List of works - Fabio Benedetti

1-Arylsulfonylamino-1,2,3-triazole derivatives from functionalyzed 1,2-cyclohexanediones

1-Substituted morpholino ethenes—III

A Potent HIV Protease Inhibitor Identified in an Epimeric Mixture by High-Resolution Protein Crystallography

article

A catalytic antibody programmed for torsional activation of amide bond hydrolysis

scientific article published in July 2003

A competitive immunoassay for the detection of esterolytic activity of antibodies and enzymes.

scientific article

A study of the molecular structure and spectroscopic properties of polycyclic polyaza-compounds with diamond-lattice conformations

article

Addressing the Poly- to Oligo-ketone Selectivity in Styrene Carbonylation Catalyzed by Palladium/bpy Complexes. Effect of the 6-Alkyl Substitution

Albumin-controlled stereoselective reduction of 1,3-diketones to anti-diolsElectronic supplementary information (ESI) available: Scatchard and Lineweaver–Burk plots. See http://www.rsc.org/suppdata/cc/b2/b200474g/

scientific article published on 01 April 2002

Albumin-directed stereoselective reduction of 1,3-diketones and β-hydroxyketones to anti diols

scientific article published on 24 January 2011

Aldolase activity of serum albumins.

scientific article published on 11 May 2011

An Unprecedented Catalytic Motif Revealed in the Model Structure of Amide Hydrolyzing Antibody 312d6

article

An albumin-derived peptide scaffold capable of binding and catalysis

scientific article

An enzyme‐linked immunosorbent assay for the direct analysis of beta‐agonist drugs in urine and sera

Antibody catalyzed modification of amino acids. Efficient hydrolysis of tyrosine benzoate

Aspartic protease inhibitors

scientific article published in 2000

Chiral Pincer Ruthenium and Osmium Complexes for the Fast and Efficient Hydrogen Transfer Reduction of Ketones

scholarly article by Walter Baratta et al published 23 August 2010 in Organometallics

Chlorogenic Compounds from Coffee Beans Exert Activity against Respiratory Viruses.

scientific article published on 2 November 2016

Computational Design of New Cyclic Urea Inhibitors for Improved Binding of HIV-1 Aspartic Protease

article

Corrigendum to “Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma” [Biosens. Bioelectron. 86 (2016) 913–919]

scientific article published on 23 March 2017

Cyclization of γ,δ-epoxy-α-cyanosulphones. A simple, diastereoselective route to cyclopropane carboxylic acids

Design of peptidomimetic inhibitors of aspartic protease of HIV-1 containing -Phe Psi Pro- core and displaying favourable ADME-related properties.

scientific article published on 26 June 2008

Designing Short Peptides with High Affinity for Organic Molecules: A Combined Docking, Molecular Dynamics, And Monte Carlo Approach.

scientific article published on 28 February 2012

Development and evaluation of an immunoassay for the monitoring of the anti-HIV drug amprenavir

article

Efficient Biginelli Synthesis of 2-Aminodihydropyrimidines under Microwave Irradiation

Efficient chemoenzymatic synthesis of chiral pincer ligands

scientific article

Electron impact induced deamination of 1-sulphonylamino-1,2,3-triazoles

scholarly article by Fabio Benedetti et al published November 1988 in Journal of Mass Spectrometry

Electron impact mass spectrometry of some geminal bis-sulphones

scholarly article by Fabio Benedetti et al published August 1988 in Journal of Mass Spectrometry

Elimination and addition reactions. Part 40. The insignificant effect of strain in higher order eliminations in 1,1-bis(phenylsulphonyl) carbanions with ω-leaving groups

article

Epoxyalcohol route to hydroxyethylene dipeptide isosteres. Stereodivergent synthesis of the diamino alcohol core of ritonavir and its C-2 epimer.

scientific article

Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

article

Facile inversion of configuration of N-Boc-β-aminoalcohols via SN2 cyclization to oxazolidinones

Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma

scientific article published on 26 July 2016

GRID/tetrahedral intermediate computational approach to the study of selectivity of penicillin G acylase in amide bond synthesis

scientific article published in November 2002

Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor.

scientific article published on 14 July 2014

Intramolecular Ring Opening of Epoxides by Bis-Activated Carbanions. The Influence of Ring Size on Reactivity and Selectivity

Methyl effects in the cyclization of .gamma.-epoxy bis-sulfones

Modeling of solvent effects in the activation of the lipase from Rhizomucor miehei

scientific article published in 1996

New synthesis of 5-amino-4-hydroxy-2,6-dimethylheptanoic acid, a hydroxyethylene isostere of the Val-Ala dipeptide

