List of works - Javier Corral

A KpnI RFLP at the human myeloperoxidase locus.

scientific article

A Radioreceptor Assay for Mass Measurement of Inositol (1,4,5)-Trisphosphate Using Saponin-Permeabilized Outdated Human Platelets

scientific article published in February 1998

A new case of successful outcome of pregnancy in a carrier of homozygous type II (L99F) antithrombin deficiency.

scientific article published in January 2014

A new method to quantify β-antithrombin glycoform in plasma reveals increased levels during the acute stroke event

scientific article published on 06 July 2015

A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis

scientific article

A novel mutation in the antithrombin gene (insT 7429-30) causes superior mesenteric vein thrombosis

scientific article published on 12 July 2006

A novel mutation of antithrombin deficiency in six family siblings and the clinical combat

scientific article published on 16 July 2015

A pharmacogenetic effect of factor XIII valine 34 leucine polymorphism on fibrinolytic therapy for acute myocardial infarction.

scientific article published in January 2005

A simplified assay for the quantification of circulating activated protein C.

scientific article published in June 2016

ALG12-CDG: An unusual patient without intellectual disability and facial dysmorphism, and with a novel variant

scientific article published on 12 June 2020

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

scientific article published on September 1993

Amelioration of the severity of heparin-binding antithrombin mutations by posttranslational mosaicism.

scientific article

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

scientific article

Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis

scientific article published on 23 January 2007

Antithrombin Dublin (p.Val30Glu): a relatively common variant with moderate thrombosis risk of causing transient antithrombin deficiency.

scientific article published on 21 April 2016

Antithrombin Katowice: exon 1 deletion in the SERPINC1 gene associated with type I antithrombin deficiency

scientific article published on 01 January 2015

Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation

scientific article

Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase

scientific article published on 8 June 2016

Antithrombin p.Thr147Ala: The First Founder Mutation in People of African Origin Responsible for Inherited Antithrombin Deficiency

scientific article published on 13 September 2020

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

scientific article published in August 2012

Archeogenetics of F11 p.Cys38Arg: a 5400-year-old mutation identified in different southwestern European countries

scientific article published on 01 May 2019

Assessment of two contact activation reagents for the diagnosis of congenital factor XI deficiency.

scientific article published on 3 January 2018

Association of anthracycline-related cardiac histological lesions with NADPH oxidase functional polymorphisms

scientific article published on 10 April 2013

Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk

scientific article published on 21 March 2013

Beta (β)-antithrombin activity in children and adults: implications for heparin therapy in infants and children

scientific article published on 19 June 2014

Clinical and analytical relevance of the combination of prothrombin 20210A/A and factor V Leiden: results from a large family

scientific article published on 01 May 1999

Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation

Compound heterozygosity involving Antithrombin Cambridge II (p.Ala416Ser) in antithrombin deficiency

scientific article published on 17 January 2013

Congenital disorder of glycosylation (PMM2-CDG) in a patient with antithrombin deficiency and severe thrombophilia.

scientific article

Contribution of Factor VII Genotype to Activated FVII Levels

scientific article published on 01 November 1997

Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a

scientific article published on 16 May 2013

Correction: Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency

scientific article published on 21 July 2016

Correction: Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency.

scientific article

Creating a genotype-based dosing algorithm for acenocoumarol steady dose.

scientific article published on 29 November 2012

Deep venous thrombosis or pulmonary embolism and factor V Leiden: enigma or paradox.

scientific article published on June 2010

Dexamethasone induces a heat-stress response that ameliorates the conformational consequences on antithrombin of L-asparaginase treatment.

scientific article published on 27 April 2009

Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities.

scientific article published on 25 July 2017

Effect of VKORC1, CYP2C9 and CYP4F2 genetic variants in early outcomes during acenocoumarol treatment.

scientific article

Effect of anaesthesia and acute intestinal ischemia on serum beta-N-acetylhexosaminidase activity in rabbit as biological model

scientific article published in June 1992

Effect of citrullination on the function and conformation of antithrombin

scientific article published on 16 October 2009

Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin

scientific article published in September 2009

Endothelial protein C receptor polymorphisms and risk of myocardial infarction

scientific article published on 01 September 2008

Evaluation of Novel Platelet Polymorphisms in Stroke. Dichotomic Effect of rs5443 in GNB3.

scientific article

Evaluation of four rapid methods for hemoglobin screening of whole blood donors in mobile collection settings.

