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List of works by Hisakazu Ohtani

5-Fluorouracil treatment alters the expression of intestinal transporters in rats.

scientific article published on 28 August 2017

An increase in serum phenytoin concentration by changes of dosage form: case reports and its mechanism

scientific article published in May 2002

Analysis of the Mechanism of Prolonged Persistence of Drug Interaction between Terbinafine and Amitriptyline or Nortriptyline.

scientific article published in January 2017

Antibronchospasmic, tachycardiac, and hypokalaemic effects of L-isoproterenol in guinea-pigs.

scientific article published in December 1995

Assessment of alpha1-adrenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory.

scientific article published on 17 October 2006

Basal Membrane Localization of MRP1 in Human Placental Trophoblast ⬇️

scientific article published on November 1, 2003

Bitterness of the mixture of clarithromycin dry syrup and carbocisteine preparation--difference between brand name and generic drugs

scientific article

Characteristics of choline transport across the blood-brain barrier in mice: correlation with in vitro data.

scientific article

Characterization of transplacental transfer of paroxetine in perfused human placenta: development of a pharmacokinetic model to evaluate tapered dosing.

scientific article published on 17 September 2013

Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

scientific article

Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy.

scientific article

Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants

scientific article published in 2022

Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.

scientific article published on August 2002

Correction to: Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs

scientific article published on 16 September 2020

Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption

scientific article published on 06 May 2014

Development and Evaluation of the Comment Aid System for Therapeutic Drug Monitoring. I. Application to Valproate ⬇️

scientific article published on 01 December 1991

Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan

scientific article published on 23 March 2017

Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium

scientific article published in June 2007

Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population

scientific article published on 09 April 2013

Effect of bioflavonoids on vincristine transport across blood-brain barrier.

scientific article

Effect of hematocrit on pharmacokinetics of tacrolimus in adult living donor liver transplant recipients.

scientific article published in June 2004

Effect of macrolide antibiotics on uptake of digoxin into rat liver

scientific article published on 01 April 2007

Effects of dosing interval on the pharmacokinetic interaction between oral small spherical activated charcoal and amlodipine in humans.

scientific article published in July 2007

Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

scientific article

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

scientific article

Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B.

scientific article published on 13 January 2006

Effects of hypokalaemia on arrhythmogenic risk of quinidine in rats

scientific article published on 01 January 1998

Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells

scientific article published on 10 May 2007

Functional characterization of adenosine transport across the BBB in mice.

scientific article published on 4 January 2005

Functional characterization of human monocarboxylate transporter 6 (SLC16A5).

scientific article published on 20 September 2005

Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.

scientific article

Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea

scientific article

Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.

scientific article

Improvement of dry mouth by replacing paroxetine with fluvoxamine.

scientific article published on 8 February 2005

In silico evaluation of warfarin-bucolome therapy

scientific article

Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin.

scientific article published on 20 April 2017

Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure

scientific article published on 01 January 2008

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

scientific article published in November 2000

Inhibitory effect of erythromycin on potassium currents in rat ventricular myocytes in comparison with disopyramide.

scientific article published in July 2003

Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

scientific article published on November 2006

Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids.

scientific article

Inhibitory effects of pomelo on the metabolism of tacrolimus and the activities of CYP3A4 and P-glycoprotein.

scientific article published on August 2004

Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes

scientific article published on 01 September 1999

Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.

scientific article published in December 2007

Kinetic analysis of P-glycoprotein-mediated transport by using normal human placental brush-border membrane vesicles.

scientific article published in January 2003

Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.

scientific article published on 20 February 2007

Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists.

scientific article published on August 2006

Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants.

scientific article published on 19 March 2013

Nightmares and panic disorder associated with carvedilol overdose.

scientific article published in November 2002

Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs

scientific article published on 17 June 2020

Pharmacodynamic analysis of the electrocardiographic interaction between disopyramide and erythromycin in rats

scientific article published on 01 February 1999

Pharmacokinetic and pharmacodynamic analysis of the antihypercalcemic effect of incadronate disodium in rats

scientific article published on 01 November 2001

Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine

scientific article published in May 2013

Pharmacokinetic-pharmacodynamic analysis of antipsychotics-induced extrapyramidal symptoms based on receptor occupancy theory incorporating endogenous dopamine release.

scientific article published in June 2005

Physiologically based pharmacokinetic model for pralmorelin hydrochloride in rats

scientific article published on 20 July 2005

Piloerection induced by replacing fluvoxamine with milnacipran

scientific article

Polymorphisms and linkage disequilibrium of the OATP8 (OATP1B3) gene in Japanese subjects.

scientific article

Possibility of the reversal of multidrug resistance and the avoidance of side effects by liposomes modified with MRK-16, a monoclonal antibody to P-glycoprotein.

scientific article

Possible mechanisms for the pharmacokinetic interaction between phenytoin and folinate in rats

scientific article published on 01 August 2007

Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies ⬇️

scientific article published on February 1, 2012

Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice.

scientific article published on 30 August 2014

Prediction of the therapeutic dose for beta-stimulants based on preclinical data: application of oral dosage forms and aerosols to asthmatic patients.

scientific article published on April 1993

Proton gradient-dependent transport of valproic acid in human placental brush-border membrane vesicles.

scientific article published in February 2002

Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

scientific article

Quantitative determination of epinastine in plasma by high-performance liquid chromatography

scientific article published on 01 August 1996

Questionnaire survey of patients comparing the usability of brand-name and generic ketoprofen tapes

scientific article

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

scientific article published in August 2002

Sustained QT prolongation induced by tacrolimus in guinea pigs

scientific article published on 01 January 1999

The canine CYP1A2 deficiency polymorphism dramatically affects the pharmacokinetics of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-D]-pyrimidine-2-(1H)-one (YM-64227), a phosphodiesterase type 4 inhibitor.

scientific article published on 10 February 2006

Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line.

scientific article

Transcellular transport of genistein, a soybean-derived isoflavone, across human colon carcinoma cell line (Caco-2).

scientific article

Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1.

scientific article published on October 2002

Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).

scientific article published on April 2001

Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6.

scientific article published on 25 April 2015

Warfarin and miconazole oral gel interactions: analysis and therapy recommendations based on clinical data and a pharmacokinetic model.

scientific article

[Development and application of an Internet-based educational system to share pharmaceutical case reports between pharmacists]

scientific article published on 01 February 2002

[Development and evaluation of an internet-based educational system about herbs and dietary supplements through periodical distribution of information to health professionals]

scientific article published on 01 June 2009

[Development of the measures to evaluate the similarity of drug brand names]

scientific article published on 01 May 2006

[Model analysis of tulobuterol patch formulations to explain the influence of drug release rate and transdermal transfer rate on the plasma concentration profile]

scientific article published on 01 January 2011

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