Nucleophilic addition to styryl sulphones. Part I

article

Nucleophilic addition to styryl sulphones. part II. Regio- and stereochemistry of the addition of enamines from 4-substituted cyclohexanones

article

Nutrient utilisation and particulate organic matter changes during summer in the upper mixed layer (Ross Sea, Antarctica)

article

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

scientific article published on 10 September 2020

Pure, homo-bifunctional poly(ethylene glycol) orthogonally protected: synthesis and characterisation

Purification and characterization of l,(l/d)-aminopeptidase from Guinea pig serum

scientific article published in January 2006

Regio- and stereoselective ring opening of 2,3-epoxyalcohols with diethylaluminium azide

Regiospecificity in nucleophilic displacement of aromatic nitro-groups

Ring-opening of epoxyalcohols by diethylaluminium cyanide. Regio- and stereoselective synthesis of 1-cyano-2,3-diols

Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases.

scientific article published in November 2003

Stereoselective Hydroazidation of Amino Enones: Synthesis of the Ritonavir/Lopinavir Core

scientific article published on 01 January 2006

Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxyalcohols derived from α-amino acids

scientific article published on 01 October 1999

Strategies for Delivery of siRNAs to Ovarian Cancer Cells

scientific article published on 22 October 2019

Structure Based Design of Inhibitors of Aspartic Protease of HIV-1

article

Synthesis and Antiviral Activity of Novel Adamantylpeptides

scholarly article by Branka Vrane?i? et al published 30 June 1993 in Helvetica Chimica Acta

Synthesis and Biological Activity of New Mixed HIV-PR Inhibitors Conjugated to Bifunctional High-Molecular Weight Poly(Ethylene Glycol)

article

Synthesis and application of new mixed, polymer-conjugated drugs. Use of selectively end-modified poly(ethylene glycol)

Synthesis and biological activity of potent HIV-1 protease inhibitors based on Phe-Pro dihydroxyethylene isosteres

scientific article published on 17 April 2012

Synthesis and biological evaluation in vitro and in mammalian cells of new heteroaryl carboxyamides as HIV-protease inhibitors.

scientific article published on 11 July 2017

Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters

scientific article published on 21 June 2016

Synthesis of a Val-Pro diaminodiol dipeptide isostere by epoxyamine cyclization.

scientific article

Synthesis of all stereoisomers of cognac lactones via microbial reduction and enzymatic resolution strategies

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

scientific article published on 12 February 2015

The base-catalysed cyclisation of ω-epoxy 1,1-bis-sulphones. Reactivity and selectivity as a function of ring size

The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.

scientific article published on 7 February 2018

The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells

scientific article published on 31 May 2016

The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line

scientific article published on January 2006

Unexpected 1,2,3-triazole formation in the reaction of diethylaluminum azide with α′-amino-α,β-unsaturated ketones

Val-Ala Dipeptide Isosteres by Hydrocyanation of α′-Amino α,β-Unsaturated Ketones − Control of Stereoselectivity by the N-Protecting Group

Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Pseudopeptide HIV Protease Inhibitors

article

List of works by Fabio Benedetti

1-Arylsulfonylamino-1,2,3-triazole derivatives from functionalyzed 1,2-cyclohexanediones

1-Substituted morpholino ethenes—III

A Potent HIV Protease Inhibitor Identified in an Epimeric Mixture by High-Resolution Protein Crystallography

A catalytic antibody programmed for torsional activation of amide bond hydrolysis

A competitive immunoassay for the detection of esterolytic activity of antibodies and enzymes.

A study of the molecular structure and spectroscopic properties of polycyclic polyaza-compounds with diamond-lattice conformations

Addressing the Poly- to Oligo-ketone Selectivity in Styrene Carbonylation Catalyzed by Palladium/bpy Complexes. Effect of the 6-Alkyl Substitution

Albumin-controlled stereoselective reduction of 1,3-diketones to anti-diolsElectronic supplementary information (ESI) available: Scatchard and Lineweaver–Burk plots. See http://www.rsc.org/suppdata/cc/b2/b200474g/

Albumin-directed stereoselective reduction of 1,3-diketones and β-hydroxyketones to anti diols

Aldolase activity of serum albumins.

An Unprecedented Catalytic Motif Revealed in the Model Structure of Amide Hydrolyzing Antibody 312d6

An albumin-derived peptide scaffold capable of binding and catalysis

An enzyme‐linked immunosorbent assay for the direct analysis of beta‐agonist drugs in urine and sera

Antibody catalyzed modification of amino acids. Efficient hydrolysis of tyrosine benzoate

Aspartic protease inhibitors

Chiral Pincer Ruthenium and Osmium Complexes for the Fast and Efficient Hydrogen Transfer Reduction of Ketones

Chlorogenic Compounds from Coffee Beans Exert Activity against Respiratory Viruses.