scientific article

Evaluation of leukocyte-depleted platelet concentrates obtained by in-line filtration

scientific article published on 01 January 2000

Evaluation of pooled platelet concentrates using prestorage versus poststorage WBC reduction: impact of filtration timing

scientific article published in July 2000

Evaluation of refrigerated platelet concentrates supplemented with low doses of second messenger effectors.

scientific article

Factor XIII Val34Leu polymorphism modulates the prothrombotic and inflammatory state associated with atrial fibrillation.

scientific article published in September 2004

Factor-V (Arg506 --> Gln) mutation in ischemic cerebrovascular disease.

scientific article published in May 1997

First case with antithrombin deficiency, mesenteric vein thrombosis and pregnancy: Multidisciplinary diagnosis and successful management.

scientific article published on 3 June 2016

Fluctuations in coagulation activity among patients with atrial fibrillation who are stably anticoagulated.

scientific article published on March 2006

Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels

scientific article published on 19 February 2009

GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients

scientific article

Gamma-glutamyl carboxylase R325Q polymorphism on the response of acenocoumarol.

scientific article published on 29 January 2008

Gene rearrangement in acute non-lymphoblastic leukaemia: correlation with morphological and immunophenotypic characteristics of blast cells

scientific article published on 01 January 1995

Genetic Polymorphisms of Platelet Adhesive Molecules: Association with Breast Cancer Risk and Clinical Presentation

scientific article published on 01 July 2003

Genetic characterization of antithrombin, protein C, and protein S deficiencies in Polish patients.

scientific article published on 13 June 2017

Genetic predisposition to fetal alcohol syndrome: association with congenital disorders of N-glycosylation.

scientific article published on 18 August 2017

Genetic variants of the extra-large stimulatory Gs protein alpha-subunit and risk of thrombotic and haemorrhagic disorders.

scientific article

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

scientific journal article

Genotype-guided therapy improves initial acenocoumarol dosing. Results from a prospective randomised study.

scientific article published on 5 November 2015

Genotype-phenotype relationship for six common polymorphisms in genes affecting platelet function from 286 healthy subjects and 160 patients with mucocutaneous bleeding of unknown cause.

scientific article published on 21 April 2009

Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site

scientific article

Heparin affinity of factor VIIa: implications on the physiological inhibition by antithrombin and clearance of recombinant factor VIIa

scientific article published on 3 December 2010

High incidence of FXI deficiency in a Spanish town caused by 11 different mutations and the first duplication of F11: Results from the Yecla study

scientific article published on 27 September 2017

High levels of latent antithrombin in plasma from patients with antithrombin deficiency.

scientific article published on 23 February 2017

Hyperglycaemia impairs antithrombin secretion: possible contribution to the thrombotic risk of diabetes.

scientific article published on 2 July 2009

Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC1 gene defect

scientific article

Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency

scientific article

Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant

scientific article published on 16 June 2016

Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?

scientific article

Identification of coagulation gene 3'UTR variants that are potentially regulated by microRNAs

scientific article published on 26 April 2017

Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome

scientific article

Immunophenotypic, genomic and clinical characteristics of blast crisis of chronic myelogenous leukaemia.

scientific article published in November 1991

In Silico Discovery of a Compound with Nanomolar Affinity to Antithrombin Causing Partial Activation and Increased Heparin Affinity

article by J. Navarro-Fernández et al published 17 July 2012 in Journal of Medicinal Chemistry

In vitro analysis of platelet concentrates stored in the presence of modulators of 3′,5′ adenosine monophosphate, and organic anions

scientific article published in February 2000

In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin.

scientific article published on May 2007

Increased N-glycosylation efficiency by generation of an aromatic sequon on N135 of antithrombin

scientific article

Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody

scientific article published on 13 September 2010

Increased serum N-acetyl-beta-D-glucosaminidase and alpha-D-mannosidase activities in obese subjects

scientific article published in October 1992

Influence of the F12 -4 C>T polymorphism on hemostatic tests

scientific article published on 01 October 2010

Inherited thrombophilic conditions ⬇️

scientific article published on 01 April 2012

Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin.

scientific article published on 14 January 2008

Intracellular retention of hepatic serpins caused by severe hyperlipidemia

scientific article published on 01 August 2006

L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases.

scientific article published on July 2006

Mutations in the shutter region of antithrombin result in formation of disulfide-linked dimers and severe venous thrombosis.

scientific article published in June 2004

New alleles of the platelet glycoprotein Ibalpha gene

scientific article published in December 1998

Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children.

scientific article

Pharmacogenetics of acenocoumarol in patients with extreme dose requirements.

