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List of works by René L. Jacobs

A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans

scientific article

A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes.

scientific article published on 17 November 2011

Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance ⬇️

scientific article published on 18 March 2010

Antimicrobial activity in the egg wax of the tick Amblyomma hebraeum (Acari: Ixodidae) is associated with free fatty acids C16:1 and C18:2

scientific article published on 13 June 2012

Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism

scientific article published on 11 January 2015

Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice ⬇️

scientific article published on June 18, 2012

Choline deficiency impairs intestinal lipid metabolism in the lactating rat.

scientific article

Choline is required in the diet of lactating dams to maintain maternal immune function.

scientific article published on 23 April 2015

Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action

scientific article

Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet

scientific article

Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation

scientific article published on 07 September 2014

Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet

scientific article published on 31 August 2011

Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.

scientific article

Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice

scientific article published on 15 November 2014

Dietary creatine supplementation lowers hepatic triacylglycerol by increasing lipoprotein secretion in rats fed high-fat diet.

scientific article

Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome

scientific article published on 18 March 2014

Differential expression of hypothalamic, metabolic and inflammatory genes in response to short-term calorie restriction in juvenile obese- and lean-prone JCR rats

scientific article

Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat

scientific article published on 01 December 1998

Egg Consumption and Cardiovascular Risk.

scientific article

Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion.

scientific article published on 30 January 2013

Estimation of choline intake from 24 h dietary intake recalls and contribution of egg and milk consumption to intake among pregnant and lactating women in Alberta

scientific article published on 08 April 2014

Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats

scientific article published on 23 September 2016

Feeding a Mixture of Choline Forms during Lactation Improves Offspring Growth and Maternal Lymphocyte Response to Ex Vivo Immune Challenges.

scientific article published on 7 July 2017

Feeding a Mixture of Choline Forms to Lactating Dams Improves the Development of the Immune System in Sprague-Dawley Rat Offspring.

scientific article

Feeding a diet devoid of choline to lactating rodents restricts growth and lymphocyte development in offspring

article

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

scientific article published on 3 February 2017

Finding the balance: The role of S -adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease ⬇️

scientific article published on August 14, 2013

Folate, vitamin B12, and vitamin B6 status of a group of high socioeconomic status women in the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort

scientific article published in December 2014

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice

scientific journal article

Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology

scientific article

Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice.

scientific article

Impact of Egg Consumption on Cardiovascular Risk Factors in Individuals with Type 2 Diabetes and at Risk for Developing Diabetes: A Systematic Review of Randomized Nutritional Intervention Studies.

scientific article published on 27 March 2017

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity

scientific article

Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction

scientific article

Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity

scientific article published on 29 August 2007

Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation

scientific article published on 19 December 2006

Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT.

scientific article published on 25 June 2015

Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms

scientific article published on 17 November 2010

Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis

scholarly article by John P Kennelly et al published September 2018 in Journal of Lipid Research

Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress

scientific article published on 18 September 2015

Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice

scientific article

Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle

scientific article published on 18 November 2015

Measurement of the abundance of choline and the distribution of choline-containing moieties in meat

scientific article

Methylation demand and homocysteine metabolism

scientific article published in January 2004

Novel insights on interactions between folate and lipid metabolism.

scientific article

Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis ⬇️

scientific article published on July 1, 2011

Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.

scientific article published on 15 June 2005

Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice

scientific article

Regulation of homocysteine metabolism

scientific article published on 01 January 1999

Riboflavin Deficiency in Rats Decreases de novo Formate Production but Does Not Affect Plasma Formate Concentration.

scientific article published on 25 January 2017

Simultaneous determination of trimethylamine and trimethylamine N-oxide in mouse plasma samples by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry

scientific article published on 21 December 2016

Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis.

scientific article published on October 2010

Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins.

scientific article

The Form of Choline in the Maternal Diet Affects Immune Development in Suckled Rat Offspring

article

The concentration of phosphatidylethanolamine in mitochondria can modulate ATP production and glucose metabolism in mice

scientific article published on 27 March 2014

The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease

scientific article published on 11 April 2017

The dietary form of choline during lactation affects maternal immune function in rats.

scientific article published on 30 June 2017

Tissue Specific Effects of Dietary Carbohydrates and Obesity on ChREBPα and ChREBPβ Expression

scientific article published on 2 November 2015

Total Choline and Choline-Containing Moieties of Commercially Available Pulses

scientific article published on 01 June 2014

Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

scientific article published on September 2016

Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease

scientific article published on 01 December 2020

Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.

scientific article published on 27 November 2014

Validation of an LC-MS/MS method for the quantification of choline-related compounds and phospholipids in foods and tissues.

scientific article

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