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List of works by Pieter Annaert

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Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

scientific article published on 11 August 2016
The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats

scientific article
Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

scientific article
Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs

scientific article
The ontogeny of drug metabolizing enzymes and transporters in the rat

scientific journal article
Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

scientific article published on 7 March 2009
Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica

scientific article published on 17 September 2010
High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients

scientific article published on 21 April 2016
Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

scientific article published on 22 February 2011
Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.

scientific article
Albumin is the main plasma binding protein for indoxyl sulfate and p-cresyl sulfate

scientific article published on 24 January 2013
Clinical determinants of calcineurin inhibitor disposition: a mechanistic review

scientific article published on 25 February 2016
Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

scientific article published on 22 June 2011
Drug precipitation–permeation interplay: Supersaturation in an absorptive environment

scientific article published on July 25, 2012
Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS

scientific article published on 24 September 2009
Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.

scientific article published on 7 November 2013
Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole

scientific article published on 24 April 2010
Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates

scientific article published on 7 November 2013
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

scientific article published on 01 April 1997
Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

scientific article published on 29 October 2009
Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

scientific article
Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.

scientific article
In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

scientific article
Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport

scientific article
Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

scientific article published on 8 August 2016
Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood

scientific article published on 10 October 2014
Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients.

scientific article published on 17 November 2016
Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

scientific article published on 11 April 2016
Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

scientific article published on 02 April 2016
Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.

scientific article published on 21 February 2017
Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

scientific article published on 12 December 2014
Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

scientific article published on 26 November 2014
The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

scientific article published on 07 May 2011
Intestinal behavior of the ester prodrug tenofovir DF in humans

scientific article published on 4 March 2015
Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

scientific article
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

scientific article published on 01 July 1999
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

scientific article
Supersaturation in human gastric fluids

scientific article published on 11 February 2012
Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

scientific article published on 12 January 2015
Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients

scientific article
Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs

scientific article published on 15 July 2011
Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

article
Stability of therapeutic albumin solutions used for molecular adsorbent recirculating system-based liver dialysis.

scientific article published on 28 September 2011
Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling

scientific article published on 11 May 2015
The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.

scientific article published on 8 April 2016
Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

scientific article
MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study

scientific article
Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype

scientific article
Unbound Ritonavir Concentrations in Rat and Human Hepatocytes

scientific article published on 18 May 2015
Integration and validation of the ex vivo human placenta perfusion model

scientific article published on 15 May 2017

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