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List of works by Clifford J. Woolf

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals

scientific article

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

scientific article

A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain

scientific journal article

A functionally characterized test set of human induced pluripotent stem cells

scientific article published on 3 February 2011

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene

scientific article

A novel tool for the assessment of pain: validation in low back pain

scientific article

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

scientific article

A three-dimensional human neural cell culture model of Alzheimer's disease

scientific article published on 12 October 2014

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

scientific article published on 14 January 2019

ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation

scientific article published on 13 January 2014

ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration

scientific article

Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice

scientific article published on 3 October 2011

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons ⬇️

scientific article published on May 19, 2013

Analgesia by inhibiting tetrahydrobiopterin synthesis ⬇️

scientific article published on December 15, 2011

Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study

scientific article published on 10 November 2015

Author Correction: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

scientific article published in Nature Communications

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

scientific article published in Nature Communications

Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons

scientific journal article

BACE1 regulates voltage-gated sodium channels and neuronal activity

scientific article published on 18 June 2007

Bacteria activate sensory neurons that modulate pain and inflammation

scientific article published on 21 August 2013

Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.

scientific article published in August 2005

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

scientific article

Bradykinin and peripheral sensitization

scientific article

Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity

scientific article published on April 2008

Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.

scientific article published in August 2005

Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis

scientific article published on 04 January 2021

Breaking barriers to novel analgesic drug development

scientific article

Breaking barriers to novel analgesic drug development

scientific article published on 06 October 2017

Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.

scientific article published on January 2014

CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

scientific article

CLP1 links tRNA metabolism to progressive motor-neuron loss

scientific article published on 10 March 2013

CNS injury: IL-33 sounds the alarm

scientific article published on 01 March 2015

COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice

scientific article published on 05 January 2009

Can we conquer pain?

scientific article (publication date: November 2002)

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

scientific article

Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve

scientific article

Capturing Novel Non-opioid Pain Targets

scientific article published on 29 June 2019

Casting light on pain.

scientific article published on March 2014

Central changes in primary afferent fibers following peripheral nerve lesions

scientific article published on 01 April 1997

Central sensitization and LTP: do pain and memory share similar mechanisms?

scientific article

Central sensitization: a generator of pain hypersensitivity by central neural plasticity

scientific article published on September 2009

Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents

scientific article published on July 2009

Collateral sprouting of uninjured primary afferent A-fibers into the superficial dorsal horn of the adult rat spinal cord after topical capsaicin treatment to the sciatic nerve

scientific article published in August 1996

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

scientific article published in Nature Communications

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity

scientific article

Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment

scientific article published on 01 March 2019

Considerations for extrapolating evidence of acute and chronic pain analgesic efficacy ⬇️

scientific article published on March 10, 2011

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception

scientific article

Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis

scientific article published on 15 January 2020

Conversion of mouse and human fibroblasts into functional spinal motor neurons

scientific article

Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

scientific article published on January 2015

DRAGON, a bone morphogenetic protein co-receptor

scientific article

DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties

scientific article (publication date: 25 February 2004)

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms ⬇️

scientific article published on February 23, 2012

Decreased alertness due to sleep loss increases pain sensitivity in mice.

scientific article published on 8 May 2017

Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain

scientific article

Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats

scientific article

Developing nociceptor-selective treatments for acute and chronic pain

Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block

scientific article published in December 2003

Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons.

scientific article published in August 2001

Differential analgesic sensitivity of two distinct neuropathic pain models

scientific article

Diltiazem Promotes Regenerative Axon Growth

scientific article published on 19 September 2018

Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration

scientific article published on July 2014

Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss

scientific article published on 12 October 2003

Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.

scientific article

Dynamic changes in glypican-1 expression in dorsal root ganglion neurons after peripheral and central axonal injury

scientific article published in March 2004

Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

scientific article published in Nature

ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.

scientific article

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

article

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial

scientific article published on 23 November 2020

Endogenous opioid peptides and pain mechanisms: a complex relationship

scientific article published in December 1983

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury

scientific article published on August 2017

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

scientific article

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

scientific article published on 21 September 2020

Exploiting microarrays to reveal differential gene expression in the nervous system

scientific article

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial

scientific article

GAP-43 expression in primary sensory neurons following central axotomy.

scientific article published in July 1994

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function

scientific article published on July 2008

GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord

scientific article

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

scientific journal article

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

scientific article

Heat Shock Protein 27: Developmental Regulation and Expression after Peripheral Nerve Injury ⬇️

scientific article published on August 1, 1998

High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons ⬇️

scientific article published on September 1, 2003

Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival

scientific article published in September 2002

Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent

scientific article published on 01 February 1996

Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.

scientific article

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.

scientific article published in November 1996

Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers

scientific article

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

scientific article

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics

scientific article published on 30 April 2015

Injury-induced plasticity of the flexor reflex in chronic decerebrate rats

article by C J Woolf & Stephen B McMahon published 1 October 1985 in Neuroscience

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

scientific article published on 3 April 2014

Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

scientific article published in September 2004

Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure.

scientific article published on 31 August 2015

Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine ⬇️

scientific article published on July 15, 1998

Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis.

scientific article

Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.

scientific article published on March 2010

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats

scientific article published on 22 January 2008

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.