scientific article published on 9 February 2010

Platelet GP IIIa polymorphism HPA-1 (PlA) protects against subarachnoid hemorrhage

scientific article published on 26 August 2004

Platelet cryopreservation using a reduced dimethyl sulfoxide concentration and second-messenger effectors as cryopreserving solution

scientific article published on 01 August 1999

Platelet septin complexes form rings and associate with the microtubular network.

scientific article

Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.

scientific article

Polymorphisms of platelet adhesive receptors: do they play a role in primary intracerebral hemorrhage?

scientific article published on 01 January 2003

Potential role of miRNAs in developmental haemostasis

scientific article

Prognostic value of annexin A5 -1 C/T polymorphism in a long term follow-up after premature myocardial infarction

scientific article published on 01 April 2007

Protective role of antithrombin in mouse models of liver injury

scientific article published on 26 June 2012

Protein Z-dependent protease inhibitor W303X mutation in venous thrombosis.

scientific article

Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis.

scientific article published on April 2007

Proteomic analysis of platelet N-glycoproteins in PMM2-CDG patients.

scientific article published on 21 December 2013

Prothrombin A19911G and G20210A polymorphisms' role in thrombosis

scientific article published on 01 August 2002

Puzzling questions on antithrombin: Diagnostic limitations and real incidence in venous and arterial thrombosis

scientific article published on 14 April 2015

Quality assessment of platelet concentrates supplemented with second-messenger effectors

scientific article published in February 1999

Rare homozygous status of P43 β1-tubulin polymorphism causes alterations in platelet ultrastructure.

scientific article published on 8 March 2011

Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency

scientific article published on 28 September 2017

Regulatory regions of SERPINC1 gene: Identification of the first mutation associated with antithrombin deficiency

article

Role of factor XIII Val34Leu polymorphism in patients <45 years of age with acute myocardial infarction.

scientific article

Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models.

scientific article published on April 2005

Role of the C-sheet in the maturation of N-glycans on antithrombin: functional relevance of pleiotropic mutations.

scientific article

Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders

scientific article published on 09 June 2010

Synergism between factor XII -4C>T and factor XIII Val34Leu polymorphisms in fibrinolytic therapy in acute myocardial infarction

scientific article published on 29 June 2010

Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction

scientific article published on 01 December 2005

The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol.

scientific article published on 21 May 2007

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

scientific article

The number of platelet glycoprotein Ia molecules is associated with the genetically linked 807 C/T and HPA-5 polymorphisms

scientific article published on 01 April 1999

Thyroglobulin gene point mutation associated with non-endemic simple goitre.

scientific article

Transient desialylation in combination with a novel antithrombin deficiency causing a severe and recurrent thrombosis despite anticoagulation therapy

scientific article published on 17 March 2017

Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance

scientific article

Uniparental disomy causes deficiencies of vitamin K-dependent proteins

scientific article published on 28 September 2016

What can Drosophila tell us about serpins, thrombosis and dementia?

scientific article published on January 2004

[Hereditary thrombophilia: learnt lessons and pending duties]

scientific article published on 01 May 2007

miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle

scientific article published on January 2012

List of works by Javier Corral

A KpnI RFLP at the human myeloperoxidase locus.

A Radioreceptor Assay for Mass Measurement of Inositol (1,4,5)-Trisphosphate Using Saponin-Permeabilized Outdated Human Platelets

A new case of successful outcome of pregnancy in a carrier of homozygous type II (L99F) antithrombin deficiency.

A new method to quantify β-antithrombin glycoform in plasma reveals increased levels during the acute stroke event

A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis

A novel mutation in the antithrombin gene (insT 7429-30) causes superior mesenteric vein thrombosis

A novel mutation of antithrombin deficiency in six family siblings and the clinical combat

A pharmacogenetic effect of factor XIII valine 34 leucine polymorphism on fibrinolytic therapy for acute myocardial infarction.

A simplified assay for the quantification of circulating activated protein C.

ALG12-CDG: An unusual patient without intellectual disability and facial dysmorphism, and with a novel variant

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

Amelioration of the severity of heparin-binding antithrombin mutations by posttranslational mosaicism.

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis

Antithrombin Dublin (p.Val30Glu): a relatively common variant with moderate thrombosis risk of causing transient antithrombin deficiency.

