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List of works by Michael Kracht

A comprehensive map of the IL-1R signalling network.

scientific article published on 26 February 2009

Activation of NF-kappaB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades

scientific article published on December 2003

Activation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C

scientific article published on 01 March 1990

C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages

scientific article

CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response

scientific article published on 15 May 2020

CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties

scientific article published in November 2008

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

scientific article published on 31 August 2009

Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells

scientific article published on October 2006

Cellular gene expression that correlates with EBER expression in Epstein-Barr Virus-infected lymphoblastoid cell lines

scientific article published on 19 January 2011

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

scientific article published on 25 June 2019

Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes

scientific article published on 27 July 2004

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

scientific article

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer

scientific article

Correction: Riedlinger, T. et al. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-In Mice. Biomedicines, 2018, 6, 36.

scientific article published on 16 May 2018

Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression

scientific article published on 21 December 2015

Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression

scientific article published on 2 January 2014

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

scientific article

Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells

scientific article published on 27 July 2011

Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2.

scientific article

Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes

scientific article published on 27 June 2003

Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

scientific article published on 07 November 2019

Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.

scientific article

Dynamic mRNP Remodeling in Response to Internal and External Stimuli

scientific article published on 11 September 2020

Evidence for general stabilization of mRNAs in response to UV light

scientific article published on 01 December 2002

Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets

scientific article

Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus

scientific article

HIPK family kinases bind and regulate the function of the CCR4-NOT complex.

scientific article published on 27 April 2016

Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals

scientific article published on 17 August 2006

Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages

scientific article published on 31 January 2012

IL-1 family nomenclature

scientific article

IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA

scientific article published on 01 November 2016

IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA.

scientific article

Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus

scientific article

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

scientific article

Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse

scientific article

Identification of composite promoter modules in inflammation-regulated genes.

scientific article published on 26 February 2009

Identification of mouse genes with highly specific expression patterns in differentiated intestinal epithelium

scientific article published on 01 March 2006

Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis

scientific article

Identification of two forms of TNF tolerance in human monocytes: differential inhibition of NF-κB/AP-1- and PP1-associated signaling

scientific article published on 26 February 2014

Inducible expression of a constitutively active mutant of mitogen-activated protein kinase kinase 7 specifically activates c-JUN NH2-terminal protein kinase, alters expression of at least nine genes, and inhibits cell proliferation

scientific article

Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

scientific article published on 3 January 2006

Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions

scientific article published on 01 October 2006

Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signaling

scientific article

Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway

scientific article

Inhibition of mRNA deadenylation and degradation by different types of cell stress

scientific article published on 01 March 2006

Inhibition of mRNA deadenylation and degradation by ultraviolet light

scientific article

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

scientific article

Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells

scientific article published on 01 October 1996

Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver

scientific article published on December 1994

Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells

scientific article published on 01 November 1993

Interleukin-1 (IL-1) pathway

scientific article

Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.

scientific article published on September 1994

Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism

scientific article published on 27 July 2011

Interleukin-1 induced signalling: biphasic activation of mitogen-activated protein kinase kinase and mitogen-activated protein kinases in HeLa cells. Involvement of phosphoprotein phosphatases

scientific article published on 01 December 1996

Interleukin-1-induced signaling in T-cells. Evidence for the involvement of phosphatases PP1 and PP2A in regulating protein kinase C-mediated protein phosphorylation and interleukin-2 synthesis

scientific article published on 01 October 1993

Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1

scientific article published on 8 May 2013

Interleukin-1beta (IL-1beta) processing pathway

scientific article published on 19 January 2010

Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification

scientific article published in September 2005

Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis

scientific article

Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma

scientific article published on 11 September 2008

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

scientific article published on June 2016

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.

scientific article

Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression

scientific article

MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors

scientific article

MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells

scientific article

Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal α-toxin

scientific article published on 12 September 2011

Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus

scientific article published on 18 October 2006

Molecular mechanisms of T lymphocyte activation: convergence of T cell antigen receptor and IL-1 receptor-induced signaling at the level of IL-2 gene transcription

scientific article published on 01 November 1999

Multi-level inhibition of coronavirus replication by chemical ER stress

scientific article published on 20 September 2021

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

scientific article published on 9 April 2010

NF-kappaB: a multifaceted transcription factor regulated at several levels

scientific article

NF-κB-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4)

scientific article published on February 2013

NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

scientific article published on August 2004

Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner

scientific article published on 27 April 2009

Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways

scientific article

Peptides as signaling inhibitors for mammalian MAP kinase cascades

scientific article published on January 2009

Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

scientific article

Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity

scientific article

Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells

scientific article published on 18 November 2005

Proliferation status defines functional properties of endothelial cells

scientific article published on 16 November 2016

Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation in human endothelial cells through induction of AP-1.

scientific article

Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.

scientific article published on September 1995

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

scientific journal article

Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor

scientific article

Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ.

scientific article

Regulation of cytokine transcription by common stress kinase cascades

scientific article published on 01 September 2000

Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease

scientific article

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation

scientific article

Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7

scientific article published on 01 November 1997

Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines

scientific article published on 20 July 2011

Silencing or permanent activation: host-cell responses in models of persistent Chlamydia pneumoniae infection

scientific article published on August 2005

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

scientific article

Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NFkappaB-MAPK signaling pathways

scientific article

Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor

scientific article published on 13 October 2004

Stress-activated Protein Kinase/Jun N-terminal Kinase Is Required for Interleukin (IL)-1-induced IL-6 and IL-8 Gene Expression in the Human Epidermal Carcinoma Cell Line KB ⬇️

scientific article published on September 11, 1998

Targeting innate immunity protein kinase signalling in inflammation

scientific article published on June 2009

Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases

scientific article published in January 2017

The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.

scientific article published on 4 February 2015

The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription

scientific article published on 14 June 2017

The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection

scientific article published on 16 May 2018

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB

scientific article

The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation

scientific article published on 24 October 2000

The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element.

scientific article

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells.

scientific article

The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

scientific article

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

scientific article published on 19 October 2012

The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation

scientific article published on February 2014

The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin

scientific article published on October 2003

The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells

scientific article published on 7 November 2013

The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)

scientific article

The intricate interplay between RNA viruses and NF-κB.

scientific article published on 10 August 2014

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

scientific article published on 9 October 2006

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

scientific article published on September 1999

Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts

scientific article published on 18 February 2011

Transcriptional and post-transcriptional control of gene expression in inflammation

scientific article

Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway

scientific article published on 15 February 2008

Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation

scientific article published on 24 October 2013

Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import

scientific article

Yersinia enterocolitica YopP inhibits MAP kinase-mediated antigen uptake in dendritic cells

scientific article

c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies

scientific article

c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene

scientific article published on 28 April 2008

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