific article published on 26 October 2020

The expression of the neonatal sarcoplasmic reticulum Ca2+ pump (SERCA1b) hints to a role in muscle growth and development.

scientific article published on 28 September 2006

Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level

scientific article published on 15 February 2007

Time-Dependent Protein Thermostability Assay.

scientific article published in January 2016

Towards defining the substrate of orphan P5A-ATPases

scientific article published on 14 May 2014

Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of β-subunit on α-Na+,K+-ATPase.

scientific article

Unlocking ATP13A2/PARK9 activity

scientific journal article

List of works by Peter Vangheluwe

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span

A lipid switch unlocks Parkinson's disease-associated ATP13A2

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system

An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1

An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells.

Ca2+ induces spontaneous dephosphorylation of a novel P5A-type ATPase.

Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart.

Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only

Cardiomyocyte Overexpression of Neuronal Nitric Oxide Synthase Delays Transition Toward Heart Failure in Response to Pressure Overload by Preserving Calcium Cycling

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store

Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness.

Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps.

Factors controlling the activity of the SERCA2a pump in the normal and failing heart.

High-throughput measurement of the Ca2+-dependent ATPase activity in COS microsomes

Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.

Measuring Ca2+ pump activity in overexpression systems and cardiac muscle preparations

Measuring Ca2+-dependent Ca2+-uptake activity in the mouse heart

Modeling Ca2+ dynamics of mouse cardiac cells points to a critical role of SERCA's affinity for Ca2+.

Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications.

New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.

Parkinson disease related ATP13A2 evolved early in animal evolution.

Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signaling

Polyamine Transport Assay Using Reconstituted Yeast Membranes

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2.

Regulation of endoplasmic reticulum Ca(2+) oscillations in mammalian eggs

SPCA2 couples Ca2+ influx via Orai1 to Ca2+ uptake into the Golgi/secretory pathway

Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.

Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump.

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).

Structures of the heart specific SERCA2a Ca2+-ATPase

Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss.

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases

The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy

The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.

The endoplasmic reticulum Ca2+ -ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis

The expression of the neonatal sarcoplasmic reticulum Ca2+ pump (SERCA1b) hints to a role in muscle growth and development.

Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level

Time-Dependent Protein Thermostability Assay.

Towards defining the substrate of orphan P5A-ATPases

Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of β-subunit on α-Na+,K+-ATPase.

Unlocking ATP13A2/PARK9 activity