Search filters

List of works by Jan­ne Back­man

A time-to-event model for acute rejections in paediatric renal transplant recipients treated with ciclosporin A.

scientific article published on October 2013

An early Eocene carbon cycle perturbation at ∼52.5 Ma in the Southern Alps: Chronology and biotic response

article

Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin

scientific article published on 04 May 2011

Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response

scientific article published in October 2012

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

scientific article published on 22 September 2009

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel

scientific article published on 20 August 2018

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

scientific article

Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo

scientific article

Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation.

scientific article

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .

scientific article

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin

article

Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel

scientific article published on 09 August 2018

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

scientific article

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

scientific article published on 10 January 2019

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

scientific article published on 24 November 2017

Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide

scientific article published in August 2005

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics

scientific article published on 23 September 2017

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

scientific article published on 01 February 2019

Cyclosporine A monitoring ? how to account for twice and three times daily dosing

scientific article published on 17 March 2005

Cyclosporine markedly raises the plasma concentrations of repaglinide

scientific article

Cytochrome P450 in Pharmacogenetics: An Update

scientific article published on 01 January 2018

Developmental pharmacokinetics of ciclosporin--a population pharmacokinetic study in paediatric renal transplant candidates.

scientific article published on 27 July 2007

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

scientific article published on 05 May 2019

Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

scientific article published on 21 July 2011

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

scientific article

Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications ⬇️

scientific article published on 02 April 2012

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

scientific article

Effect of fluconazole on the pharmacokinetics and pharmacodynamics of nateglinide

scientific article published in July 2003

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects

scientific article published in April 2005

Effect of grapefruit juice on the bioactivation of prasugrel

scientific article published in June 2015

Effect of rifampicin on the pharmacokinetics of pioglitazone

scientific article published in January 2006

Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial

scientific article published in January 2014

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

scientific article published on 8 October 2017

Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

scientific article published on 28 March 2007

Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine

scientific article published on 23 October 2007

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

scientific article published on 06 January 2015

Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone

scientific article published in September 2004

Enantiospecific Pharmacogenomics of Fluvastatin

scientific article published on 14 May 2019

Episodic fresh surface waters in the Eocene Arctic Ocean

scientific article (publication date: June 2006)

Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations

Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review

article

Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in a Finnish population

article

Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

scientific article published on 01 May 2012

Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.

scientific article published on 8 May 2013

Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings

scientific article published on 7 October 2011

Genome‐Wide Association Study of Atorvastatin Pharmacokinetics: Associations With <i>SLCO1B1</i>, <i>UGT1A3</i>, and <i>LPP</i>

scientific article published on 17 March 2024

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

scientific article published on 27 June 2014

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

scientific article published on June 2013

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

scientific article

Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide

scientific article

In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions

scientific article published on 09 August 2018

In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors

scientific article published on 8 April 2014

In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions

scientific article published in August 2008

Intravenous Lipid Emulsion Entraps Amitriptyline into Plasma and Can Lower its Brain Concentration - An Experimental Intoxication Study in Pigs

scientific article published on 29 May 2013

Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity

scientific article published on 7 October 2014

Introduction of an electrochemical point‐of‐care assay for quantitative determination of paracetamol in finger‐prick capillary whole blood samples

scientific article published on 7 June 2023

Itraconazole Increases Ibrutinib Exposure 10-Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug-Drug Interaction

scientific article published on 29 November 2019

Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren

scholarly article by Tuija Tapaninen et al published March 2011 in The Journal of Clinical Pharmacology

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

article published in 2006

Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism

scientific article published on 27 January 2010

Major perturbations in the global carbon cycle and photosymbiont-bearing planktic foraminifera during the early Eocene

Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

scientific article published on 02 March 2011

Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma

scientific article published on 7 October 2015

No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin

scientific article published on August 2009

No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid

Pharmacokinetics and bone effects of budesonide in primary biliary cirrhosis

scientific article published on 01 December 2006

Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury

scientific article published on 5 October 2016

Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide

scientific article published on 31 January 2006

Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients

scientific article (publication date: February 2006)

Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing

scientific article published on March 2015

Posaconazole‐ibrutinib interaction cannot be avoided by staggered dosing: How to optimize ibrutinib dose during posaconazole treatment

scientific article published on 13 November 2023

Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates.

scientific article published on April 2012

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.

scientific article published on 11 December 2017

Pulmonary administration of a dry powder formulation of the antifibrotic drug tilorone reduces silica-induced lung fibrosis in mice.

scientific article published on 12 April 2018

Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations

scientific article published on 02 February 2011

Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?"

scientific article published on 17 September 2018

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects

scientific article

Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine

scientific article published on 27 April 2006

Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

scientific article

Rofecoxib Is a Potent, Metabolism-Dependent Inhibitor of CYP1A2: Implications for in Vitro Prediction of Drug Interactions

scientific article published on 19 September 2006

Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects

scientific article published in September 2006

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

scientific article published on January 2016

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

scientific article

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren

scientific article published in January 2013

Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes – detailed studies on CYP3A inhibitors

scientific article published in July 2024

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

scientific article published on 26 March 2009

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

scientific article published on 15 February 2017

Stable isotope and calcareous nannofossil assemblage record of the late Paleocene and early Eocene (Cicogna section)

Subtropical Arctic Ocean temperatures during the Palaeocene/Eocene thermal maximum

scientific article (publication date: June 2006)

Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis--A randomised placebo-controlled pilot trial

scientific article

Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide

scientific article published on 7 February 2006

The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast

scientific article published on 08 October 2010

The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone

scientific article published on 11 July 2006

The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects

scientific article published in April 2004

The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs

scientific article published on 24 May 2016

Ticagrelor Increases Exposure to the Breast Cancer Resistance Protein Substrate Rosuvastatin

scientific article published on 20 October 2023

Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation

scientific article

Use of busulfan in conditioning for allogeneic hematopoietic stem cell transplantation in adults: a survey by the Transplant Complications Working Party of the EBMT

scientific article published on 03 June 2019

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

scientific article published on 31 October 2016

Voriconazole greatly increases the exposure to oral buprenorphine

scientific article published on 30 August 2018

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

scientific article published on 10 August 2016

Paulina is supported by:

About Paulina

Help