List of works - Alex Odermatt

11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story

scientific article

11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice

scientific article

11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ

scientific article published on 04 July 2019

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype

scientific article published in 2022

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish

scientific article published on 7 December 2016

Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors

scientific article published on 21 November 2017

Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio).

scientific article published on 24 January 2014

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity

scientific article published on 26 July 2018

Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated With 46,XY Disorders of Sex Development in Egyptian Patients

scientific article published in September 2017

Biochemical analyses and molecular modeling explain the functional loss of 17β-hydroxysteroid dehydrogenase 3 mutant G133R in three Tunisian patients with 46, XY Disorders of Sex Development

scientific journal article

Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-α.

scientific article published on 27 May 2016

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

scientific article published on 6 September 2017

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis.

scientific article published in February 2018

Cysteine-10 on 17 β -Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals

scientific article

Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion

scientific article published on 20 December 2019

Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1

scientific article published on 12 September 2018

Determination of the topology of endoplasmic reticulum membrane proteins using redox-sensitive green-fluorescence protein fusions

scientific article published on 15 April 2015

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

scientific article published on 09 July 2020

Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools.

scientific article

Drug-induced endocrine blood pressure elevation

scientific article published on 15 June 2019

Effects of lisdexamfetamine on plasma steroid concentrations compared with D-amphetamine in healthy subjects: a randomized, double-blind, placebo-controlled study

scientific article published on 28 October 2018

Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study

scientific article

Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2

scientific article published on 19 March 2019

Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays.

scientific article published on 27 September 2016

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

scientific article published on 26 September 2020

Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism.

scientific article published on 24 December 2013

Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.

scientific article

Gynecomastia and hypertension in a patient treated with posaconazole

scientific article published on 28 September 2020

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes

scientific article

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase

scientific article published on 06 April 2019

Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration

scientific article published on 13 July 2019

Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess

scientific article published in April 2007

In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice

scientific article published on 16 April 2019

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

scientific article

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells

scientific article

Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling

scientific article published on 14 August 2019

Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis

scientific article published in 2021

Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals

scientific article published on 23 January 2020

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.

scientific article published on 4 April 2018

Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV

scientific article

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

scientific article

Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis

scientific article published on 4 May 2017

Posaconazole Serum Drug Levels Associated with Pseudohyperaldosteronism

scientific article published on 12 August 2019

Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2

scientific article published on 06 June 2019

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.

scientific article

Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis

scientific article published on 27 December 2019

Profiling withanolide A for therapeutic targets in neurodegenerative diseases

scientific article published on 13 March 2019

Recycling and screen-segmented column isotachophoresis, two free-fluid approaches for fractionation of proteins ⬇️

scientific article published on 01 June 1991

Removal of batch effects using stratified subsampling of metabolomic data for in vitro endocrine disruptors screening

scientific article published on 08 November 2018

Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases

scientific article published on 07 July 2018

Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use

scientific article published in 2022

The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease

scientific article published on 06 February 2020

The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction

scientific article published on 8 September 2017

Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α

scientific article published on 09 January 2020

List of works by Alex Odermatt

11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story

11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice

11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish

Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors

Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio).

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity

Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated With 46,XY Disorders of Sex Development in Egyptian Patients

Biochemical analyses and molecular modeling explain the functional loss of 17β-hydroxysteroid dehydrogenase 3 mutant G133R in three Tunisian patients with 46, XY Disorders of Sex Development

Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-α.

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis.

Cysteine-10 on 17 β -Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals

Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion

Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1

Determination of the topology of endoplasmic reticulum membrane proteins using redox-sensitive green-fluorescence protein fusions

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools.

Drug-induced endocrine blood pressure elevation

Effects of lisdexamfetamine on plasma steroid concentrations compared with D-amphetamine in healthy subjects: a randomized, double-blind, placebo-controlled study

Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study

Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2

Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays.

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism.

Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.

Gynecomastia and hypertension in a patient treated with posaconazole

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase

Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration

Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess

In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells

Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl- Cotransporter NCC and Transiently Affects Sodium Handling

Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis

Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.

Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis

Posaconazole Serum Drug Levels Associated with Pseudohyperaldosteronism

Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.

Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis

Profiling withanolide A for therapeutic targets in neurodegenerative diseases

Recycling and screen-segmented column isotachophoresis, two free-fluid approaches for fractionation of proteins ⬇️

Removal of batch effects using stratified subsampling of metabolomic data for in vitro endocrine disruptors screening

Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases

Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use

The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease

The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction

Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α