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List of works by Keith E. Shearwin

A mathematical model for transcriptional interference by RNA polymerase traffic in Escherichia coli

scientific article published on 23 December 2004

A quantitative binding model for the Apl protein, the dual purpose recombination-directionality factor and lysis-lysogeny regulator of bacteriophage 186

scientific article published on 13 August 2020

AMHY and sex determination in egg-laying mammals

scientific article published on 21 April 2024

APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting <i>Staphylococcus aureus</i> and MRSA Biofilms

scientific article published on 30 May 2022

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

scientific article published on 06 April 2020

Allowance for thermodynamic nonideality and Donnan effects in binding studies. Activity coefficients of charged ligands in the presence of albumin

scientific article published on 01 August 1990

Analysis of Infection Time Courses Shows CII Levels Determine the Frequency of Lysogeny in Phage 186

scientific article published on 29 September 2021

Aspects of protein-DNA interactions: a review of quantitative thermodynamic theory for modelling synthetic circuits utilising LacI and CI repressors, IPTG and the reporter gene lacZ.

scientific article

Bacteriophage lambda repressor mediates the formation of a complex enhancer-like structure

scientific article

Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin.

scientific article

Characterizing Transcriptional Interference between Converging Genes in Bacteria

scientific article published on 14 February 2019

Clonetegration Using OSIP Plasmids: One-Step DNA Assembly and Site-Specific Genomic Integration in Bacteria.

scientific article published in January 2017

Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68

scientific article published on 02 July 2019

Cooperativity in long-range gene regulation by the lambda CI repressor.

scientific article published on February 2004

Cro's role in the CI Cro bistable switch is critical for {lambda}'s transition from lysogeny to lytic development

scientific article

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

scientific article published on 16 January 2021

Directing traffic on DNA-How transcription factors relieve or induce transcriptional interference.

scientific article published on 27 January 2017

Effect of calcium ion on the dimerization of alpha-chymotrypsin

scientific article published on 01 March 1990

Effect of colchicine analogues on the dissociation of alpha beta tubulin into subunits: the locus of colchicine binding

scientific article published on 01 February 1994

Effects of thermodynamic nonideality on the kinetics of ester hydrolysis by alpha-chymotrypsin: a model system with preexistence of the isomerization equilibrium.

scientific article published in October 1989

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

scientific article published in 2022

Efficient chromosomal-scale DNA looping in Escherichia coli using multiple DNA-looping elements

scientific article

Enhancer-like long-range transcriptional activation by λ CI-mediated DNA looping

scientific article published on 4 February 2013

Establishing lysogenic transcription in the temperate coliphage 186.

scientific article

Functional alignment of regulatory networks: a study of temperate phages

scientific article

Hidden Secrets of Sigma54 Promoters Revealed

scientific article published on 7 November 2017

Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR.

scientific article

Instability of CII is needed for efficient switching between lytic and lysogenic development in bacteriophage 186

scientific article published on 19 November 2020

Linkage between ligand binding and control of tubulin conformation

scientific article published on 01 September 1992

Linkages between the dissociation of alpha beta tubulin into subunits and ligand binding: the ground state of tubulin is the GDP conformation.

scientific article

Mechanisms of biotin-regulated gene expression in microbes

scientific article published on 5 February 2016

Modelling transcriptional interference and DNA looping in gene regulation.

scientific article

Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus

scientific article published on 26 February 2019

One-step cloning and chromosomal integration of DNA.

scientific article

Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat subinhibitory concentrations

scientific article published on 16 May 2021

Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat subinhibitory concentrations

Positive and Negative Control of Enhancer-Promoter Interactions by Other DNA Loops Generates Specificity and Tunability

scientific article published on 01 February 2019

Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter

scientific article published on June 2009

Programmable DNA looping using engineered bivalent dCas9 complexes

scientific article published on 20 November 2017

Promoter activation by CII, a potent transcriptional activator from bacteriophage 186.

scientific article

Prophages encoding human immune evasion cluster genes are enriched in isolated from chronic rhinosinusitis patients with nasal polyps

scientific article published in December 2021

Proteins mediating different DNA topologies block RNAP elongation with different efficiency

scientific article published in 2022

Purification of bacteriophage lambda repressor

scientific article

Quantitation of interactions between two DNA loops demonstrates loop domain insulation in E. coli cells

scientific article

Quantitation of the DNA tethering effect in long-range DNA looping in vivo and in vitro using the Lac and λ repressors.

scientific article published on 16 December 2013

RNA polymerase efficiently transcribes through DNA-scaffolded, cooperative bacteriophage repressor complexes

scientific article published in August 2022

RNA polymerase pausing at a protein roadblock can enhance transcriptional interference by promoter occlusion

scientific article published on 29 March 2019

Repurposing site-specific recombinases for synthetic biology

scientific article published in November 2013

Revisited gene regulation in bacteriophage lambda.

scientific article

Road rules for traffic on DNA-systematic analysis of transcriptional roadblocking in vivo.

scientific article

Simplified heavy-atom derivatization of protein structures via co-crystallization with the MAD tetragon tetrabromoterephthalic acid

scientific article published in May 2021

Single molecule analysis of DNA wrapping and looping by a circular 14mer wheel of the bacteriophage 186 CI repressor

scientific article published on 24 April 2013

Slow growth leads to a switch.

scientific article

Substrate as a source of thermodynamic nonideality in enzyme kinetic studies: invertase-catalyzed hydrolysis of sucrose

scientific article published on 01 February 1988

The Tum protein of coliphage 186 is an antirepressor

scientific article published on 01 March 1998

The helix-turn-helix motif of the coliphage 186 immunity repressor binds to two distinct recognition sequences

scientific article

The loopometer: a quantitative in vivo assay for DNA-looping proteins

scientific article published on 19 April 2021

The pIT5 Plasmid Series, an Improved Toolkit for Repeated Genome Integration in E. coli

scientific article published on 30 June 2021

The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels

scientific article

The role of repressor kinetics in relief of transcriptional interference between convergent promoters

scientific article published on 4 July 2016

The structural basis of cooperative regulation at an alternate genetic switch

scientific article published on 01 March 2006

Thermodynamic nonideality as a probe of reversible protein unfolding effected by variations in pH and temperature: studies of ribonuclease

scientific article published on 01 November 1990

Thermodynamic nonideality in macromolecular solutions. Evaluation of parameters for the prediction of covolume effects

scientific article published on 01 July 1990

Transcriptional interference between convergent promoters caused by elongation over the promoter

scientific article

Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors.

scientific article

Transcriptional interference--a crash course

scientific article

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