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List of works by Nicolas Chapuis

A dramatic fetal outcome following transplacental transfer of dasatinib

scientific article

A meal served cold

scientific article published on 01 April 2020

A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset

scientific article published in Nature Communications

A pernicious mean corpuscular volume.

scientific article published in January 2018

A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse.

scientific article published on 16 January 2013

APG101 efficiently rescues erythropoiesis in lower risk myelodysplastic syndromes with severe impairment of hematopoiesis

scientific article published on 18 February 2016

Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes.

scientific article published on 16 November 2016

Bortezomib, doxorubicin and dexamethasone association is an effective option for plasma cell leukemia induction therapy.

scientific article

CD13 expression in B cell malignancies is a hallmark of plasmacytic differentiation

scientific article published on 10 September 2018

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy

scientific article published on 28 October 2014

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy.

scientific article published on 17 November 2014

Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients.

scientific article published on 10 April 2007

Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia

scientific article published on 19 October 2016

Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia.

scientific article published on 30 September 2010

Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells.

scientific article published on 31 January 2016

Dyserythropoiesis evaluated by RED score and hepcidin/ferritin levels predicts response to erythropoietin in lower risk myelodysplastic syndromes

scientific article published on 04 October 2018

Flow cytometric detection of dyserythropoiesis: a sensitive and powerful diagnostic tool for myelodysplastic syndromes.

scientific article

High levels of CD34+CD38low/-CD123+ blasts are predictive of an adverse outcome in acute myeloid leukemia: a Groupe Ouest-Est des Leucemies Aigues et Maladies du Sang (GOELAMS) study.

scientific article published on 20 September 2011

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

scientific article published on 10 March 2017

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.

scientific article published on 06 September 2013

Insulin receptor A and IGF-1R in AML - Letter.

scientific article

IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia

scientific article published on 29 July 2010

LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.

scientific article published on July 2011

Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling

scientific article published on 3 October 2017

Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

scientific article

Molecular characterization of a novel mutation in the factor XIII A subunit gene associated with a severe defect and an adulthood diagnosis.

scientific article published in March 2007

Multicentric MFI30 study: Standardization of flow cytometry analysis of CD30 expression in non-Hodgkin lymphoma

scientific article published on 17 August 2020

Multicentric standardized flow cytometry routine assessment of septic patient to predict clinical worsening.

scientific article published on 26 April 2018

Multicentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

scientific article published on 30 January 2015

Optical genome mapping refines cytogenetic diagnostics, prognostic stratification and provides new molecular insights in adult MDS/AML patients

scientific article published in 2022

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

scientific article published on 12 June 2008

PI3K and mTOR signaling pathways in cancer: new data on targeted therapies

scientific article

Pairing MCL-1 inhibition with venetoclax improves therapeutic efficiency of BH3-mimetics in AML

scientific article published on 13 July 2020

Paraneoplastic Hyperleukocytosis Mimicking Hematologic Malignancy Revealing a Localized Lung Cancer

scientific article published on 10 August 2019

Phenotypic landscape of granulocytes and monocytes by multiparametric flow cytometry: A prospective study of a 1-tube panel strategy for diagnosis and prognosis of patients with MDS

scientific article published on 09 September 2019

Plasma cell leukemia revealing a G6PD deficiency

scientific article published in December 2016

Plasma vemurafenib exposure and pre-treatment hepatocyte growth factor level are two factors contributing to the early peripheral lymphocytes depletion in BRAF-mutated melanoma patients

scientific article published on July 2016

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

scientific article

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia

scientific article published on 22 May 2019

Revising flow cytometric mini-panel for diagnosing low-grade myelodysplastic syndromes: Introducing a parameter quantifying CD33 expression on CD34+ cells

scientific article published on 10 July 2018

Risk factors for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia over time: assessment of monocyte count and baseline clinical parameters

scientific article

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.

scientific article

Salvage therapy of Autoimmune Thrombocytopenic Purpura revealing non-Hodgkin Lymphoma by the thrombopoietin receptor agonist romiplostim

Sustained leukemia-free state and molecular response to sorafenib in a patient with chronic myelomonocytic leukemia in transformation driven by homozygous FLT3-ITD malignant hematopoiesis.

scientific article

T-cell large granular lymphocyte leukemia transfomation into aggressive T-cell lymphoma: a report of two cases with molecular characterization

scientific article published on 20 December 2018

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

scientific article

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

scientific article published on 28 July 2010

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

scientific article published on 6 December 2011

The eukaryotic initiating factor 4E protein is overexpressed, but its level has no prognostic impact in acute myeloid leukaemia.

scientific article published on 14 October 2011

The fraction of CD117/c-KIT-expressing erythroid precursors predicts ESA response in low-risk myelodysplastic syndromes

scientific article published on 09 April 2019

Too big for flow

scientific article published on 01 August 2019

Vemurafenib pharmacokinetics and its correlation with efficacy and safety in outpatients with advanced BRAF-mutated melanoma

scientific article published on 25 July 2015

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