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List of works by Bart Hens

"Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy

scientific article published on 06 June 2019

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

scientific article published on 17 January 2020

A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.

scientific article published on 29 August 2013

Application of a Dynamic Fluid & pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus™

scientific article published on 02 November 2018

Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field-Flow Fractionation/Multiangle Laser Light Scattering.

scientific article

Drug disposition before and after gastric bypass: fenofibrate and posaconazole.

scientific article published on July 2016

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). <i>Pharmaceutics</i>, 202

scientific article published on 25 November 2020

Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.

scientific article published on 25 January 2018

Evaluation of real-life dosing of oral medicines with respect to fluid and food intake in a Dutch-speaking population.

scientific article published on 27 April 2017

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

scientific article published on 15 March 2019

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

scientific article published on 30 November 2016

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

scientific article published on 23 June 2018

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

scientific article published on 29 May 2018

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.

scientific article published on 10 May 2016

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

scientific article

Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools.

scientific article published on 23 July 2014

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation and Precipitation of Posaconazole.

scientific article

In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.

scientific article

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

scientific article published on 20 December 2018

Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen

scientific article published on 17 September 2019

Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State

scientific article published on 12 November 2018

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State

scientific article published on 12 November 2018

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

scientific article published on 24 July 2017

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance

scientific article published on 26 October 2018

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants

scientific article published on 11 November 2020

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model

scientific article published on 29 March 2018

Persistent Threats by Persistent Pollutants: Chemical Nature, Concerns and Future Policy Regarding PCBs-What Are We Heading For?

scientific article

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans.

scientific article published on 22 February 2016

Supersaturation in human gastric fluids

scientific article published on 11 February 2012

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group

scientific article published on 08 April 2019

Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives

scientific article published on 13 May 2020

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