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List of works by Martin R. Sprick

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

scientific article

Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin

scientific article published on 15 October 2020

Apoptosis mediated by lentiviral TRAIL transfer involves transduction-dependent and -independent effects

scientific article published on 22 December 2006

Biochemistry and function of the DISC

scientific article published on 01 July 2001

Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

scientific article

Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex.

scientific article published in November 2014

CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.

scientific article

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

scientific article published on 8 February 2016

Cancer stem cells--old concepts, new insights.

scientific article published on 15 February 2008

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

scientific article published on April 2017

Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin

scientific article published on 19 February 2015

Determination of copper speciation in highway stormwater runoff using competitive ligand exchange - Adsorptive cathodic stripping voltammetry

scientific article published on 14 August 2012

Development and characteristics of preclinical experimental models for the research of rare neuroendocrine bladder cancer

scientific article published on 29 June 2013

Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.

scientific article published on July 2004

Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.

scientific article published on 12 March 2014

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

scientific journal article

High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chemotherapy: A retrospective cohort study.

scientific article published on 22 April 2017

Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma.

scientific article published on 11 November 2016

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

scientific article published on 21 April 2013

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma

scientific article

Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer.

scientific article published in October 2016

Label retaining cells in cancer--the dormant root of evil?

scientific article published on 23 April 2013

Martin Leverkus, 1965-2016.

scientific article published on 23 January 2017

NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

scientific article published on 8 November 2007

Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response

scientific article published on 3 November 2017

Potential role of soluble TRAIL in epithelial injury in children with severe RSV infection.

scientific article

Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation.

scientific article published in May 2003

Protein profile of basal prostate epithelial progenitor cells--stage-specific embryonal antigen 4 expressing cells have enhanced regenerative potential in vivo.

scientific article published on 5 February 2016

Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations.

scientific article published on 27 November 2017

Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients

scientific article

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

scholarly article

Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis

scientific article published on 17 December 2007

Survival of pancreatic cancer cells lacking KRAS function.

scientific article

TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window.

scientific article published on March 2007

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a retrospective study in 107 patients

scientific article published on 14 May 2015

The influence of prostatic anatomy and neurotrophins on basal prostate epithelial progenitor cells

scientific article published on 7 October 2015

The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death

scientific article

The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features

scientific article

Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme.

scientific article published on 21 May 2012

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

scientific article (publication date: May 2010)

cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes

scientific article

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