List of works by Wendy Keung

A Heart-Breast Cancer-on-a-Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

scientific article published on 23 October 2020

A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells.

scientific article published on 22 April 2014

AAV-mediated conversion of human pluripotent stem cell-derived pacemaker.

scientific article published on 6 October 2017

Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.

scientific article published on 14 May 2015

Activating PPARα prevents post-ischemic contractile dysfunction in hypertrophied neonatal hearts

scientific article published on 14 May 2015

Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts

scientific article published on 29 May 2007

An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients.

scientific article published on 25 July 2017

Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers.

scientific article published on 12 September 2016

Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

scientific article published on 10 February 2018

Cardiac hypertrophy in the newborn delays the maturation of fatty acid β-oxidation and compromises postischemic functional recovery

scientific article published on 09 March 2012

Chronic central leptin decreases food intake and improves glucose tolerance in diet-induced obese mice independent of hypothalamic malonyl CoA levels and skeletal muscle insulin sensitivity.

scientific article published on 13 September 2011

Circulating sex hormones modulate vascular contractions and acute response to 17β-estradiol in rat mesenteric arteries

scientific article published on 25 July 2011

Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes.

scientific article published on 28 January 2014

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.

scientific article published on 13 May 2013

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias.

scientific article

Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.

scientific article published on 28 July 2017

Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies

scientific article

Electrophysiological mechanisms of long and short QT syndromes.

scientific article

Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell-derived ventricular cardiomyocytes: insights for driven maturation and hypertrophic growth.

scientific article published on 14 June 2013

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.

scientific article

Genistein potentiates protein kinase A activity in porcine coronary artery.

scientific article published on 30 December 2007

Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts.

scientific article

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

scientific article published on 17 February 2018

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

scientific article published on 4 June 2013

Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.

scientific article published on 8 November 2012

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

scientific article published on 3 June 2010

Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance

scientific article published on 16 October 2012

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

scientific article published on 22 May 2012

Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet

scientific article published on 01 January 2011

Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts.

scientific article published on 23 July 2010

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.

scientific article published on 12 October 2017

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a

scientific article published on 20 April 2011

Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.

scientific article

Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cells.

scientific article

Mouse models of atherosclerosis: a historical perspective and recent advances.

scientific article

Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels.

scientific article published on 28 September 2016

Non-genomic activation of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery.

scientific article

Polycystin-2 Plays an Essential Role in Glucose Starvation-Induced Autophagy in Human Embryonic Stem Cell-Derived Cardiomyocytes.

scientific article published on 22 December 2017

Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers

scientific article published on 21 May 2018

Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation

scientific article

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

scientific article published on 21 March 2012

Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes

scientific article published on 01 April 2019

TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes

scientific article published on 16 May 2018

Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).

scientific article published on 06 February 2017

Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.

scientific article published on 20 January 2011

Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation

scientific article

Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK

scientific article published in July 2008

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice

scientific article

Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice

scientific article published on 29 April 2014

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