Antithrombin Katowice: exon 1 deletion in the SERPINC1 gene associated with type I antithrombin deficiency

Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation

Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase

Antithrombin p.Thr147Ala: The First Founder Mutation in People of African Origin Responsible for Inherited Antithrombin Deficiency

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Archeogenetics of F11 p.Cys38Arg: a 5400-year-old mutation identified in different southwestern European countries

Assessment of two contact activation reagents for the diagnosis of congenital factor XI deficiency.

Association of anthracycline-related cardiac histological lesions with NADPH oxidase functional polymorphisms

Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk

Beta (β)-antithrombin activity in children and adults: implications for heparin therapy in infants and children

Clinical and analytical relevance of the combination of prothrombin 20210A/A and factor V Leiden: results from a large family

Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation

Compound heterozygosity involving Antithrombin Cambridge II (p.Ala416Ser) in antithrombin deficiency

Congenital disorder of glycosylation (PMM2-CDG) in a patient with antithrombin deficiency and severe thrombophilia.

Contribution of Factor VII Genotype to Activated FVII Levels

Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a

Correction: Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency

Correction: Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency.

Creating a genotype-based dosing algorithm for acenocoumarol steady dose.

Deep venous thrombosis or pulmonary embolism and factor V Leiden: enigma or paradox.

Dexamethasone induces a heat-stress response that ameliorates the conformational consequences on antithrombin of L-asparaginase treatment.

Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities.

Effect of VKORC1, CYP2C9 and CYP4F2 genetic variants in early outcomes during acenocoumarol treatment.

Effect of anaesthesia and acute intestinal ischemia on serum beta-N-acetylhexosaminidase activity in rabbit as biological model

Effect of citrullination on the function and conformation of antithrombin

Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin

Endothelial protein C receptor polymorphisms and risk of myocardial infarction

Evaluation of Novel Platelet Polymorphisms in Stroke. Dichotomic Effect of rs5443 in GNB3.

Evaluation of four rapid methods for hemoglobin screening of whole blood donors in mobile collection settings.

Evaluation of leukocyte-depleted platelet concentrates obtained by in-line filtration

Evaluation of pooled platelet concentrates using prestorage versus poststorage WBC reduction: impact of filtration timing

Evaluation of refrigerated platelet concentrates supplemented with low doses of second messenger effectors.

Factor XIII Val34Leu polymorphism modulates the prothrombotic and inflammatory state associated with atrial fibrillation.

Factor-V (Arg506 --> Gln) mutation in ischemic cerebrovascular disease.

First case with antithrombin deficiency, mesenteric vein thrombosis and pregnancy: Multidisciplinary diagnosis and successful management.

Fluctuations in coagulation activity among patients with atrial fibrillation who are stably anticoagulated.

Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels

GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients

Gamma-glutamyl carboxylase R325Q polymorphism on the response of acenocoumarol.

Gene rearrangement in acute non-lymphoblastic leukaemia: correlation with morphological and immunophenotypic characteristics of blast cells

Genetic Polymorphisms of Platelet Adhesive Molecules: Association with Breast Cancer Risk and Clinical Presentation

Genetic characterization of antithrombin, protein C, and protein S deficiencies in Polish patients.

Genetic predisposition to fetal alcohol syndrome: association with congenital disorders of N-glycosylation.

Genetic variants of the extra-large stimulatory Gs protein alpha-subunit and risk of thrombotic and haemorrhagic disorders.

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Genotype-guided therapy improves initial acenocoumarol dosing. Results from a prospective randomised study.

Genotype-phenotype relationship for six common polymorphisms in genes affecting platelet function from 286 healthy subjects and 160 patients with mucocutaneous bleeding of unknown cause.

Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site

Heparin affinity of factor VIIa: implications on the physiological inhibition by antithrombin and clearance of recombinant factor VIIa

High incidence of FXI deficiency in a Spanish town caused by 11 different mutations and the first duplication of F11: Results from the Yecla study

High levels of latent antithrombin in plasma from patients with antithrombin deficiency.

Hyperglycaemia impairs antithrombin secretion: possible contribution to the thrombotic risk of diabetes.

Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC1 gene defect

Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency

Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant

Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?

Identification of coagulation gene 3'UTR variants that are potentially regulated by microRNAs

Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome

Immunophenotypic, genomic and clinical characteristics of blast crisis of chronic myelogenous leukaemia.

In Silico Discovery of a Compound with Nanomolar Affinity to Antithrombin Causing Partial Activation and Increased Heparin Affinity

In vitro analysis of platelet concentrates stored in the presence of modulators of 3′,5′ adenosine monophosphate, and organic anions

In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin.

Increased N-glycosylation efficiency by generation of an aromatic sequon on N135 of antithrombin

Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody