List of works - Thomas Durek

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins ⬇️

scientific article

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

scientific article published on 27 March 2020

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

scientific article published on 25 July 2019

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

scientific article published on 17 March 2016

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

scientific article published in January 2005

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

scientific article published on 13 November 2015

Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

scientific article

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

scientific article published on 11 June 2020

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

scientific article

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1

scientific article

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

scientific article published on 21 March 2009

Chemical synthesis and structure of the prokineticin Bv8

scientific article

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

scientific article

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

scientific article published on 22 December 2017

Combining Sense and Nonsense Codon Reassignment for Site-Selective Protein Modification with Unnatural Amino Acids.

scientific article

Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction

scientific article published on 23 June 2016

Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme

scientific article

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

scientific article published on 29 August 2015

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

scientific article published on 31 March 2018

Disulfide-rich macrocyclic peptides as templates in drug design

scientific article published on 06 March 2014

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

scientific article published on 18 December 2015

Efficient chemical synthesis of human complement protein C3a

scientific article

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

scientific article

Fmoc-based synthesis of disulfide-rich cyclic peptides

scientific article published on 11 June 2014

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

scientific article published on 26 December 2018

Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro

scientific article

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.

scientific article published on 30 November 2017

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

scientific article

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

scientific article published on 25 October 2016

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

scientific article published on 19 February 2014

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

scientific article published on 15 February 2017

Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs

scientific article published on 08 December 2015

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.

scientific article published on 20 June 2018

NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency

scientific article published on 22 October 2018

Neurotoxic peptides from the venom of the giant Australian stinging tree

scientific article published on 16 September 2020

Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant ⬇️

scientific article published on 8 August 2016

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

scientific article published on 03 April 2019

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

scientific article published on 23 October 2015

Preformed selenoesters enable rapid native chemical ligation at intractable sites

scientific article published on 13 October 2011

Protein semi-synthesis: new proteins for functional and structural studies.

scientific article

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase

scientific article published on 16 October 2019

Solid phase synthesis of peptide-selenoesters.

scientific article published on 6 April 2013

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

scientific article

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

scientific article

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

scientific article published on 01 April 2005

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

scientific article published in December 2004

Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein

scientific article published on 28 November 2007

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

scientific article published on 05 October 2018

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.

scientific article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

scientific article

Therapeutic conotoxins: a US patent literature survey

scientific article published on 12 June 2015

Total chemical synthesis, folding, and assay of a small protein on a water-compatible solid support

scientific article published on 01 May 2006

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency

scientific article published on 20 October 2020

List of works by Thomas Durek

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins ⬇️

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

Chemical synthesis and structure of the prokineticin Bv8

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

Combining Sense and Nonsense Codon Reassignment for Site-Selective Protein Modification with Unnatural Amino Acids.

Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein Interaction

Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Disulfide-rich macrocyclic peptides as templates in drug design

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Efficient chemical synthesis of human complement protein C3a

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

Fmoc-based synthesis of disulfide-rich cyclic peptides

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

Modulation of human Nav1.7 channel gating by synthetic α-scorpion toxin OD1 and its analogs

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.

NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency

Neurotoxic peptides from the venom of the giant Australian stinging tree

Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant ⬇️

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

Preformed selenoesters enable rapid native chemical ligation at intractable sites

Protein semi-synthesis: new proteins for functional and structural studies.

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase

Solid phase synthesis of peptide-selenoesters.

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Therapeutic conotoxins: a US patent literature survey

Total chemical synthesis, folding, and assay of a small protein on a water-compatible solid support

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency