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List of works by Pieter Annaert

A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood

scientific article published on 03 October 2019

Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood

scientific article published on 10 October 2014

Albumin is the main plasma binding protein for indoxyl sulfate and p-cresyl sulfate

scientific article published on 24 January 2013

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study

scientific article published on 27 September 2018

Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs

scientific article published on 20 July 2020

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

scientific article published on 08 February 2017

Cholestasis Differentially Affects Liver Connexins

scientific article published on 07 September 2020

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

scientific article

Clinical determinants of calcineurin inhibitor disposition: a mechanistic review

scientific article published on 25 February 2016

Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole

scientific article published on 24 April 2010

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

scientific article published on 8 August 2016

Comparison between 2-hydroxypropyl-β-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin for inclusion complex formation with danazol

Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies

scientific article published on September 2010

Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

scientific article published in 2021

Current insights in the complexities underlying drug-induced cholestasis

scientific article published on 01 July 2019

Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.

scientific article published on 21 February 2017

Drug precipitation–permeation interplay: Supersaturation in an absorptive environment ⬇️

scientific article published on July 25, 2012

Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

article

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

scientific article published on 02 April 2016

Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype

scientific article

Effect of Age on The Hepatocellularity Number for Wistar rats

scientific article published on 23 December 2015

Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients.

scientific article published on 17 November 2016

Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels

scientific article published in 2022

Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica

scientific article published on 17 September 2010

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

scientific article published on 12 December 2014

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

scientific article published on 26 November 2014

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

scientific article published on 29 October 2009

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

scientific article published on 22 February 2011

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

scientific article published on 24 October 2017

Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.

scientific article published on 24 April 2017

Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS

scientific article published on 24 September 2009

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat.

scientific article

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.

scientific article published on 7 November 2013

High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients

scientific article published on 21 April 2016

Higher versus standard amikacin single dose in emergency department patients with severe sepsis and shock: a randomized controlled trial

scientific article published on 24 November 2017

Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients

scientific article

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

scientific article

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin

scientific article published on 20 June 2016

In vitro disposition profiling of heterocyclic compounds

scientific article published on June 2015

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor

scientific article published on 6 December 2014

Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

scientific article

Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

scientific article published on 22 June 2011

Influence of formulation composition and process on the characteristics and in vitro release from PLGA-based sustained release injectables

scientific article published on 20 November 2014

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

scientific article published on 01 July 1999

Integration and validation of the ex vivo human placenta perfusion model

scientific article published on 15 May 2017

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

scientific article published on 31 March 2017

Intestinal behavior of the ester prodrug tenofovir DF in humans

scientific article published on 4 March 2015

Investigation of Saliva as an Alternative to Plasma Monitoring of Voriconazole.

scientific article published in November 2015

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

scientific article

MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.

scientific article

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function

scientific article published on 08 January 2022

Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat.

scientific article published on 23 December 2015

Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions

scientific article published on 5 September 2015

Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species

scientific article published in 2021

Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport

scientific article

Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs

scientific article

PK/PD of single-dose amikacin in emergency department patients with severe sepsis/shock: should we apply the ICU-based higher loading dose?

scientific article

Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.

scientific article

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

scientific article

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

scientific article

Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

scientific article published on 11 April 2016

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

scientific article published on 7 March 2009

Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

scientific article

Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs

scientific article published on 15 July 2011

Primary Hepatocytes in Sandwich Culture.

scientific article

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

scientific article published on 12 January 2015

Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'.

scientific article published on 6 February 2017

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

scientific article

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

scientific article published on 01 August 2016

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos ⬇️

scientific article published on 06 April 2019

Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.

scientific article

Stability of therapeutic albumin solutions used for molecular adsorbent recirculating system-based liver dialysis.

scientific article published on 28 September 2011

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

scientific article published on 17 June 2016

Supersaturation in human gastric fluids

scientific article published on 11 February 2012

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

scientific article published on 11 August 2016

The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man.

scientific article published on 6 April 2016

The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.

scientific article

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development

scientific article published on 30 December 2020

The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

scientific article published on 07 May 2011

The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.

scientific article published on 8 April 2016

The ontogeny of drug metabolizing enzymes and transporters in the rat

scientific journal article

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates

scientific article published on 7 November 2013

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

scientific article published on 01 April 1997

Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.

scientific article published on 28 December 2015

Unbound Ritonavir Concentrations in Rat and Human Hepatocytes

scientific article published on 18 May 2015

Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling

scientific article published on 11 May 2015

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