scientific article published in January 2018

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

scientific article published on 24 November 2014

Morphine, the NMDA receptor antagonist MK801 and the tachykinin NK1 receptor antagonist RP67580 attenuate the development of inflammation-induced progressive tactile hypersensitivity ⬇️

scientific article published on July 1, 1998

Mouse embryonic stem cells can differentiate via multiple paths to the same state.

scientific article published on 9 October 2017

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1

scientific article

Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy

scientific article

Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

scientific article published on 27 December 2018

Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology

scientific article (publication date: 26 July 2012)

Neuroimmunity: Physiology and Pathology

scientific article

Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes

scientific article published on 20 December 2016

Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration

scientific article published on 01 August 2018

Neuropathic pain: a maladaptive response of the nervous system to damage

scientific article published on January 2009

Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

scientific article published on August 1999

No DREAM, No pain. Closing the spinal gate

scientific article

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

scientific article published in December 1999

Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways

Nociceptors are interleukin-1beta sensors

scientific article published on December 2008

Nociceptors--noxious stimulus detectors

scientific article

Non-surgical mouse model of endometriosis-associated pain that responds to clinically active drugs

scientific article published on 27 February 2020

Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

scientific article published on 25 November 2019

Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia

scientific article published in June 1995

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size

scientific article published on 27 July 2016

Optical cuff for optogenetic control of the peripheral nervous system.

scientific article published on 5 October 2017

Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1

scientific article

Pain TRPs

scientific article

Pain and infection: pathogen detection by nociceptors.

scientific article published on June 2016

Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.

scientific article published in August 2002

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

scientific article

Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion

scientific article published on 9 January 2009

Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord

scientific article published in September 2005

Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation

scientific article

Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn

scientific article published on 7 February 2003

Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons

scientific article published in July 2004

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314

scientific article published on 9 January 2013

Persistent postsurgical pain: risk factors and prevention

scientific article

Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges

scientific article

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

scientific article published in 2022

Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing

scientific article published on January 2013

Progressive tactile hypersensitivity after a peripheral nerve crush: non-noxious mechanical stimulus-induced neuropathic pain

scientific article published in November 2002

Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.

scientific article

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

scientific article published on 01 August 2019

Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin

scientific article published on 15 February 2018

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

scientific article published on 20 November 2019

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype

scientific article published on 18 April 2008

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

scientific article published on June 2015

Reliable Screening for a Pain-Protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms

article

Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn

scientific article

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury

scientific article

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

scientific journal article

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations

scientific article published on July 2015

Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats

scientific article

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

scientific article published on 21 May 2015

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

scientific article published on 01 May 2016

Role of the peripheral benzodiazepine receptor in sensory neuron regeneration

scientific article published in October 2005

Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain

scientific article

Selective up-regulation of the growth arrest DNA damage-inducible gene Gadd45 alpha in sensory and motor neurons after peripheral nerve injury

scientific article published in August 2003

Selectively targeting pain in the trigeminal system

scientific article

Sense and Immunity: Context-Dependent Neuro-Immune Interplay.

scientific article

Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?

scientific article

Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice

scientific article published on 28 November 2019

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

scientific article published on 25 June 2015

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

scientific article published on 04 October 2011

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.

scientific article published on 2 January 2018

Substance P activates Mas-related G protein-coupled receptors to induce itch

scientific article

Synaptic plasticity and central sensitization: author reply

scientific article published on 01 August 2010

T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity.

scientific article

TRPA1 contributes to cold hypersensitivity

scientific journal article

Tachykinin NK1 receptor antagonist RP67580 attenuates progressive hypersensitivity of flexor reflex during experimental inflammation in rats

scientific article published in March 1997

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

scientific article published on 17 October 2016

Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review ⬇️

scientific article published on September 1, 2011

The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling.

scientific article published on December 2011

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity

scientific article

The Role of Iron Regulation in Immunometabolism and Immune-Related Disease

scientific article published on 22 November 2019

The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex

scientific article published in July 2015

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

scientific article published in Nature

The neuropathic pain triad: neurons, immune cells and glia

scientific article published on November 2007

The pathophysiology of chronic pain--increased sensitivity to low threshold A beta-fibre inputs.

scientific article published on August 1994

The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models

scientific article published in April 2002

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

scientific article published on 27 April 2015

The transcription factor ATF-3 promotes neurite outgrowth

scientific article published on 19 May 2006

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

scientific article

Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain

scientific article published on May 2014

Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses

scientific article published on July 2017

Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

scientific article published on 01 September 2021

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections

scientific article published in Nature

Toward a Mechanism-Based Approach to Pain Diagnosis

scientific article published on September 2016

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

scientific article published on 14 August 2020

Transcriptional and posttranslational plasticity and the generation of inflammatory pain

scientific article

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

scientific article

Transient receptor potential channels: targeting pain at the source

scientific article

TrpA1 regulates thermal nociception in Drosophila

scientific article

Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype

scientific article published on 11 December 2020

Understanding chronic inflammatory and neuropathic pain

scientific article published in May 2012

Unraveling the Plastic Peripheral Neuroimmune Interactome

scientific article published on 01 January 2020

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

article

Utilization of an HSV-based amplicon vector encoding the axonal marker hPLAP to follow neurite outgrowth in cultured DRG neurons

scientific article published in January 2004

Vagal sensory neurons drive mucous cell metaplasia

scientific article published on 16 January 2020

Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat

scientific article published on 01 May 1996

p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia

scientific article

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

scientific article published in May 2003

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