Computational Design of New Cyclic Urea Inhibitors for Improved Binding of HIV-1 Aspartic Protease

Corrigendum to “Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma” [Biosens. Bioelectron. 86 (2016) 913–919]

Cyclization of γ,δ-epoxy-α-cyanosulphones. A simple, diastereoselective route to cyclopropane carboxylic acids

Design of peptidomimetic inhibitors of aspartic protease of HIV-1 containing -Phe Psi Pro- core and displaying favourable ADME-related properties.

Designing Short Peptides with High Affinity for Organic Molecules: A Combined Docking, Molecular Dynamics, And Monte Carlo Approach.

Development and evaluation of an immunoassay for the monitoring of the anti-HIV drug amprenavir

Efficient Biginelli Synthesis of 2-Aminodihydropyrimidines under Microwave Irradiation

Efficient chemoenzymatic synthesis of chiral pincer ligands

Electron impact induced deamination of 1-sulphonylamino-1,2,3-triazoles

Electron impact mass spectrometry of some geminal bis-sulphones

Elimination and addition reactions. Part 40. The insignificant effect of strain in higher order eliminations in 1,1-bis(phenylsulphonyl) carbanions with ω-leaving groups

Epoxyalcohol route to hydroxyethylene dipeptide isosteres. Stereodivergent synthesis of the diamino alcohol core of ritonavir and its C-2 epimer.

Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

Facile inversion of configuration of N-Boc-β-aminoalcohols via SN2 cyclization to oxazolidinones

Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma

GRID/tetrahedral intermediate computational approach to the study of selectivity of penicillin G acylase in amide bond synthesis

Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor.

Intramolecular Ring Opening of Epoxides by Bis-Activated Carbanions. The Influence of Ring Size on Reactivity and Selectivity

Methyl effects in the cyclization of .gamma.-epoxy bis-sulfones

Modeling of solvent effects in the activation of the lipase from Rhizomucor miehei

New synthesis of 5-amino-4-hydroxy-2,6-dimethylheptanoic acid, a hydroxyethylene isostere of the Val-Ala dipeptide

Nucleophilic addition to styryl sulphones. Part I

Nucleophilic addition to styryl sulphones. part II. Regio- and stereochemistry of the addition of enamines from 4-substituted cyclohexanones

Nutrient utilisation and particulate organic matter changes during summer in the upper mixed layer (Ross Sea, Antarctica)

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Pure, homo-bifunctional poly(ethylene glycol) orthogonally protected: synthesis and characterisation

Purification and characterization of l,(l/d)-aminopeptidase from Guinea pig serum

Regio- and stereoselective ring opening of 2,3-epoxyalcohols with diethylaluminium azide

Regiospecificity in nucleophilic displacement of aromatic nitro-groups

Ring-opening of epoxyalcohols by diethylaluminium cyanide. Regio- and stereoselective synthesis of 1-cyano-2,3-diols

Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases.

Stereoselective Hydroazidation of Amino Enones: Synthesis of the Ritonavir/Lopinavir Core

Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxyalcohols derived from α-amino acids

Strategies for Delivery of siRNAs to Ovarian Cancer Cells

Structure Based Design of Inhibitors of Aspartic Protease of HIV-1

Synthesis and Antiviral Activity of Novel Adamantylpeptides

Synthesis and Biological Activity of New Mixed HIV-PR Inhibitors Conjugated to Bifunctional High-Molecular Weight Poly(Ethylene Glycol)

Synthesis and application of new mixed, polymer-conjugated drugs. Use of selectively end-modified poly(ethylene glycol)

Synthesis and biological activity of potent HIV-1 protease inhibitors based on Phe-Pro dihydroxyethylene isosteres

Synthesis and biological evaluation in vitro and in mammalian cells of new heteroaryl carboxyamides as HIV-protease inhibitors.

Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters

Synthesis of a Val-Pro diaminodiol dipeptide isostere by epoxyamine cyclization.

Synthesis of all stereoisomers of cognac lactones via microbial reduction and enzymatic resolution strategies

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

The base-catalysed cyclisation of ω-epoxy 1,1-bis-sulphones. Reactivity and selectivity as a function of ring size

The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.

The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells

The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line

Unexpected 1,2,3-triazole formation in the reaction of diethylaluminum azide with α′-amino-α,β-unsaturated ketones

Val-Ala Dipeptide Isosteres by Hydrocyanation of α′-Amino α,β-Unsaturated Ketones − Control of Stereoselectivity by the N-Protecting Group

Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Pseudopeptide HIV Protease Inhibitors

anti-Sulfonamide antibodies catalyse the hydrolysis of a heterocyclic amide