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List of works by Aki Hirayama

A case of glomerulonephritis with singular high titer of anticardiolipin antibody

scientific article

A novel nonenzymatic pathway for the generation of nitric oxide by the reaction of hydrogen peroxide and D- or L-arginine

scientific article published on 01 April 1997

Antioxidant capacity in rat skeletal muscle tissues determined by electron spin resonance

scientific article published on 01 February 2003

Association of ecNOS gene polymorphisms with end stage renal diseases.

scientific article

Biosynthesis of methylguanidine in the hepatic peroxisomes and the effect of the induction of peroxisomal enzymes by clofibrate

scientific article published on 01 January 1998

Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation.

scientific article published on 5 September 2012

Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell

scientific article

Clinical significance of redox effects of Kampo formulae, a traditional Japanese herbal medicine: comprehensive estimation of multiple antioxidative activities.

scientific article published on 12 December 2017

Combination Therapy with Peritoneal Dialysis and Hemodialysis from the Initiation of Renal Replacement Therapy Preserves Residual Renal Function and Serum Albumin

scientific article published in January 2017

Decreased serum antioxidant activity of hemodialysis patients demonstrated by methylguanidine synthesis and microsomal lipid peroxidation

scientific article published on 01 January 1996

Design and use of silica-containing redox nanoparticles, siRNPs, for high-performance peritoneal dialysis.

scientific article published in March 2014

Dose-dependent decrease in anti-oxidant capacity of whole blood after irradiation: A novel potential marker for biodosimetry.

scientific article published on 9 May 2018

Effect of CV159-Ca(2+)/calmodulin blockade on redox status hepatic ischemia-reperfusion injury in mice evaluated by a newly developed in vivo EPR imaging technique.

scientific article published on 31 July 2007

Effect of Keishibukuryogan, a Japanese Traditional Kampo Prescription, on Improvement of Microcirculation and Oketsu and Induction of Endothelial Nitric Oxide: A Live Imaging Study.

scientific article published on 13 July 2017

Effect of spontaneous exercise on antioxidant capacity in rat muscles determined by electron spin resonance

scientific article published on 01 February 2006

Electron paramagnetic resonance imaging of nitric oxide organ distribution in lipopolysuccaride treated mice.

scientific article published in February 2003

Electron paramagnetic resonance imaging of oxidative stress in renal disease

scientific article published on 10 March 2006

Elimination of lipid peroxide during hemodialysis

scientific article published on 26 June 2007

Evaluation of adriamycin nephropathy by an in vivo electron paramagnetic resonance.

scientific article published in July 2005

Favorable effect of hemodialysis on decreased serum antioxidant activity in hemodialysis patients demonstrated by electron spin resonance

scientific article published on 01 July 1997

Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals

scientific article published on 01 July 1999

Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells ⬇️

scientific article published on July 26, 2011

Hemodialysis does not influence the peroxidative state already present in uremia

scientific article published on 01 December 2000

Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.

scientific article published on December 2008

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.

scientific article

Identification by an EPR technique of decreased mitochondrial reducing activity in puromycin aminonucleoside-induced nephrosis.

scientific article published in October 2002

Importance of renal mitochondria in the reduction of TEMPOL, a nitroxide radical.

scientific article published in February 2003

In vivo detection of intrinsic reactive oxygen species using acyl-protected hydroxylamine in puromycin nephrosis

scientific article published in July 2007

In vivo imaging of renal redox status during azelnidipine treatment.

scientific article published in August 2008

In vivo temporal EPR imaging for estimating the kinetics of a nitroxide radical in the renal parenchyma and pelvis in rats

scientific article published on 01 January 2002

Increased lipid peroxidation by rat liver microsomes in experimental renal failure

scientific article published on 01 January 1996

Inhibition by heparin of protein kinase C activation and hydroxyl radical generation in puromycin aminonucleoside treated isolated rat hepatocytes

scientific article published in February 2003

Kangen-karyu raises surface body temperature through oxidative stress modification

scientific article published on 2 April 2016

L-arginine administration reverses anemia associated with renal disease

scientific article published on 01 August 2007

Light-shielded hemodialysis prevents hypotension and lipid peroxidation by inhibiting nitric oxide production

scientific article published on 01 December 2005

Live-Imaging Analysis of Target Vessels and Nitric Oxide Production Associated with Gosha-Jinki-Gan and Keishi-Bukuryo-Gan: Two Herbal Preparations with Clinically Proven Blood Flow-Improving Effects but with Different Traditional Clinical Indicativ

scientific article published in 2022

Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets

scientific article

NO is not exclusively generated by the reaction of L-arginine and NOS and is poorly identified by the Griess reaction or Clark-type electrodes

scientific article published on 01 January 1997

Neurovascular Unit Protection From Cerebral Ischemia-Reperfusion Injury by Radical-Containing Nanoparticles in Mice.

scientific article published on 27 June 2017

Newly synthesized radical-containing nanoparticles enhance neuroprotection after cerebral ischemia-reperfusion injury

scientific article published on 01 May 2011

Nitric oxide protection against adriamycin-induced tubulointerstitial injury.

scientific article

Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr.

scientific article published in May 2004

PPAR-γ activator pioglitazone prevents age-related atrial fibrillation susceptibility by improving antioxidant capacity and reducing apoptosis in a rat model

scientific article published on 28 September 2011

Peritoneal Dialysis Preserves Residual Renal Function and Reduces Oxidative Stress During the Initial Period of Dialysis Therapy

scientific article published in January 2017

Prevention of delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage

scientific article published on 01 August 2001

Proanthocyanidin promotes free radical-scavenging activity in muscle tissues and plasma

scientific article published in December 2007

Reactive oxygen species induced by non-steroidal anti-inflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells

scientific article published on 19 February 2016

Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells.

scientific article

Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.

scientific article

Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation.

scientific article published on 21 October 2013

Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor.

scientific article

Role of reactive oxygen and argininosuccinate in guanidinosuccinate synthesis in isolated rat hepatocytes

scientific article published on 01 January 1996

S-nitrosothiols are stored by platelets and released during platelet-neutrophil interactions

scientific article published on 01 January 1999

Spherical carbon adsorbent (AST-120) protects deterioration of renal function in chronic kidney disease rats through inhibition of reactive oxygen species production from mitochondria and reduction of serum lipid peroxidation

scientific article published on 28 April 2010

The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles.

scientific article

The antioxidant EPC-K1 ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischaemia.

scientific article published in June 2003

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis.

scientific article

Thiobarbituric acid reactive substances are increased in the subcutaneous fat tissue of patients with end-stage renal disease

scientific article published on 01 April 1997

pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances.

scientific article published in September 2009

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